ENSDARG00000006389


Danio rerio

Features
Gene ID: ENSDARG00000006389
  
Biological name :smad2
  
Synonyms : Q9I9P9 / smad2 / SMAD family member 2
  
Possible biological names infered from orthology : Mothers against decapentaplegic homolog 2 / Q15796 / Q62432
  
Species: Danio rerio
  
Chr. number: 10
Strand: -1
Band:
Gene start: 14871136
Gene end: 14943281
  
Corresponding Affymetrix probe sets: Dr.22703.1.A1_at (Zebrafish Array)   Dr.8285.1.S1_a_at (Zebrafish Array)   NM_131366_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000120507
Ensembl peptide - ENSDARP00000145128
Ensembl peptide - ENSDARP00000120637
Ensembl peptide - ENSDARP00000044755
Ensembl peptide - ENSDARP00000106756
Ensembl peptide - ENSDARP00000111803
Ensembl peptide - ENSDARP00000117374
NCBI entrez gene - 30639     See in Manteia.
RefSeq - NM_131366
RefSeq - NM_001290015
RefSeq Peptide - NP_001276944
RefSeq Peptide - NP_571441
swissprot - E9QJE3
swissprot - E9QE59
swissprot - F1Q5P5
swissprot - Q9I9P9
ZFIN ID - ZDB-GENE-990603-7
Ensembl - ENSDARG00000006389
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000014184Gallus gallus
 SMAD2ZENSGALG00000036001Gallus gallus
 SMAD2ENSG00000175387Homo sapiens
 Smad2ENSMUSG00000024563Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *ENSDARG0000003609683
smad3b / SMAD family member 3b / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *ENSDARG0000001020781
smad5 / Q9W7E7 / SMAD family member 5 / SMAD1* / Q99717* / P97454* / Q15797* / P70340* / SMAD family member 1* / Mothers against decapentaplegic homolog 5 *ENSDARG0000003723861
alg5 / smad9 / SMAD family member 9 / O15198* / Q9JIW5* / Mothers against decapentaplegic homolog 9 *ENSDARG0000002193859
smad1 / SMAD family member 1 / SMAD5* / Q99717* / P70340* / P97454* / Q15797* / SMAD family member 5* / Mothers against decapentaplegic homolog 5 *ENSDARG0000002719959
smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*ENSDARG0000007522638
si:dkey-222b8.1ENSDARG0000004509438
si:dkey-222b8.1 / si:dkey-239n17.4ENSDARG0000007042837
smad6b / SMAD family member 6b / SMAD6* / O43541* / O35182* / SMAD family member 6* / Mothers against decapentaplegic homolog 6 *ENSDARG0000003176325
gb:cr929477 / expressed sequence CR929477ENSDARG0000001264925
smad6a / SMAD family member 6aENSDARG0000005320924
smad7 / SMAD family member 7 / O15105* / O35253*ENSDARG0000001685822


Protein motifs (from Interpro)
Interpro ID Name
 IPR001132  SMAD domain, Dwarfin-type
 IPR003619  MAD homology 1, Dwarfin-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013019  MAD homology, MH1
 IPR013790  Dwarfin
 IPR017855  SMAD-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IPI
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IGI
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009880 embryonic pattern specification IMP
 biological_processGO:0021999 neural plate anterior/posterior regionalization IGI
 biological_processGO:0035556 intracellular signal transduction IGI
 biological_processGO:0060282 positive regulation of oocyte development IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
Signaling by Activin
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta morphology , abnormal
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 ZFA:0000017 endoderm endoderm absent , abnormal
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 ZFA:0000022 floor plate floor plate aplastic , abnormal
floor plate absent , abnormal
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 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm increased size , abnormal
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 ZFA:0000477 posterior cardinal vein posterior cardinal vein morphology , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism increased curvature , abnormal
whole organism anterior-posterior axis curved , abnormal
whole organism anterior-posterior axis shortened , abnormal
whole organism anterior region truncated , abnormal
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 ZFA:0001114 head head anterior-most region truncated , abnormal
head mesoderm absent , abnormal
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 ZFA:0001115 trunk trunk mesoderm absent , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature morphology , abnormal
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 ZFA:0009248 neuron neuron degenerate , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000016496 cdk8 / cyclin-dependent kinase 8 / P49336* / Q8R3L8*  / reaction
 ENSDARG00000018968 acvr1ba / activin A receptor type 1Ba / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*  / reaction
 ENSDARG00000036096 smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *  / complex / reaction
 ENSDARG00000019293 tfdp1a / transcription factor Dp-1, a / TFDP1* / TFDP3* / Q14186* / Q5H9I0* / Q08639* / transcription factor Dp-1* / transcription factor Dp family member 3*  / reaction / complex
 ENSDARG00000075226 smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*  / complex / reaction
 ENSDARG00000019529 parp1 / poly (ADP-ribose) polymerase 1 / P09874* / poly (ADP-ribose) polymerase family, member 1*  / reaction / complex
 ENSDARG00000008034 skib / v-ski avian sarcoma viral oncogene homolog b / SKI* / P12755* / SKI proto-oncogene*  / complex / reaction
 ENSDARG00000055630 foxh1 / forkhead box H1 / O75593* / O88621* / Forkhead box protein H1 *  / complex / reaction
 ENSDARG00000016181 trim33 / tripartite motif containing 33 / Q9UPN9*  / complex / reaction
 ENSDARG00000059337 tgif1 / TGFB-induced factor homeobox 1 / P70284* / Q15583*  / complex / reaction
 ENSDARG00000038067 A9JRZ0 / smurf2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *  / complex / reaction
 ENSDARG00000015427 hdac1 / histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / reaction / complex
 ENSDARG00000006389 smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *  / reaction / complex
 ENSDARG00000101578 e2f4 / E2F transcription factor 4 / Q16254*  / complex / reaction
 ENSDARG00000059363 tgfbr2a / transforming growth factor beta receptor 2a / P37173* / TGFBR2* / transforming growth factor beta receptor 2*  / reaction
 ENSDARG00000017494 tgfbr1a / transforming growth factor, beta receptor 1 a / Q64729* / TGFBR1* / P36897* / transforming growth factor beta receptor 1* / transforming growth factor, beta receptor I*  / reaction
 ENSDARG00000038812 e2f5 / E2F transcription factor 5 / Q15329* / Q61502* / Transcription factor E2F5 *  / complex / reaction
 ENSDARG00000034541 tgfbr2b / transforming growth factor beta receptor 2b / Q62312* / TGFBR2* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*  / reaction
 ENSDARG00000023933 skila / SKI-like proto-oncogene a / SKIL* / Q60665* / P12757* / SKI-like* / SKI like proto-oncogene*  / reaction / complex
 ENSDARG00000042259 tgfbr1b / transforming growth factor, beta receptor 1 b / P36897* / TGFBR1* / transforming growth factor beta receptor 1*  / reaction
 ENSDARG00000022904 skilb / SKI-like proto-oncogene b / SKIL* / Q60665* / P12757* / SKI-like* / SKI like proto-oncogene*  / complex / reaction
 ENSDARG00000034895 tgfb1b / transforming growth factor, beta 1b / TGFB1* / P04202* / P01137* / transforming growth factor beta 1*  / reaction
 ENSDARG00000067719 wwtr1 / WW domain containing transcription regulator 1 / Q9EPK5* / Q9GZV5*  / complex / reaction
 ENSDARG00000023058 foxo3a / forkhead box O3A / FOXO3* / O43524* / Q9WVH4* / forkhead box O3* / Forkhead box protein O3 *  / complex / reaction
 ENSDARG00000000966 ncor2 / nuclear receptor corepressor 2 / Q9WU42* / Q9Y618*  / complex / reaction
 ENSDARG00000052142 acvr1bb / activin A receptor type 1Bb / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*  / reaction
 ENSDARG00000036685 ccnt2a / cyclin T2a / CCNT2* / O60583* / Q7TQK0* / cyclin T2*  / reaction
 ENSDARG00000044811 cdk9 / cyclin-dependent kinase 9 (CDC2-related kinase) / P50750* / Q99J95* / cyclin dependent kinase 9*  / reaction
 ENSDARG00000086172 ACVR1C / activin A receptor type 1C / Q8NER5*  / reaction
 ENSDARG00000101903 zfyve9a / zinc finger, FYVE domain containing 9a / ZFYVE9* / O95405* / zinc finger FYVE-type containing 9* / zinc finger, FYVE domain containing 9*  / reaction






 

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