ENSDARG00000103108


Danio rerio

Features
Gene ID: ENSDARG00000103108
  
Biological name :acvr2bb
  
Synonyms : activin A receptor type 2Bb / acvr2bb
  
Possible biological names infered from orthology : activin A receptor type 2B / Activin receptor type-2B / ACVR2B / P27040 / Q13705
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 51818039
Gene end: 51854668
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000133826
NCBI entrez gene - 100331938     See in Manteia.
swissprot - A0A0G2KN81
ZFIN ID - ZDB-GENE-170621-5
Ensembl - ENSDARG00000103108
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ACVR2BENSGALG00000006158Gallus gallus
 ACVR2BENSG00000114739Homo sapiens
 Acvr2bENSMUSG00000061393Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
acvr2ba / activin A receptor type 2Ba / Q13705* / ACVR2B* / P27040* / Activin receptor type-2B * / activin A receptor type 2B*ENSDARG0000004442271
acvr2aa / activin A receptor type 2Aa / P27038* / ACVR2A* / P27037* / Activin receptor type-2A * / activin A receptor type 2A*ENSDARG0000001118863
acvr2ab / activin A receptor type 2Ab / ACVR2A* / P27037* / activin A receptor type 2A*ENSDARG0000010470056
bmpr2b / bone morphogenetic protein receptor, type II b (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*ENSDARG0000002005736
bmpr2a / bone morphogenetic protein receptor, type II a (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*ENSDARG0000001194133
tgfbr2b / transforming growth factor beta receptor 2b / Q62312* / TGFBR2* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*ENSDARG0000003454133
tgfbr2a / transforming growth factor beta receptor 2a / P37173* / TGFBR2* / transforming growth factor beta receptor 2*ENSDARG0000005936332
si:dkey-101k6.5ENSDARG0000005513632
acvr1l / activin A receptor, type 1 like / ACVR1* / Q04771* / P37172* / activin A receptor type 1* / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA.*ENSDARG0000001498630
tgfbr1a / transforming growth factor, beta receptor 1 a / Q64729* / TGFBR1* / P36897* / transforming growth factor beta receptor 1* / transforming growth factor, beta receptor I*ENSDARG0000001749430
acvr1bb / activin A receptor type 1Bb / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*ENSDARG0000005214230
acvr1ba / activin A receptor type 1Ba / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*ENSDARG0000001896829
ACVR1C / activin A receptor type 1C / Q8NER5*ENSDARG0000008617229
tgfbr1b / transforming growth factor, beta receptor 1 b / P36897* / TGFBR1* / transforming growth factor beta receptor 1*ENSDARG0000004225929
bmpr1bb / bone morphogenetic protein receptor, type IBb / BMPR1B* / O00238* / bone morphogenetic protein receptor type 1B*ENSDARG0000010274228
bmpr1ab / bone morphogenetic protein receptor, type IAb / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSDARG0000010504528
bmpr1ba / bone morphogenetic protein receptor, type IBa / P36898* / O00238* / BMPR1B* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B ...ENSDARG0000010410028
acvrl1 / activin A receptor like type 1 / P37023* / Q61288* / Serine/threonine-protein kinase receptor R3 *ENSDARG0000001817928
bmpr1aa / bone morphogenetic protein receptor, type IAa / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSDARG0000001972827


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000472  Activin types I and II receptor domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Signaling by Activin
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011188 acvr2aa / activin A receptor type 2Aa / P27038* / ACVR2A* / P27037* / Activin receptor type-2A * / activin A receptor type 2A*  / reaction / complex
 ENSDARG00000012671 inhbaa / inhibin, beta Aa / INHBA* / P08476* / inhibin beta A subunit*  / complex / reaction
 ENSDARG00000016086 smurf1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *  / complex / reaction
 ENSDARG00000018968 acvr1ba / activin A receptor type 1Ba / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*  / reaction / complex
 ENSDARG00000044422 acvr2ba / activin A receptor type 2Ba / Q13705* / ACVR2B* / P27040* / Activin receptor type-2B * / activin A receptor type 2B*  / reaction / complex
 ENSDARG00000027199 smad1 / SMAD family member 1 / SMAD5* / Q99717* / P70340* / P97454* / Q15797* / SMAD family member 5* / Mothers against decapentaplegic homolog 5 *  / reaction / complex
 ENSDARG00000019728 bmpr1aa / bone morphogenetic protein receptor, type IAa / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / complex / reaction
 ENSDARG00000021938 alg5 / smad9 / SMAD family member 9 / O15198* / Q9JIW5* / Mothers against decapentaplegic homolog 9 *  / reaction / complex
 ENSDARG00000037238 smad5 / Q9W7E7 / SMAD family member 5 / SMAD1* / Q99717* / P97454* / Q15797* / P70340* / SMAD family member 1* / Mothers against decapentaplegic homolog 5 *  / complex / reaction
 ENSDARG00000052142 acvr1bb / activin A receptor type 1Bb / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*  / complex / reaction
 ENSDARG00000011941 bmpr2a / bone morphogenetic protein receptor, type II a (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*  / complex
 ENSDARG00000040777 inhbb / inhibin, beta B / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*  / complex / reaction
 ENSDARG00000038067 A9JRZ0 / smurf2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *  / complex / reaction
 ENSDARG00000031763 smad6b / SMAD family member 6b / SMAD6* / O43541* / O35182* / SMAD family member 6* / Mothers against decapentaplegic homolog 6 *  / complex / reaction
 ENSDARG00000041430 bmp2b / bone morphogenetic protein 2b / BMP2* / P21274* / P12643* / Bone morphotic protein 2 * / bone morphogenetic protein 2*  / reaction / complex
 ENSDARG00000020057 bmpr2b / bone morphogenetic protein receptor, type II b (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*  / complex
 ENSDARG00000086172 ACVR1C / activin A receptor type 1C / Q8NER5*  / complex
 ENSDARG00000103892 CABZ01074203.1 / INHBB* / P09529* / inhibin beta B subunit*  / complex / reaction
 ENSDARG00000104700 acvr2ab / activin A receptor type 2Ab / ACVR2A* / P27037* / activin A receptor type 2A*  / reaction / complex
 ENSDARG00000105045 bmpr1ab / bone morphogenetic protein receptor, type IAb / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / complex / reaction
 ENSDARG00000103108 acvr2bb / activin A receptor type 2Bb / ACVR2B* / Q13705* / activin A receptor type 2B*  / reaction / complex
 ENSDARG00000075747 zfyve16 / zinc finger, FYVE domain containing 16 / Q7Z3T8* / Q80U44* / zinc finger FYVE-type containing 16*  / complex / reaction






 

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