Manteia

ENSDARG00000042259

Danio rerio

Features

Gene ID:	ENSDARG00000042259

Biological name :	tgfbr1b

Synonyms :	tgfbr1b / transforming growth factor, beta receptor 1 b

Possible biological names infered from orthology :	P36897 / Q64729 / TGFBR1 / transforming growth factor beta receptor 1 / transforming growth factor, beta receptor I

Species:	Danio rerio

Chr. number:	24
Strand:	1
Band:
Gene start:	119680
Gene end:	150447

Corresponding Affymetrix probe sets:

Cross references:	Ensembl peptide - ENSDARP00000061972 NCBI entrez gene - 792928 See in Manteia. RefSeq - NM_001115059 RefSeq Peptide - NP_001108531 swissprot - F1QQ20 ZFIN ID - ZDB-GENE-091027-1 Ensembl - ENSDARG00000042259

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
TGFBR1	ENSGALG00000033179	Gallus gallus
P36897	ENSG00000106799	Homo sapiens
Q64729	ENSMUSG00000007613	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
tgfbr1a / transforming growth factor, beta receptor 1 a / Q64729* / TGFBR1* / P36897* / transforming growth factor beta receptor 1* / transforming growth factor, beta receptor I*	ENSDARG00000017494	78
acvr1ba / activin A receptor type 1Ba / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*	ENSDARG00000018968	66
acvr1bb / activin A receptor type 1Bb / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*	ENSDARG00000052142	64
ACVR1C / activin A receptor type 1C / Q8NER5*	ENSDARG00000086172	61
bmpr1aa / bone morphogenetic protein receptor, type IAa / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*	ENSDARG00000019728	49
bmpr1ba / bone morphogenetic protein receptor, type IBa / P36898* / O00238* / BMPR1B* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B ...	ENSDARG00000104100	49
bmpr1bb / bone morphogenetic protein receptor, type IBb / BMPR1B* / O00238* / bone morphogenetic protein receptor type 1B*	ENSDARG00000102742	49
bmpr1ab / bone morphogenetic protein receptor, type IAb / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*	ENSDARG00000105045	48
acvrl1 / activin A receptor like type 1 / P37023* / Q61288* / Serine/threonine-protein kinase receptor R3 *	ENSDARG00000018179	46
acvr1l / activin A receptor, type 1 like / ACVR1* / Q04771* / P37172* / activin A receptor type 1* / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA.*	ENSDARG00000014986	46
tgfbr2b / transforming growth factor beta receptor 2b / Q62312* / TGFBR2* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*	ENSDARG00000034541	30
tgfbr2a / transforming growth factor beta receptor 2a / P37173* / TGFBR2* / transforming growth factor beta receptor 2*	ENSDARG00000059363	30
acvr2bb / activin A receptor type 2Bb / ACVR2B* / Q13705* / activin A receptor type 2B*	ENSDARG00000103108	30
si:dkey-101k6.5	ENSDARG00000055136	28
acvr2aa / activin A receptor type 2Aa / P27038* / ACVR2A* / P27037* / Activin receptor type-2A * / activin A receptor type 2A*	ENSDARG00000011188	28
acvr2ba / activin A receptor type 2Ba / Q13705* / ACVR2B* / P27040* / Activin receptor type-2B * / activin A receptor type 2B*	ENSDARG00000044422	27
bmpr2b / bone morphogenetic protein receptor, type II b (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*	ENSDARG00000020057	26
bmpr2a / bone morphogenetic protein receptor, type II a (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*	ENSDARG00000011941	26
acvr2ab / activin A receptor type 2Ab / ACVR2A* / P27037* / activin A receptor type 2A*	ENSDARG00000104700	26

Protein motifs (from Interpro)

Interpro ID	Name
IPR000333	Ser/Thr protein kinase, TGFB receptor
IPR000472	Activin types I and II receptor domain
IPR000719	Protein kinase domain
IPR003605	GS domain
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR017441	Protein kinase, ATP binding site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	IEA
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0023014	signal transduction by protein phosphorylation	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004674	protein serine/threonine kinase activity	IEA
molecular_function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA
molecular_function	GO:0004702	obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity	IEA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Downregulation of TGF-beta receptor signaling

TGF-beta receptor signaling activates SMADs

TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

Ub-specific processing proteases

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000016086	smurf1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *	/ complex / reaction
ENSDARG00000036096	smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *	/ reaction
ENSDARG00000006389	smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *	/ reaction
ENSDARG00000059363	tgfbr2a / transforming growth factor beta receptor 2a / P37173* / TGFBR2* / transforming growth factor beta receptor 2*	/ complex
ENSDARG00000034541	tgfbr2b / transforming growth factor beta receptor 2b / Q62312* / TGFBR2* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*	/ complex
ENSDARG00000038067	A9JRZ0 / smurf2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *	/ complex
ENSDARG00000042259	tgfbr1b / transforming growth factor, beta receptor 1 b / P36897* / TGFBR1* / transforming growth factor beta receptor 1*	/ complex
ENSDARG00000034895	tgfb1b / transforming growth factor, beta 1b / TGFB1* / P04202* / P01137* / transforming growth factor beta 1*	/ complex
ENSDARG00000017494	tgfbr1a / transforming growth factor, beta receptor 1 a / Q64729* / TGFBR1* / P36897* / transforming growth factor beta receptor 1* / transforming growth factor, beta receptor I*	/ complex
ENSDARG00000101903	zfyve9a / zinc finger, FYVE domain containing 9a / ZFYVE9* / O95405* / zinc finger FYVE-type containing 9* / zinc finger, FYVE domain containing 9*	/ complex / reaction
ENSDARG00000055381	bambia / BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a / BAMBI* / Q13145* / Q9D0L6* / BMP and activin membrane bound inhibitor* / BMP and activin membrane-bound inhibi...	/ complex / reaction
ENSDARG00000007405	strap / serine/threonine kinase receptor associated protein / Q9Y3F4* / Q9Z1Z2*	/ complex
ENSDARG00000099677	bambib / BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b / BAMBI* / Q13145* / BMP and activin membrane bound inhibitor*	/ complex / reaction

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr