ENSG00000160973


Homo sapiens

Features
Gene ID: ENSG00000160973
  
Biological name :FOXH1
  
Synonyms : forkhead box H1 / FOXH1 / O75593
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q24.3
Gene start: 144473412
Gene end: 144476335
  
Corresponding Affymetrix probe sets: 207644_at (Human Genome U133 Plus 2.0 Array)   231407_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000366534
NCBI entrez gene - 8928     See in Manteia.
OMIM - 603621
RefSeq - NM_003923
RefSeq Peptide - NP_003914
swissprot - O75593
Ensembl - ENSG00000160973
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxh1ENSDARG00000055630Danio rerio
 Foxh1ENSMUSG00000033837Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FOXF2 / Q12947 / forkhead box F2ENSG0000013727322
FOXE3 / Q13461 / forkhead box E3ENSG0000018679022
FOXD2 / O60548 / forkhead box D2ENSG0000018656422
FOXE1 / O00358 / forkhead box E1ENSG0000017891921
FOXD1 / Q16676 / forkhead box D1ENSG0000025149321
FOXQ1 / Q9C009 / forkhead box Q1ENSG0000016437919
FOXF1 / Q12946 / forkhead box F1ENSG0000010324119
FOXD3 / Q9UJU5 / forkhead box D3ENSG0000018714018
FOXG1 / P55316 / forkhead box G1ENSG0000017616518
Q8WXT5 / FOXD4L4 / forkhead box D4 like 4ENSG0000018465917
Q6VB84 / FOXD4L3 / forkhead box D4 like 3ENSG0000018755917
FOXD4 / Q12950 / forkhead box D4ENSG0000017012217
Q3SYB3 / FOXD4L6 / forkhead box D4 like 6ENSG0000027351417
Q5VV16 / FOXD4L5 / forkhead box D4 like 5ENSG0000020477917
Q9NU39 / FOXD4L1 / forkhead box D4 like 1ENSG0000018449216
FOXP4 / Q8IVH2 / forkhead box P4ENSG0000013716616
AC187653.1ENSG0000024876714
FOXP1 / Q9H334 / forkhead box P1ENSG0000011486114
FOXP2 / O15409 / forkhead box P2ENSG0000012857313
FOXP3 / Q9BZS1 / forkhead box P3ENSG0000004976810


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0003139 secondary heart field specification IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0003215 cardiac right ventricle morphogenesis IEA
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0033147 negative regulation of intracellular estrogen receptor signaling pathway IDA
 biological_processGO:0035054 embryonic heart tube anterior/posterior pattern specification IEA
 biological_processGO:0035909 aorta morphogenesis IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048318 axial mesoderm development IEA
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway IDA
 biological_processGO:0071345 cellular response to cytokine stimulus IMP
 biological_processGO:1900164 nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry NAS
 biological_processGO:2000824 negative regulation of androgen receptor activity IDA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0032444 activin responsive factor complex IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0035326 enhancer binding IC
 molecular_functionGO:0043425 bHLH transcription factor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0050681 androgen receptor binding IPI
 molecular_functionGO:0070410 co-SMAD binding IMP
 molecular_functionGO:0070412 R-SMAD binding IEA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
Signaling by Activin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000175550 DRAP1 / Q14919 / DR1 associated protein 1  / complex
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / reaction / complex
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / reaction / complex
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / reaction / complex






 

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