Manteia - Molecule gene

ENSMUSG00000067261

Mus musculus

Features

Gene ID:	ENSMUSG00000067261

Biological name :	Foxd3

Synonyms :	forkhead box D3 / Foxd3

Possible biological names infered from orthology :	Q9UJU5

Species:	Mus musculus

Chr. number:	4
Strand:	1
Band:	C6
Gene start:	99656299
Gene end:	99658622

Corresponding Affymetrix probe sets:	10506150 (MoGene1.0st) 1422210_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000084541 NCBI entrez gene - 15221 See in Manteia. MGI - MGI:1347473 RefSeq - NM_010425 RefSeq Peptide - NP_034555 swissprot - A2BDY3 Ensembl - ENSMUSG00000067261

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
foxd3	ENSDARG00000021032	Danio rerio
FOXD3	ENSG00000187140	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Foxd1 / Q61345 / Forkhead box protein D1 / Q16676* / forkhead box D1*	ENSMUSG00000078302	39
Foxd2 / O35392 / Forkhead box protein D2 / O60548* / forkhead box D2*	ENSMUSG00000055210	37
Foxd4 / Q60688 / Forkhead box protein D4 / Q9NU39* / Q12950* / Q3SYB3* / Q5VV16* / Q6VB84* / Q8WXT5* / FOXD4L3* / FOXD4L4* / FOXD4L5* / FOXD4L6* / FOXD4L1* / forkhead box D4* / forkhead bo...	ENSMUSG00000051490	30
Foxg1 / Q60987 / Forkhead box protein G1 / P55316* / forkhead box G1*	ENSMUSG00000020950	23
Foxf2 / O54743 / Forkhead box protein F2 / Q12947* / forkhead box F2*	ENSMUSG00000038402	23
Foxe3 / Q9QY14 / Forkhead box protein E3 / Q13461* / forkhead box E3*	ENSMUSG00000044518	22
Foxe1 / Q8R2I0 / Forkhead box protein E1 / O00358* / forkhead box E1*	ENSMUSG00000070990	22
Foxq1 / O70220 / Forkhead box protein Q1 / Q9C009* / forkhead box Q1*	ENSMUSG00000038415	21
Foxf1 / Q61080 / Forkhead box protein F1 / Q12946* / forkhead box F1*	ENSMUSG00000042812	19
Gm5294 / AC187653.1*	ENSMUSG00000094504	19
Foxp2 / P58463 / Forkhead box protein P2 / O15409* / forkhead box P2*	ENSMUSG00000029563	16
Foxp1 / P58462 / Mus musculus forkhead box P1 (Foxp1), transcript variant 4, mRNA.	ENSMUSG00000030067	14
Foxh1 / O88621 / Forkhead box protein H1 / O75593* / forkhead box H1*	ENSMUSG00000033837	14
Foxp4 / Q9DBY0 / Forkhead box protein P4 / Q8IVH2* / forkhead box P4*	ENSMUSG00000023991	14
Foxp3 / Q99JB6 / Forkhead box protein P3 Forkhead box protein P3, C-terminally processed Forkhead box protein P3 41 kDa form / Q9BZS1* / forkhead box P3*	ENSMUSG00000039521	10
Gm43517	ENSMUSG00000089922	10

Protein motifs (from Interpro)

