ENSDARG00000018968


Danio rerio

Features
Gene ID: ENSDARG00000018968
  
Biological name :acvr1ba
  
Synonyms : activin A receptor type 1Ba / acvr1ba
  
Possible biological names infered from orthology : activin A receptor type 1B / Activin receptor type-1B / ACVR1B / P36896 / Q61271
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 27800519
Gene end: 27822920
  
Corresponding Affymetrix probe sets: Dr.3589.1.A1_at (Zebrafish Array)   Dr.5760.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000004431
swissprot - B3DJ37
ZFIN ID - ZDB-GENE-980526-527
Ensembl - ENSDARG00000018968
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ACVR1BENSGALG00000029599Gallus gallus
 ACVR1BENSG00000135503Homo sapiens
 Acvr1bENSMUSG00000000532Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
acvr1bb / activin A receptor type 1Bb / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*ENSDARG0000005214284
tgfbr1b / transforming growth factor, beta receptor 1 b / P36897* / TGFBR1* / transforming growth factor beta receptor 1*ENSDARG0000004225966
tgfbr1a / transforming growth factor, beta receptor 1 a / Q64729* / TGFBR1* / P36897* / transforming growth factor beta receptor 1* / transforming growth factor, beta receptor I*ENSDARG0000001749465
ACVR1C / activin A receptor type 1C / Q8NER5*ENSDARG0000008617261
bmpr1ba / bone morphogenetic protein receptor, type IBa / P36898* / O00238* / BMPR1B* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B ...ENSDARG0000010410048
bmpr1aa / bone morphogenetic protein receptor, type IAa / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSDARG0000001972848
bmpr1bb / bone morphogenetic protein receptor, type IBb / BMPR1B* / O00238* / bone morphogenetic protein receptor type 1B*ENSDARG0000010274248
bmpr1ab / bone morphogenetic protein receptor, type IAb / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSDARG0000010504548
acvr1l / activin A receptor, type 1 like / ACVR1* / Q04771* / P37172* / activin A receptor type 1* / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA.*ENSDARG0000001498646
acvrl1 / activin A receptor like type 1 / P37023* / Q61288* / Serine/threonine-protein kinase receptor R3 *ENSDARG0000001817945
acvr2bb / activin A receptor type 2Bb / ACVR2B* / Q13705* / activin A receptor type 2B*ENSDARG0000010310830
acvr2aa / activin A receptor type 2Aa / P27038* / ACVR2A* / P27037* / Activin receptor type-2A * / activin A receptor type 2A*ENSDARG0000001118829
tgfbr2b / transforming growth factor beta receptor 2b / Q62312* / TGFBR2* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*ENSDARG0000003454129
tgfbr2a / transforming growth factor beta receptor 2a / P37173* / TGFBR2* / transforming growth factor beta receptor 2*ENSDARG0000005936328
si:dkey-101k6.5ENSDARG0000005513628
bmpr2a / bone morphogenetic protein receptor, type II a (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*ENSDARG0000001194126
acvr2ba / activin A receptor type 2Ba / Q13705* / ACVR2B* / P27040* / Activin receptor type-2B * / activin A receptor type 2B*ENSDARG0000004442226
acvr2ab / activin A receptor type 2Ab / ACVR2A* / P27037* / activin A receptor type 2A*ENSDARG0000010470025
bmpr2b / bone morphogenetic protein receptor, type II b (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*ENSDARG0000002005725


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000472  Activin types I and II receptor domain
 IPR000719  Protein kinase domain
 IPR003605  GS domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001706 endoderm formation IGI
 biological_processGO:0001707 mesoderm formation IDA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0007493 endodermal cell fate determination IDA
 biological_processGO:0009953 dorsal/ventral pattern formation IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0031101 fin regeneration IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Signaling by Activin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain apoptotic , abnormal
brain quality , abnormal
Show

 ZFA:0000029 hindbrain hindbrain morphology , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary aplastic , abnormal
midbrain hindbrain boundary morphology , abnormal
midbrain hindbrain boundary structure , abnormal
midbrain hindbrain boundary quality , abnormal
Show

 ZFA:0000100 cerebellum cerebellum apoptotic , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000128 midbrain midbrain apoptotic , abnormal
Show

 ZFA:0000445 optic tectum optic tectum apoptotic , abnormal
Show

 ZFA:0001094 whole organism whole organism edematous , abnormal
Show

 ZFA:0001114 head head morphology , abnormal
Show

 ZFA:0001259 forebrain ventricle forebrain ventricle increased size , abnormal
Show

 ZFA:0001269 regenerating fin regenerating fin decreased length , abnormal
Show

 ZFA:0001442 upper rhombic lip upper rhombic lip aplastic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011188 acvr2aa / activin A receptor type 2Aa / P27038* / ACVR2A* / P27037* / Activin receptor type-2A * / activin A receptor type 2A*  / reaction / complex
 ENSDARG00000040777 inhbb / inhibin, beta B / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*  / reaction / complex
 ENSDARG00000036096 smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *  / reaction
 ENSDARG00000006389 smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *  / reaction
 ENSDARG00000104700 acvr2ab / activin A receptor type 2Ab / ACVR2A* / P27037* / activin A receptor type 2A*  / reaction / complex
 ENSDARG00000018968 acvr1ba / activin A receptor type 1Ba / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*  / reaction / complex
 ENSDARG00000044422 acvr2ba / activin A receptor type 2Ba / Q13705* / ACVR2B* / P27040* / Activin receptor type-2B * / activin A receptor type 2B*  / reaction / complex
 ENSDARG00000012671 inhbaa / inhibin, beta Aa / INHBA* / P08476* / inhibin beta A subunit*  / reaction / complex
 ENSDARG00000103892 CABZ01074203.1 / INHBB* / P09529* / inhibin beta B subunit*  / reaction / complex
 ENSDARG00000103108 acvr2bb / activin A receptor type 2Bb / ACVR2B* / Q13705* / activin A receptor type 2B*  / complex / reaction
 ENSDARG00000052142 acvr1bb / activin A receptor type 1Bb / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr