ENSDARG00000014986


Danio rerio

Features
Gene ID: ENSDARG00000014986
  
Biological name :acvr1l
  
Synonyms : activin A receptor, type 1 like / acvr1l
  
Possible biological names infered from orthology : activin A receptor type 1 / ACVR1 / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA. / P37172 / Q04771
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 41524238
Gene end: 41543762
  
Corresponding Affymetrix probe sets: Dr.606.1.S2_at (Zebrafish Array)   NM_131345_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000111550
Ensembl peptide - ENSDARP00000003221
Ensembl peptide - ENSDARP00000108954
NCBI entrez gene - 30615     See in Manteia.
RefSeq - NM_131345
RefSeq - XM_021478751
RefSeq Peptide - NP_571420
swissprot - O73736
swissprot - E9QIU0
ZFIN ID - ZDB-GENE-990415-9
Ensembl - ENSDARG00000014986
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ACVR1ENSGALG00000037301Gallus gallus
 ACVR1ENSG00000115170Homo sapiens
 Acvr1ENSMUSG00000026836Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
acvrl1 / activin A receptor like type 1 / P37023* / Q61288* / Serine/threonine-protein kinase receptor R3 *ENSDARG0000001817954
acvr1bb / activin A receptor type 1Bb / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*ENSDARG0000005214246
acvr1ba / activin A receptor type 1Ba / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*ENSDARG0000001896846
bmpr1bb / bone morphogenetic protein receptor, type IBb / BMPR1B* / O00238* / bone morphogenetic protein receptor type 1B*ENSDARG0000010274246
tgfbr1a / transforming growth factor, beta receptor 1 a / Q64729* / TGFBR1* / P36897* / transforming growth factor beta receptor 1* / transforming growth factor, beta receptor I*ENSDARG0000001749445
tgfbr1b / transforming growth factor, beta receptor 1 b / P36897* / TGFBR1* / transforming growth factor beta receptor 1*ENSDARG0000004225945
bmpr1ba / bone morphogenetic protein receptor, type IBa / P36898* / O00238* / BMPR1B* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B ...ENSDARG0000010410045
bmpr1aa / bone morphogenetic protein receptor, type IAa / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSDARG0000001972844
ACVR1C / activin A receptor type 1C / Q8NER5*ENSDARG0000008617243
bmpr1ab / bone morphogenetic protein receptor, type IAb / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSDARG0000010504543
acvr2bb / activin A receptor type 2Bb / ACVR2B* / Q13705* / activin A receptor type 2B*ENSDARG0000010310830
acvr2aa / activin A receptor type 2Aa / P27038* / ACVR2A* / P27037* / Activin receptor type-2A * / activin A receptor type 2A*ENSDARG0000001118829
tgfbr2b / transforming growth factor beta receptor 2b / Q62312* / TGFBR2* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*ENSDARG0000003454128
si:dkey-101k6.5ENSDARG0000005513628
acvr2ba / activin A receptor type 2Ba / Q13705* / ACVR2B* / P27040* / Activin receptor type-2B * / activin A receptor type 2B*ENSDARG0000004442227
acvr2ab / activin A receptor type 2Ab / ACVR2A* / P27037* / activin A receptor type 2A*ENSDARG0000010470027
bmpr2a / bone morphogenetic protein receptor, type II a (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*ENSDARG0000001194126
bmpr2b / bone morphogenetic protein receptor, type II b (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*ENSDARG0000002005726
tgfbr2a / transforming growth factor beta receptor 2a / P37173* / TGFBR2* / transforming growth factor beta receptor 2*ENSDARG0000005936326


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003605  GS domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003140 determination of left/right asymmetry in lateral mesoderm IMP
 biological_processGO:0003143 embryonic heart tube morphogenesis IMP
 biological_processGO:0003146 heart jogging IMP
 biological_processGO:0003230 cardiac atrium development IMP
 biological_processGO:0003342 proepicardium development IMP
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0021556 central nervous system formation IMP
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030509 BMP signaling pathway IGI
 biological_processGO:0030510 regulation of BMP signaling pathway IMP
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035124 embryonic caudal fin morphogenesis IMP
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0035462 determination of left/right asymmetry in diencephalon IMP
 biological_processGO:0042476 odontogenesis IMP
 biological_processGO:0046588 negative regulation of calcium-dependent cell-cell adhesion IMP
 biological_processGO:0048264 determination of ventral identity IMP
 biological_processGO:0048332 mesoderm morphogenesis IMP
 biological_processGO:0048368 lateral mesoderm development IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0060030 dorsal convergence IMP
 biological_processGO:0061371 determination of heart left/right asymmetry IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070724 BMP receptor complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle dislocated yolk , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle deformed , abnormal
Show

 ZFA:0000040 median fin fold median fin fold hypoplastic , abnormal
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 ZFA:0000077 tail bud tail bud everted , abnormal
tail bud increased size , abnormal
Show

 ZFA:0000101 diencephalon diencephalon bilateral , abnormal
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 ZFA:0000108 fin fin decreased size , abnormal
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 ZFA:0000114 heart heart morphology , abnormal
heart edematous , abnormal
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 ZFA:0000115 heart rudiment heart rudiment rotated , abnormal
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 ZFA:0000123 liver liver aplastic , abnormal
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 ZFA:0000140 pancreas pancreas aplastic , abnormal
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 ZFA:0000180 caudal vein caudal vein absent , abnormal
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 ZFA:0000292 surface structure surface structure quality , abnormal
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 ZFA:0000471 atrium atrium position , abnormal
atrium increased width , abnormal
atrium cardiac muscle cell decreased amount , abnormal
atrium deformed , abnormal
Show

 ZFA:0001058 caudal fin caudal fin ventral side aplastic , abnormal
caudal fin ventral region hypoplastic , abnormal
Show

 ZFA:0001069 ventral fin fold ventral fin fold morphology , abnormal
ventral fin fold absent , abnormal
ventral fin fold aplastic , abnormal
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 ZFA:0001094 whole organism whole organism wholly dorsalized , abnormal
whole organism lethal (sensu genetics) , abnormal
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 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region truncated , abnormal
post-vent region somite increased width , abnormal
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 ZFA:0001161 pectoral fin pectoral fin quality , abnormal
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 ZFA:0001162 anal fin anal fin absent , abnormal
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 ZFA:0001261 ventricular system ventricular system aplastic , abnormal
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 ZFA:0001286 caudal vein plexus caudal vein plexus absent , abnormal
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 ZFA:0001605 caudal fin lower lobe caudal fin lower lobe mislocalised , abnormal
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 ZFA:0001655 pericardial cavity pericardial cavity increased size , abnormal
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 ZFA:0005041 anterior lateral plate mesoderm anterior lateral plate mesoderm decreased width , abnormal
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 ZFA:0005057 epicardium epicardium aplastic , abnormal
Show

 ZFA:0009102 pancreatic B cell pancreatic B cell decreased amount , abnormal
Show

 ZFA:0009325 erythroid lineage cell erythroid lineage cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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