ENSMUSG00000033837


Mus musculus

Features
Gene ID: ENSMUSG00000033837
  
Biological name :Foxh1
  
Synonyms : Forkhead box protein H1 / Foxh1 / O88621
  
Possible biological names infered from orthology : forkhead box H1 / O75593
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 76668225
Gene end: 76669948
  
Corresponding Affymetrix probe sets: 10430066 (MoGene1.0st)   1422212_at (Mouse Genome 430 2.0 Array)   1422213_s_at (Mouse Genome 430 2.0 Array)   1437779_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036591
NCBI entrez gene - 14106     See in Manteia.
MGI - MGI:1347465
RefSeq - XM_006520436
RefSeq - NM_007989
RefSeq Peptide - NP_032015
swissprot - O88621
swissprot - Q0VEP8
Ensembl - ENSMUSG00000033837
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxh1ENSDARG00000055630Danio rerio
 FOXH1ENSG00000160973Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxd2 / O35392 / Forkhead box protein D2 / O60548* / forkhead box D2*ENSMUSG0000005521020
Foxf2 / O54743 / Forkhead box protein F2 / Q12947* / forkhead box F2*ENSMUSG0000003840220
Foxf1 / Q61080 / Forkhead box protein F1 / Q12946* / forkhead box F1*ENSMUSG0000004281219
Foxe3 / Q9QY14 / Forkhead box protein E3 / Q13461* / forkhead box E3*ENSMUSG0000004451819
Foxe1 / Q8R2I0 / Forkhead box protein E1 / O00358* / forkhead box E1*ENSMUSG0000007099018
Foxd1 / Q61345 / Forkhead box protein D1 / Q16676* / forkhead box D1*ENSMUSG0000007830217
Foxq1 / O70220 / Forkhead box protein Q1 / Q9C009* / forkhead box Q1*ENSMUSG0000003841517
Foxd3 / forkhead box D3 / Q9UJU5*ENSMUSG0000006726116
Foxd4 / Q60688 / Forkhead box protein D4 / Q9NU39* / Q12950* / Q3SYB3* / Q5VV16* / Q6VB84* / Q8WXT5* / FOXD4L3* / FOXD4L4* / FOXD4L5* / FOXD4L6* / FOXD4L1* / forkhead box D4* / forkhead bo...ENSMUSG0000005149016
Foxg1 / Q60987 / Forkhead box protein G1 / P55316* / forkhead box G1*ENSMUSG0000002095015
Foxp4 / Q9DBY0 / Forkhead box protein P4 / Q8IVH2* / forkhead box P4*ENSMUSG0000002399113
Foxp2 / P58463 / Forkhead box protein P2 / O15409* / forkhead box P2*ENSMUSG0000002956312
Foxp1 / P58462 / Mus musculus forkhead box P1 (Foxp1), transcript variant 4, mRNA.ENSMUSG0000003006712
Gm5294 / AC187653.1*ENSMUSG0000009450411
Foxp3 / Q99JB6 / Forkhead box protein P3 Forkhead box protein P3, C-terminally processed Forkhead box protein P3 41 kDa form / Q9BZS1* / forkhead box P3*ENSMUSG000000395219
Gm43517ENSMUSG000000899228


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003139 secondary heart field specification IMP
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0003215 cardiac right ventricle morphogenesis IMP
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0033147 negative regulation of intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0035054 embryonic heart tube anterior/posterior pattern specification IMP
 biological_processGO:0035909 aorta morphogenesis IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048318 axial mesoderm development IMP
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway IEA
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:2000824 negative regulation of androgen receptor activity IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0032444 activin responsive factor complex IDA
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IMP
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043425 bHLH transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046332 SMAD binding IPI
 molecular_functionGO:0050681 androgen receptor binding IEA
 molecular_functionGO:0070410 co-SMAD binding IEA
 molecular_functionGO:0070412 R-SMAD binding IDA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
Signaling by Activin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000024 lowered ear position "outer ears which are situated below the normal location " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ciarttm1a(KOMP)Wtsi/Ciart+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000087 absent mandible "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ciarttm1a(KOMP)Wtsi/Ciart+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Ciarttm1a(KOMP)Wtsi/Ciart+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ciarttm1a(KOMP)Wtsi/Ciart+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ciarttm1a(KOMP)Wtsi/Ciart+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Ciarttm1a(KOMP)Wtsi/Ciart+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000508 right-sided isomerism "the relative symmetry of the organs of the thorax and abdomen as indicated by both atria displaying the morphology of the right atrium" [J:58530, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0000531 right pulmonary isomerism "bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530]
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Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0000644 dextrocardia "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0000650 mesocardia "cardiac apex pointing to the middle as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0000690 absent spleen "missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Ciarttm1a(KOMP)Wtsi/Ciart+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0000932 absent notochord "missing axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Ciarttm1a(KOMP)Wtsi/Ciart+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Ciarttm1a(KOMP)Wtsi/Ciart+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001890 anencephaly "absence of the bones of the cranial vault and absent or rudimentary cerebral and cerebellar hemispheres, brainstem, and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:31571]
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Allelic Composition: Ciarttm1a(KOMP)Wtsi/Ciart+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0002672 abnormal branchial arch artery morphology "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0003104 acrania "complete or partial absence of a skull; usually associated with anencephaly" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:33716]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0003388 absent pericardium "absence of the fibroserous membrane covering the heart and beginning of the great vessels" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0003872 absent right ventricle "missing the lower right chamber of the heart" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0003924 herniated diaphragm "protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0004733 abnormal thoracic cavity "any structural anomaly of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0005163 cyclopia "a congenital defect in which the two orbits are united to form a single cavity containing one eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60303]
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Allelic Composition: Ciarttm1a(KOMP)Wtsi/Ciart+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0006061 right atrial isomerism "altered asymmetric patterning of the atria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0006063 abnormal inferior vena cava morphology "structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0006065 abnormal heart position "the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0006290 proboscis "a long, cylindric protuberance of the face that, in cyclopia or ethmocephaly, represents the nose" [J:92058, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0009266 abnormal mesendoderm development "failure or abnormality in the formation of the embryonic cell layer that gives rise to both the endoderm and mesoderm" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0009331 absent primitive node "absence of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorally to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0009880 microstomia "abnormally decreased size of the mouth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0010406 absent atrial septum "absence of the thin membranous structure between the two heart atria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0010413 complete atrioventricular septal defect "a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com]
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Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0010431 atrial situs inversus "anomaly in the asymmetry of the cardiac atria such that atria on both the left and right side have the morphology normally seen on the opposite side of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0010432 common ventricle "the presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0010446 heart left ventricle hypoplasia "underdevelopment or reduced size of the heart left ventricle, often due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0010466 vascular ring "the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches" [http://emedicine.medscape.com]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0010487 abnormal right subclavian artery morphology "any structural anomaly of the artery that normally extends from the brachiocephalic artery to the right side of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0010668 abnormal hepatic portal vein morphology "any structural anomaly of the wide short vein formed from the confluence of the superior mesenteric, inferior mesenteric and splenic veins, and then divides into the right and left branches which ramify with the liver; the hepatic portal vein carries venous blood from the GI tract, spleen and pancreas to the liver" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0010808 right-sided stomach "stomach is present on the right side of the body instead of the left" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0011250 abdominal situs ambiguus "an abnormality in which the abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements" [MGI:csmith, PMID:18039396]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0011253 situs inversus with levocardia "situs inversus of thoracic and abdominal viscera with the heart remaining normally situated on the left; usually associated with congenital cardiac abnormalities such as transposition of the great vessels and/or spleen defects including asplenia or polysplenia" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0011323 abnormal renal vein morphology "any structural anomaly of the pair of major vessels which arise from the renal hilus and return blood from the kidneys, suprarenal gland and the ureter to the inferior vena cava" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0011569 abnormal azygos vein morphology "any structural anomaly of the unpaired vein which in humans arises from the right ascending lumbar vein or the vena cava, enters the thorax through the aortic orifice in the diaphragm, and terminates in the superior vena cava; unlike humans, mice have a single and left-sided azygos vein that develops from the paired embryonic cardinal venous system and drains most of the right and left thoracic walls into the left anterior vena cava" [MGI:anna]
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Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0011667 double outlet right ventricle with atrioventricular septal defect "a form of DORV in which there is also a complete atrioventricular canal" [MGI:csmith]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0011668 double outlet right ventricle, Taussig bing type "a form of DORV in which blood from the left ventricle passes through a ventricular septal defect to the pulmonary artery, and blood from the right ventricle is directed to the aorta" [MGI:csmith]
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Allelic Composition: Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic Background: C57BL/6J-Foxh1b2b2662Clo

 MP:0011733 fused somites "a defect in which there is an appearance of a single enlarged somite resulting from partial or complete fusion of the two somitic anlage" [MGI:smb]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0012135 embryonic-extraembryonic boundary constriction "an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm" [MGI:csmith]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0012165 absent neural folds "absence of the elevated margins of the neural groove" [MGI:csmith]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0012276 absent prechordal mesoderm "absence of or failure to form the area of axial mesoderm that develops into the prechordal plate" [MGI:anna]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0012501 abnormal pericardial cavity morphology "any structural anomaly of the anatomical body cavity in which the heart lies; the pericardial cavity forms in the lateral plate mesoderm above the buccopharyngeal membrane, as part of the early intraembryonic coelom, and is initially continuous with the two early pleural cavities" [MGI:anna]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0012739 abnormal anterior primitive streak morphology "any structural anomaly of the anterior region of the vertebrate primitive streak which gives rise to the axial and paraxial mesoderm, the definitive endoderm, the primitive groove, and the primitive node" [MGI:anna]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0030324 abnormal anterior head development "any anomaly in the process in which the anatomical structures of the anterior part of the head are generated and organized" [GO:0097065, MGI:anna]
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Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / complex / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / complex / reaction
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / reaction / complex
 ENSMUSG00000024914 Drap1 / Q9D6N5 / Dr1-associated corepressor / Q14919* / DR1 associated protein 1*  / complex






 

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