ENSMUSG00000078302


Mus musculus

Features
Gene ID: ENSMUSG00000078302
  
Biological name :Foxd1
  
Synonyms : Forkhead box protein D1 / Foxd1 / Q61345
  
Possible biological names infered from orthology : forkhead box D1 / Q16676
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: D1
Gene start: 98354242
Gene end: 98359305
  
Corresponding Affymetrix probe sets: 10406845 (MoGene1.0st)   1418876_at (Mouse Genome 430 2.0 Array)   1418877_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100725
NCBI entrez gene - 15229     See in Manteia.
MGI - MGI:1347463
RefSeq - NM_008242
RefSeq Peptide - NP_032268
swissprot - Q61345
Ensembl - ENSMUSG00000078302
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxd1ENSDARG00000029179Danio rerio
 foxd2ENSDARG00000058133Danio rerio
 foxd5ENSDARG00000042485Danio rerio
 zgc:162612ENSDARG00000079699Danio rerio
 FOXD1ENSG00000251493Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxd2 / O35392 / Forkhead box protein D2 / O60548* / forkhead box D2*ENSMUSG0000005521044
Foxd3 / forkhead box D3 / Q9UJU5*ENSMUSG0000006726140
Foxd4 / Q60688 / Forkhead box protein D4 / Q9NU39* / Q12950* / Q3SYB3* / Q5VV16* / Q6VB84* / Q8WXT5* / FOXD4L3* / FOXD4L4* / FOXD4L5* / FOXD4L6* / FOXD4L1* / forkhead box D4* / forkhead bo...ENSMUSG0000005149030
Foxe1 / Q8R2I0 / Forkhead box protein E1 / O00358* / forkhead box E1*ENSMUSG0000007099024
Foxf2 / O54743 / Forkhead box protein F2 / Q12947* / forkhead box F2*ENSMUSG0000003840223
Foxg1 / Q60987 / Forkhead box protein G1 / P55316* / forkhead box G1*ENSMUSG0000002095023
Foxe3 / Q9QY14 / Forkhead box protein E3 / Q13461* / forkhead box E3*ENSMUSG0000004451823
Foxq1 / O70220 / Forkhead box protein Q1 / Q9C009* / forkhead box Q1*ENSMUSG0000003841521
Foxf1 / Q61080 / Forkhead box protein F1 / Q12946* / forkhead box F1*ENSMUSG0000004281219
Gm5294 / AC187653.1*ENSMUSG0000009450418
Foxp1 / P58462 / Mus musculus forkhead box P1 (Foxp1), transcript variant 4, mRNA.ENSMUSG0000003006715
Foxp2 / P58463 / Forkhead box protein P2 / O15409* / forkhead box P2*ENSMUSG0000002956315
Foxh1 / O88621 / Forkhead box protein H1 / O75593* / forkhead box H1*ENSMUSG0000003383715
Foxp4 / Q9DBY0 / Forkhead box protein P4 / Q8IVH2* / forkhead box P4*ENSMUSG0000002399114
Gm43517ENSMUSG0000008992211
Foxp3 / Q99JB6 / Forkhead box protein P3 Forkhead box protein P3, C-terminally processed Forkhead box protein P3 41 kDa form / Q9BZS1* / forkhead box P3*ENSMUSG000000395219


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IDA
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030513 positive regulation of BMP signaling pathway IMP
 biological_processGO:0032275 luteinizing hormone secretion IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching IMP
 biological_processGO:0072076 nephrogenic mesenchyme development IMP
 biological_processGO:0072210 metanephric nephron development IMP
 biological_processGO:0072213 metanephric capsule development IMP
 biological_processGO:0072267 metanephric capsule specification IMP
 biological_processGO:0072268 pattern specification involved in metanephros development IMP
 biological_processGO:0090184 positive regulation of kidney development IMP
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008301 DNA binding, bending IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Six2-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CD-1

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0000528 delayed kidney development "late onset of the induction and/or differentiation of the kidney" [J:18048]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0000639 abnormal adrenal gland morphology "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0002768 small adrenal glands "reduced size of endocrine glands located above the kidneys responsible for hormone and epinephrine secretion" [J:78062]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0002990 short ureter "reduced length of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0003605 fused kidneys 
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0003881 abnormal nephron morphology "malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of henle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:71588]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0005426 tachypnea "rapid breathing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0009247 meteorism "swelling of the abdomen resulting from gas in the intestinal or peritoneal cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0010984 abnormal metanephric mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:19828308]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0010987 abnormal nephrogenic mesenchyme morphogenesis "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing nephron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0011334 abnormal nephrogenic zone morphology "any structural anomaly in the region found at the periphery of the developing metanephros within which the metanephric mesenchyme aggregates around the tips of the ureteric tree to form the nephrons; in rodents including mice, this region normally disappears within the first postnatal week when nephrogenesis ceases and only mature nephrons are present; in humans, it is lost by 36 weeks of gestation" [PMID:17452023]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0011361 pelvic kidney "an ectopic kidney located outside the renal fossa and within the pelvic cavity; pelvic kidneys may also, on occasion, occur as fused midline horseshoe kidneys" [MGI:anna]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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