ENSDARG00000055630


Danio rerio

Features
Gene ID: ENSDARG00000055630
  
Biological name :foxh1
  
Synonyms : forkhead box H1 / foxh1
  
Possible biological names infered from orthology : Forkhead box protein H1 / O75593 / O88621
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 13722385
Gene end: 13730501
  
Corresponding Affymetrix probe sets: Dr.7743.1.S1_at (Zebrafish Array)   Dr.7743.1.S2_at (Zebrafish Array)   NM_131502_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000072485
Ensembl peptide - ENSDARP00000127073
NCBI entrez gene - 57930     See in Manteia.
RefSeq - NM_131502
RefSeq Peptide - NP_571577
swissprot - F1R6J3
ZFIN ID - ZDB-GENE-000616-15
Ensembl - ENSDARG00000055630
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FOXH1ENSG00000160973Homo sapiens
 Foxh1ENSMUSG00000033837Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
foxe3 / forkhead box E3 / FOXE1* / O00358* / Q13461* / Q8R2I0* / Q9QY14* / forkhead box E1* / Forkhead box protein E1 * / Forkhead box protein E3 *ENSDARG0000006289216
foxd2 / forkhead box D2 / FOXD1* / O35392* / O60548* / Q16676* / Q61345* / forkhead box D1* / Forkhead box protein D1 * / Forkhead box protein D2 *ENSDARG0000005813316
foxf1 / A1L1S5 / forkhead box F1 / Q61080* / Q12946* / Forkhead box protein F1 *ENSDARG0000001539915
foxd3 / forkhead box D3 / FOXD4* / Q9UJU5* / Q12950* / Q3SYB3* / Q5VV16* / Q60688* / Q6VB84* / Q8WXT5* / Q9NU39* / FOXD4L3* / FOXD4L4* / FOXD4L5* / FOXD4L6* / FOXD4L1* / forkhead box D4* / ...ENSDARG0000002103215
foxf2b / forkhead box F2b / FOXF2* / O54743* / Q12947* / forkhead box F2* / Forkhead box protein F2 *ENSDARG0000007038915
foxe1 / forkhead box E1 / FOXE3* / Q9QY14* / O00358* / Q13461* / Q8R2I0* / forkhead box E3* / Forkhead box protein E3 * / Forkhead box protein E1 *ENSDARG0000007926614
foxq1b / forkhead box Q1b / FOXQ1* / O70220* / Q9C009* / forkhead box Q1* / Forkhead box protein Q1 *ENSDARG0000005539514
foxf2a / forkhead box F2a / FOXF2* / O54743* / Q12947* / forkhead box F2* / Forkhead box protein F2 *ENSDARG0000001719514
foxd1 / forkhead box D1 / FOXD2* / Q61345* / O35392* / O60548* / Q16676* / forkhead box D2* / Forkhead box protein D2 * / Forkhead box protein D1 *ENSDARG0000002917914
foxd5 / forkhead box D5 / FOXD1* / FOXD2* / Q16676* / Q61345* / O35392* / O60548* / forkhead box D2* / forkhead box D1* / Forkhead box protein D1 * / Forkhead box protein D2 *ENSDARG0000004248513
foxq1a / forkhead box Q1a / FOXQ1* / O70220* / Q9C009* / forkhead box Q1* / Forkhead box protein Q1 *ENSDARG0000003089613
zgc:162612 / FOXD1* / FOXD2* / O60548* / Q61345* / Q16676* / O35392* / forkhead box D1* / forkhead box D2* / Forkhead box protein D1 * / Forkhead box protein D2 *ENSDARG0000007969913
foxg1a / forkhead box G1a / FOXG1* / P55316* / Q60987* / Gm43517* / forkhead box G1* / Forkhead box protein G1 *ENSDARG0000007076913
foxg1c / forkhead box G1cENSDARG0000006838012
foxg1b / forkhead box G1bENSDARG0000003270512
foxp2 / forkhead box P2ENSDARG0000000545311
foxg1d / forkhead box G1dENSDARG0000007005311
si:dkey-7e14.3 / Gm5294* / AC187653.1*ENSDARG0000008605511
foxq2 / forkhead box Q2ENSDARG0000007139410
foxp4 / forkhead box P4ENSDARG0000007612010


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR030456  Fork head domain conserved site 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
Signaling by Activin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
brain quality , abnormal
Show

 ZFA:0000012 central nervous system central nervous system ventral region decreased size , abnormal
Show

 ZFA:0000022 floor plate floor plate quality , abnormal
floor plate absent , abnormal
floor plate aplastic , abnormal
floor plate decreased size , abnormal
floor plate ventral region hypoplastic , abnormal
Show

 ZFA:0000032 hypothalamus hypothalamus decreased size , abnormal
Show

 ZFA:0000038 margin margin decreased amount , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000060 prechordal plate prechordal plate morphology , abnormal
Show

 ZFA:0000071 shield shield absent , abnormal
shield poorly differentiated , abnormal
Show

 ZFA:0000075 spinal cord spinal cord morphology , abnormal
Show

 ZFA:0000091 axial chorda mesoderm axial chorda mesoderm aplastic , abnormal
axial chorda mesoderm morphology , abnormal
Show

 ZFA:0000106 extension extension decreased length , abnormal
extension increased thickness , abnormal
Show

 ZFA:0000107 eye eye fused with eye , abnormal
eye decreased distance eye , abnormal
eye mislocalised medially , abnormal
eye quality , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle anterior region absent , abnormal
Show

 ZFA:0000111 germ ring germ ring poorly differentiated , abnormal
Show

 ZFA:0000115 heart rudiment heart rudiment cardioblast anterior-lateral migration process quality , abnormal
Show

 ZFA:0000128 midbrain midbrain posterior region increased amount , abnormal
Show

 ZFA:0000135 notochord notochord aplastic , abnormal
notochord morphology , abnormal
notochord nucleus decreased amount , abnormal
notochord structure , abnormal
notochord curved ventral , abnormal
notochord decreased size , abnormal
notochord bent , abnormal
notochord cell morphology , abnormal
Show

 ZFA:0000155 somite somite fused with somite , abnormal
Show

 ZFA:0000360 heart tube heart tube centered , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000543 medial longitudinal fasciculus medial longitudinal fasciculus fused with medial longitudinal fasciculus , abnormal
medial longitudinal fasciculus axon disorganized , abnormal
Show

 ZFA:0000600 cranial nerve IV cranial nerve IV fused with cranial nerve IV , abnormal
Show

 ZFA:0000938 central canal central canal absent , abnormal
Show

 ZFA:0001094 whole organism whole organism dead , abnormal
whole organism anterior-posterior axis curved ventral , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism increased amount , abnormal
whole organism decreased amount , abnormal
whole organism shape , abnormal
Show

 ZFA:0001114 head head hypoplastic , abnormal
Show

 ZFA:0001115 trunk trunk curved ventral , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved , abnormal
post-vent region curved ventral , abnormal
Show

 ZFA:0001120 neuroectoderm neuroectoderm morphology , abnormal
Show

 ZFA:0001135 neural tube neural tube quality , abnormal
Show

 ZFA:0001218 presumptive floor plate presumptive floor plate cell decreased amount , abnormal
presumptive floor plate cell undifferentiated , abnormal
Show

 ZFA:0001258 floor plate rhombomere region floor plate rhombomere region aplastic , abnormal
Show

 ZFA:0001378 axial hypoblast axial hypoblast absent , abnormal
Show

 ZFA:0001423 parachordal cartilage parachordal cartilage fused with parachordal cartilage , abnormal
Show

 ZFA:0001424 chondrocranium chondrocranium morphology , abnormal
Show

 ZFA:0001507 trabecula cranii trabecula cranii fused with trabecula cranii , abnormal
Show

 ZFA:0001724 presumptive endocardium presumptive endocardium BMP signaling pathway involved in heart development decreased process quality , abnormal
Show

 ZFA:0007016 anterior neural plate anterior neural plate morphology , abnormal
Show

 ZFA:0009003 cranial neural crest cell cranial neural crest cell mislocalised ventrally , abnormal
Show

 ZFA:0009247 secondary motor neuron secondary motor neuron axon decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000036096 smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *  / reaction / complex
 ENSDARG00000006389 smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSDARG00000041203 drap1 / DR1-associated protein 1 (negative cofactor 2 alpha) / Q14919* / Q9D6N5* / DR1 associated protein 1* / Dr1-associated corepressor *  / complex
 ENSDARG00000075226 smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*  / reaction / complex






 

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