Interpro ID	Name
IPR001766	Fork head domain
IPR018122	Fork head domain conserved site1
IPR030456	Fork head domain conserved site 2
IPR036388	Winged helix-like DNA-binding domain superfamily
IPR036390	Winged helix DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
cellular_component	GO:0000790	nuclear chromatin	IEA
cellular_component	GO:0005634	nucleus	IEA
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IEA
molecular_function	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000088	short mandible	"reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0000091	short premaxilla	"reduced length of the anterior and interior portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0000097	short maxilla	"reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0000108	midline facial cleft	"incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0000111	cleft palate	"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Id2^tm1Ago/Id2^tm1Ago Genetic Background: B6.129-Id2^tm1Ago
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0000350	abnormal cell proliferation	"anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Foxd3^tm1.1Lby/Foxd3^tm1.1Lby Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * CD-1) Allelic Composition: Foxd3^tm2Lby/Foxd3^tm2Lby Genetic Background: involves: 129S6/SvEvTac
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0000964	small dorsal root ganglia	"reduced size of the dorsal root ganglia" [J:17123]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0001044	abnormal enteric nervous system morphology	"malformation or absence of the part of the autonomic nervous system that innervates the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0001077	abnormal spinal nerve morphology	"any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0001302	eyelids open at birth	"widely open eyes instead of closed at perinatal stage" [J:51966]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0001683	absent mesoderm	"missing or failure to differentiate the middle primary germ layer " [J:40594]	Show Allelic Composition: Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001693	failure of primitive streak formation	"inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]	Show Allelic Composition: Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Foxd3^tm1.1Lby/Foxd3^tm1.1Lby Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * CD-1) Allelic Composition: Foxd3^tm2Lby/Foxd3^tm2Lby Genetic Background: involves: 129S6/SvEvTac
MP:0001696	failure to gastrulate	"inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]	Show Allelic Composition: Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Foxd3^tm1.1Lby/Foxd3^tm1.1Lby Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * CD-1) Allelic Composition: Foxd3^tm2Lby/Foxd3^tm2Lby Genetic Background: involves: 129S6/SvEvTac
MP:0001705	abnormal proximal-distal axis patterning	"anomaly in the formation or development of a body structure, often a limb, in relation to the structure s proximity to the trunk or point of origin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Foxd3^tm1.1Lby/Foxd3^tm1.1Lby Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * CD-1) Allelic Composition: Foxd3^tm2Lby/Foxd3^tm2Lby Genetic Background: involves: 129S6/SvEvTac
MP:0001716	abnormal placental labyrinth	"malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm2Lby Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Foxd3^tm1Lby/Foxd3^tm1Lby Genetic Background: involves: 129S6/SvEvTac * CD-1
MP:0001724	abnormal extraembryonic endoderm formation	"malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628]	Show Allelic Composition: Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Foxd3^tm1.1Lby/Foxd3^tm1.1Lby Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * CD-1) Allelic Composition: Foxd3^tm2Lby/Foxd3^tm2Lby Genetic Background: involves: 129S6/SvEvTac
MP:0001953	respiratory failure	"cessation of or failure to commence breathing" [MGI:cls, J:60159]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0002084	abnormal developmental patterning	"abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Foxd3^tm1.1Lby/Foxd3^tm1.1Lby Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * CD-1) Allelic Composition: Foxd3^tm2Lby/Foxd3^tm2Lby Genetic Background: involves: 129S6/SvEvTac
MP:0002633	persistent truncus arteriosis	"complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0003886	abnormal embryonic epiblast morphology	"anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Foxd3^tm1.1Lby/Foxd3^tm1.1Lby Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * CD-1) Allelic Composition: Foxd3^tm2Lby/Foxd3^tm2Lby Genetic Background: involves: 129S6/SvEvTac
MP:0003994	abnormal dorsal spinal root morphology	"any anomaly, deformity, or malformation of the posterior bundle of nerves emerging from the spinal cord to join with the anterior/ventral nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0004376	absent frontal bone	"absence of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0004384	small interparietal bone	"reduced size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0004418	small parietal bone	"reduced size of the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0004447	small basioccipital bone	"reduced size of the bone in the base of the cranium, frequently forming a part of the occipital in the adult, but usually distinct in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0005031	abnormal trophoblast	"malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm2Lby Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Foxd3^tm1Lby/Foxd3^tm1Lby Genetic Background: involves: 129S6/SvEvTac * CD-1
MP:0006042	increased apoptosis	"greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0006346	small branchial arch	"reduced size of one or more of the branchial arches" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0008384	absent nasal capsule	"absence of the cartilage around the developing nasal cavity of the embryo" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0011091	complete prenatal lethality	"death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Foxd3^tm1.1Lby/Foxd3^tm1.1Lby Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * CD-1)
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Foxd3^tm2Lby/Foxd3^tm2Lby Genetic Background: involves: 129S6/SvEvTac
MP:0011189	small embryonic epiblast	"reduced size of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]	Show Allelic Composition: Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0011192	decreased embryonic epiblast cell proliferation	"reduction in the expansion rate of the embryonic epiblast cells by cell division" [MGI:anna]	Show Allelic Composition: Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0011255	abnormal anterior visceral endoderm cell migration	"any anomaly in the movement of the cells of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:csmith, PMID:17078044]	Show Allelic Composition: Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0012100	absent spongiotrophoblast	"absence of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm2Lby Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Foxd3^tm1Lby/Foxd3^tm1Lby Genetic Background: involves: 129S6/SvEvTac * CD-1
MP:0012261	increased hindbrain apoptosis	"increase in the number of cells of the hindbrain undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0012729	abnormal common carotid artery morphology	"any structural anomaly of the left or right common carotid arteries which extend headward on each side of the anterior neck and deliver oxygenated nutrient filled blood from the heart to the head, neck and brain; the left originates in the arch of the aorta over the heart; the right originates in the brachiocephalic trunk, the largest branch from the arch of the aorta; each common carotid artery divides into an external and an internal carotid artery" [MGI:anna]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0012752	abnormal cardiac neural crest cell migration	"any anomaly in the migratory path of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs which originate from the lower hindbrain between the otic placode and third somite and migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs undergo migration away from the neural tube by following a dorsolateral path under the ectoderm, leading them to the pharyngeal arches; after pausing, they resume migration under the pharyngeal endoderm and, along the aortic arch arteries, populate the cardiac OFT where they contribute the aorticopulmonary septum, and ultimately colonize the heart to form the ventricular septum and cardiac ganglia" [MGI:anna]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0013006	abnormal enteric neural crest cell migration	"any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise predominantly from the vagal (neck) region of the neural tube (vagal neural crest), adjacent to somites 1-7, and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut; NCCs are termed enteric neural crest-derived cells upon entering the foregut at E9-9.5 in mice (after 4 weeks gestation in humans) and the colonization process is complete by E15.5 (after 7 weeks gestation in humans)" [MGI:anna, PMID:17514199]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0030223	mandibular hyperostosis	"hyperostosis (bony overgrowth) of the mandible" [HP:0004472]	Show Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr