ENSMUSG00000020950


Mus musculus

Features
Gene ID: ENSMUSG00000020950
  
Biological name :Foxg1
  
Synonyms : Forkhead box protein G1 / Foxg1 / Q60987
  
Possible biological names infered from orthology : forkhead box G1 / P55316
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: B3
Gene start: 49382660
Gene end: 49386861
  
Corresponding Affymetrix probe sets: 10395596 (MoGene1.0st)   1418357_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021333
Ensembl peptide - ENSMUSP00000136372
NCBI entrez gene - 15228     See in Manteia.
MGI - MGI:1347464
RefSeq - NM_008241
RefSeq - NM_001160112
RefSeq Peptide - NP_001153584
RefSeq Peptide - NP_032267
swissprot - Q3V1Q8
swissprot - Q60987
Ensembl - ENSMUSG00000020950
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxg1aENSDARG00000070769Danio rerio
 FOXG1ENSGALG00000036364Gallus gallus
 FOXG1ENSG00000176165Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm43517ENSMUSG0000008992248
Foxd2 / O35392 / Forkhead box protein D2 / O60548* / forkhead box D2*ENSMUSG0000005521024
Foxd1 / Q61345 / Forkhead box protein D1 / Q16676* / forkhead box D1*ENSMUSG0000007830222
Foxd3 / forkhead box D3 / Q9UJU5*ENSMUSG0000006726122
Foxe1 / Q8R2I0 / Forkhead box protein E1 / O00358* / forkhead box E1*ENSMUSG0000007099019
Foxd4 / Q60688 / Forkhead box protein D4 / Q9NU39* / Q12950* / Q3SYB3* / Q5VV16* / Q6VB84* / Q8WXT5* / FOXD4L3* / FOXD4L4* / FOXD4L5* / FOXD4L6* / FOXD4L1* / forkhead box D4* / forkhead bo...ENSMUSG0000005149019
Foxf2 / O54743 / Forkhead box protein F2 / Q12947* / forkhead box F2*ENSMUSG0000003840219
Foxe3 / Q9QY14 / Forkhead box protein E3 / Q13461* / forkhead box E3*ENSMUSG0000004451817
Foxq1 / O70220 / Forkhead box protein Q1 / Q9C009* / forkhead box Q1*ENSMUSG0000003841516
Foxp1 / P58462 / Mus musculus forkhead box P1 (Foxp1), transcript variant 4, mRNA.ENSMUSG0000003006715
Gm5294 / AC187653.1*ENSMUSG0000009450415
Foxf1 / Q61080 / Forkhead box protein F1 / Q12946* / forkhead box F1*ENSMUSG0000004281215
Foxp4 / Q9DBY0 / Forkhead box protein P4 / Q8IVH2* / forkhead box P4*ENSMUSG0000002399114
Foxp2 / P58463 / Forkhead box protein P2 / O15409* / forkhead box P2*ENSMUSG0000002956314
Foxh1 / O88621 / Forkhead box protein H1 / O75593* / forkhead box H1*ENSMUSG0000003383713
Foxp3 / Q99JB6 / Forkhead box protein P3 Forkhead box protein P3, C-terminally processed Forkhead box protein P3 41 kDa form / Q9BZS1* / forkhead box P3*ENSMUSG0000003952111


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0002052 positive regulation of neuroblast proliferation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0016199 axon midline choice point recognition IMP
 biological_processGO:0021852 pyramidal neuron migration IDA
 biological_processGO:0021954 central nervous system neuron development IMP
 biological_processGO:0021987 cerebral cortex development IDA
 biological_processGO:0022008 neurogenesis IDA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0045666 positive regulation of neuron differentiation IGI
 biological_processGO:0045787 positive regulation of cell cycle IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0048664 neuron fate determination IDA
 biological_processGO:0048667 cell morphogenesis involved in neuron differentiation IMP
 biological_processGO:0051726 regulation of cell cycle IDA
 biological_processGO:2000177 regulation of neural precursor cell proliferation IGI
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Lmo4tm1Gan/Lmo4tm1Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lmo4tm2.1Gan/Lmo4tm2.1Gan,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Slc12a2tm1.1Jheb/Slc12a2tm1.1Jheb,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Jag1tm2.1Grid/Jag1tm2.1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000034 abnormal vestibule morphology "malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0000036 absent semicircular canals "missing organ of balance; consists of three bony tubes within which the semicircular ducts are located" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

Allelic Composition: Lmo4tm1Gan/Lmo4tm2.1Gan,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lmo4tm2.1Gan/Lmo4tm2.1Gan,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0000037 abnormal lateral semicircular canal "anomaly of the lateral long bony tube of the labyrinth that is involved in the sense of balance " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Jag1tm2.1Grid/Jag1tm2.1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000040 absent middle ear ossicles "missing small bones of the tympanic cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0000049 abnormal middle ear morphology "malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0000090 absent premaxilla "missing anterior and interior portion of the maxilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Gaktm2Legr/Gaktm2Legr,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Gaktm2Legr/Gaktm2Legr,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx3tm1Mlc/Pbx3+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Wnt9btm1Amc/Wnt9btm1Amc,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Pbx1tm1Mlc/Pbx1+,Wnt9btm1Amc/Wnt9btm1Amc,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il4ratm3.1Tch/Il4ratm3.1Tch
Genetic Background: C.129X1-Il4ratm3.1Tch

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0000680 absent parathyroid glands "missing the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland, which secrete parathyroid hormone (PTH) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0000705 athymia "absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000778 abnormal tract 
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000785 telencephalon hypoplasia "reduced cell number in cerebral cortex and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Gli2tm2.1Alj/Gli2+,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster

Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+,Frs2tm1Fwan/Frs2tm1Fwan,Frs3tm1Jheb/Frs3tm1Jheb
Genetic Background: involves: 129 * Swiss Webster

Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Foxg1tm1(cre)Skm/Foxg1+,Fgfr1tm1Jpa/Fgfr1tm1Jpa
Genetic Background: involves: 129

Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Foxg1tm1(cre)Skm/Foxg1+,Fgfr1tm3.1Sor/Fgfr1tm1Jpa
Genetic Background: involves: 129

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: B6.129P2-Foxg1tm1(cre)Skm

Allelic Composition: Foxg1tm1M/Foxg1tm1M
Genetic Background: involves: 129S1/Sv

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Top2btm2Jcw/Top2btm2.1Jcw,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: B6.129P2-Foxg1tm1(cre)Skm

 MP:0000789 thickened cerebral cortex "Increased depth of the mantle coveringthe surface of the cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:49481]
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Allelic Composition: Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000805 abnormal visual cortex morphology "malformation or absence of the area of the occipital cortex concerned with vision" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nbeal2gps/Nbeal2gps
Genetic Background: 129S1/SvImJ-Nbeal2gps

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Top2btm2Jcw/Top2btm2.1Jcw,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Sema3atm1.1Tyag/Sema3atm1.1Tyag,Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

 MP:0000814 absent dentate gyrus "lack of the section of the hippocampus normally situated above the gyrus hippocampi and composed of three layers, the molecular, granular, and polymorphic layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1+,Tg(tetO-Gsx2,-EGFP)1Kcam/0
Genetic Background: involves: 129S1/Sv

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Rhoatm1Yuyo/Rhoatm1Yuyo,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Rhoatm1Yuyo/Rhoatm1Yuyo,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rettm8(RET)Jmi/Rettm8(RET)Jmi
Genetic Background: involves: 129X1/SvJ * 129S1/Sv * C57BL/6

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdc42tm1Yizh/Cdc42tm1Yizh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1+,Tg(tetO-Gsx2,-EGFP)1Kcam/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000935 abnormal folding of telencephalic vesicles "malformation of the stereotypic invaginations forming the paired diverticula of the telencephalon" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Cdc42tm1Yizh/Cdc42tm1Yizh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000936 small telencephalic vesicles "reduced size of the paired diverticula of the telencephalon, from which the forebrain develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdc42tm1Yizh/Cdc42tm1Yizh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0001082 abnormal geniculate ganglion morphology "malformed group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001092 abnormal trigeminal ganglion morphology "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001096 abnormal glossopharyngeal ganglion morphology "malformed group of neuron cell bodies associated with the ninth cranial nerve" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001100 abnormal vagus ganglion morphology "malformed group of sensory neuron cell bodies associated with the vagus nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Top2btm2Jcw/Top2btm2.1Jcw,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Cdc42tm1Yizh/Cdc42tm1Yizh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg,Acer2em1Mvw/Acer2em1Mvw
Genetic Background: involves: C57BL/6J * C57BL/6NTac

Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Foxg1tm1(cre)Skm/Foxg1+,Fgfr1tm1Jpa/Fgfr1tm1Jpa
Genetic Background: involves: 129

Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Foxg1tm1(cre)Skm/Foxg1+,Fgfr1tm3.1Sor/Fgfr1tm1Jpa
Genetic Background: involves: 129

 MP:0001300 ocular hypertelorism "increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Slc12a2tm1.1Jheb/Slc12a2tm1.1Jheb,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Slc12a2K842*/Slc12a2K842*
Genetic Background: involves: FVB/N

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Bsndtm1Tjj/Bsndtm1Tjj,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Top2btm2Jcw/Top2btm2.1Jcw,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0001957 apnea "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]
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Allelic Composition: Mafbtm1.1Good/Mafbtm1Jeng,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adcyap1tm1Clw/Adcyap1tm1Clw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Spp1tm1Blh/Spp1+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm2.2Bem/Tbx1tm2.2Bem
Genetic Background: involves: 129/Sv * C57BL/6J * SJL * Swiss Webster

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: B6.129P2-Foxg1tm1(cre)Skm

Allelic Composition: Foxg1tm1M/Foxg1+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1+,Tg(tetO-Gsx2,-EGFP)1Kcam/0
Genetic Background: involves: 129S1/Sv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd4tm1Knw/Cd4tm1Knw
Genetic Background: B6.129S-Cd4tm1Knw/J

 MP:0002428 abnormal semicircular canal "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jag1tm1Jlew/Jag1tm1Jlew,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: C57BL/6J

Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Jag1tm1Jlew/Jag1tm1Jlew,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: C57BL/6J

Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Top2btm2Jcw/Top2btm2.1Jcw,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002878 abnormal corticospinal tract "anomaly in the structure or function of the fibers that arise from the cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gpamtm1.1Dali/Gpamtm1.1Dali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Braftm1Sva/Braftm1Sva,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002951 small thyroid gland "reduced size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0003069 abnormal superior semicircular canal "anomaly of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0003138 absent tympanic ring "missing the bony ring at the ear canal to which the tympanic membrane is attached" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:46972]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0003147 absent cochlea "absence or agenesis of the cochlea" [J:23837, J:36834, J:46972, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0003148 reduced cochlear coiling "a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [J:56294, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0003151 absent tunnel of Corti "complete absence of the triangular, fluid-filled space normally found between the inner and outer rows of supporting pillar cells in the organ of Corti" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:32991]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0003152 abnormal pillar cell differentiation "abnormal differentiation of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [J:32991, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pdyntm1Zim/Pdyntm1Zim
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003161 absent lateral semicircular canal 
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003162 reduced size of lateral semicircular canal 
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Allelic Composition: Chd7tm1.1Dmm/Chd7+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0003163 absent posterior semicircular canal 
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0003166 reduced size of superior semicircular canal 
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0003169 abnormal scala media morphology "any malformation or absence of the division of the spiral canal of the cochlea that contains the organ of Corti (the neuroepithelial receptor organ for hearing)" [J:23837, J:46972, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

 MP:0003202 abnormal neuron apoptosis "change in the timing or the number of neurons undergoing programmed cell death" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: C.Cg-Hey2tm1Mtc

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: C.Cg-Hey2tm1Mtc

Allelic Composition: Fgf8tm1.1Mrt/Fgf8tm1.4Mrt,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr,Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr,Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdyntm1Zim/Pdyntm1Zim
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003240 loss of hippocampal neurons "loss of neurons in the hippocampal region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003241 loss of cortex neurons "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003308 abnormal cochlear sensory epithelium 
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Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Fgf8tm1.2Mrt/Fgf8tm1.3Mrt,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003425 abnormal optic vesicle formation "anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0003648 abnormal radial glial cell morphology "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sema3atm1.1Tyag/Sema3atm1.1Tyag,Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

 MP:0003703 abnormal vestibulocochlear ganglion morphology "malformed group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

Allelic Composition: Chd7tm1.1Dmm/Chd7+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0003825 abnormal pillar cell morphology "abnormalities of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf8tm1.2Mrt/Fgf8tm1.3Mrt,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003938 abnormal ear development "developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

Allelic Composition: Chd7tm1.1Dmm/Chd7+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0004160 retroesophageal right subclavian artery "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0004236 absent masseter muscle "absence of the masticatory muscle of posterior cheek" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0004238 absent pterygoid muscle "absence of either the internal or external or of both pterygoid muscles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0004249 abnormal crista ampullaris morphology "anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [J:60193, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

Allelic Composition: Slc12a2tm1.1Jheb/Slc12a2tm1.1Jheb,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1Yizh/Cdc42tm1Yizh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+,Frs2tm1Fwan/Frs2tm1Fwan,Frs3tm1Jheb/Frs3tm1Jheb
Genetic Background: involves: 129 * Swiss Webster

 MP:0004276 abnormal medial ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the neocortex; however, hippocampal neurons, thalamus, septum and olfactory bulb neurons are also partly derived from the MGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Gli2tm2.1Alj/Gli2+,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster

Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+,Frs2tm1Fwan/Frs2tm1Fwan,Frs3tm1Jheb/Frs3tm1Jheb
Genetic Background: involves: 129 * Swiss Webster

Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Foxg1tm1(cre)Skm/Foxg1+,Fgfr1tm3.1Sor/Fgfr1tm1Jpa
Genetic Background: involves: 129

 MP:0004277 abnormal lateral ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1+,Tg(tetO-Gsx2,-EGFP)1Kcam/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+,Frs2tm1Fwan/Frs2tm1Fwan,Frs3tm1Jheb/Frs3tm1Jheb
Genetic Background: involves: 129 * Swiss Webster

Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Foxg1tm1(cre)Skm/Foxg1+,Fgfr1tm3.1Sor/Fgfr1tm1Jpa
Genetic Background: involves: 129

 MP:0004282 retrognathia "abnormal posterior positioning of one or both jaws, particularly the mandible, relative to the facial skeleton and soft tissues" [J:41682, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0004298 vestibular ganglion degeneration "loss of the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004301 absent supporting cells "absence of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0004310 small otic vesicle "reduced size of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0004311 otic vesicle hypoplasia "underdevelopment of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear, usually due to a reduction in cell number" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0004312 absent pillar cells "absence of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf8tm1.2Mrt/Fgf8tm1.3Mrt,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004314 absent vestibule "absence of the cavity between the semicircular canals and the cochlea of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0004315 absent saccule "absence of the smaller of the two sacs in the vestibule " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004325 absent vestibular hair cells "absence of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Jlew/Jag1tm1Jlew,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: C57BL/6J

 MP:0004329 saccular degeneration "degeneration or loss of the smaller of the two sacs in the vestibule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc12a2tm1.1Jheb/Slc12a2tm1.1Jheb,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004330 abnormal saccular macula morphology "any structural abnormalities in the oval neuroepithelial sensory receptor in the anterior wall of the saccule; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004332 utricular degeneration "degeneration or loss of the larger of the two sacs in the vestibule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc12a2tm1.1Jheb/Slc12a2tm1.1Jheb,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004333 abnormal utricular macula morphology "any structural abnormalities in the neuroepithelial sensory receptor in the inferolateral wall of the utricle; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies; normally sensitive to linear acceleration in the longitudinal axis of the body and to gravitational influences" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Jlew/Jag1tm1Jlew,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: C57BL/6J

Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0004336 small utricle "reduced size of the larger of the two sacs in the vestibule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0004369 absent utricle "absence of the larger of the two sacs in the vestibule" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004395 increased cochlear inner hair cell number "increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Jlew/Jag1tm1Jlew,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: C57BL/6J

Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Notch1tm1Grid/Notch1tm2Rko,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6J * Swiss Webster

 MP:0004399 abnormal cochlear outer hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0004401 increased cochlear outer hair cell number "increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004403 absent cochlear outer hair cells "absence of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Jlew/Jag1tm1Jlew,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: C57BL/6J

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0004405 absent cochlear hair cells "absence of the sensory epithelial cells of the cochlea; these cells are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0004406 abnormal cochlear hair cell number "abnormal number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0004408 decreased cochlear hair cell number "decreased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0004424 temporal bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the large, irregular bone located at the base and side of the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0004492 abnormal orientation of inner hair cell stereociliary bundles "misorientation or rotation of inner hair cell (IHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0004497 decreased supporting cell number "decreased number of the highly differentiated epithelial cells with distinctive morphological features which surround the hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Grid/Notch1tm2Rko,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6J * Swiss Webster

 MP:0004538 abnormal maxillary shelf "any structural anomaly of the outgrowth of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gaktm2Legr/Gaktm2Legr,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004555 pharynx hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells,of the passage between the mouth and the posterior nares and the larynx and esophagus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0004572 fusion of basioccipital and basisphenoid bone "union of the basioccipital and basisphenoid bones into one structure, when this fusion does not normally occur (such as in a species where these bones normally persist as separate entities)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0004589 abnormal cochlear hair cell development "atypical initial production, differentiation, migration or maturation of the sensory epithelial cells of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0004726 abnormal nasal capsule morphology "any structural abnormality in the cartilage around the developing nasal cavity of the embryo" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gaktm2Legr/Gaktm2Legr,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004900 absent zygomatic arch "absence of the bony arch that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0004922 abnormal common crus morphology "any structural abnormality in the united, nonampullary ends of the superior and posterior semicircular ducts of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxg1tm1M/Foxg1tm1M
Genetic Background: involves: 129S1/Sv

Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

Allelic Composition: Foxg1tm1Chzh/Foxg1tm1Chzh,Tg(Fzd9-cre/ERT)1Chzh/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0004979 abnormal neuronal precursor cell number "deviation from the normal count of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Rhoatm1Yuyo/Rhoatm1Yuyo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
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Allelic Composition: Cdc42tm1Yizh/Cdc42tm1Yizh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Six3tm3Gco/Six3tm3Gco,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005170 cleft lip "defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gaktm2Legr/Gaktm2Legr,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx2tm1Mlc/Pbx2tm1Mlc,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv

Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx3tm1Mlc/Pbx3+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Wnt9btm1Amc/Wnt9btm1Amc,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Pbx1tm1Mlc/Pbx1+,Wnt9btm1Amc/Wnt9btm1Amc,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129X1/SvJ

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptger4tm1.2Matb/Ptger4tm1.2Matb
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005361 small pituitary gland "reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0005545 abnormal lens development "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0005579 absent outer ear "missing auricles or external acoustic meatus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:17694]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0006007 abnormal basal ganglion morphology "malformation or absence of any of a group of nuclei associated with the ability to carry out willed movements, including the caudate, putamen, nucleus accumbens, globus pallidus, substantia nigra, and subthalamic nucleus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006011 abnormal endolymphatic duct morphology "any structural alteration in the small membranous canal, connecting with both saccule and utricle of the membranous labyrinth, passing through the aqueduct of vestibule, and terminating in the endolymphatic sac." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0006024 collapsed Reissner membrane "the Reissner s membrane, which normally separates the scala media from the scala vestibuli, has collapsed onto the spiral limbus and the tectorial membrane of the organ of Corti" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:37461:]
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Allelic Composition: Bsndtm1Tjj/Bsndtm1Tjj,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Slc12a2tm1.1Jheb/Slc12a2tm1.1Jheb,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006031 abnormal branchial pouch morphology "malfomation or anomaly in the series of grooves that form between the branchial arches; these endodermal evaginations develop into epithelial tissues and organs" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptger4tm1.2Matb/Ptger4tm1.2Matb
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr,Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0006039 decreased mitochondrial proliferation "less than normal reproduction of mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx2tm1Mlc/Pbx2tm1Mlc,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0006089 abnormal saccule morphology "malformation in the smaller of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

 MP:0006090 abnormal utricle morphology "malformation in the larger of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0006149 blurred vision "loss of visiual acuity or ability to distinguish small details" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nbeal2gps/Nbeal2gps
Genetic Background: 129S1/SvImJ-Nbeal2gps

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: B6.129P2-Foxg1tm1(cre)Skm

 MP:0006285 absent inner ear "absence of all components of the labyrinth, including the semicircular canals, vestibule and cochlea" [J:86619, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0006286 inner ear hypoplasia "underdevelopment or reduced size of inner ear structures, usually due to decreased cell number" [J:83662, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0006289 otic capsule hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the cartilage or bony capsule surrounding the inner ear mechanism" [J:100584, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0006292 abnormal olfactory placode morphology "any structural abnormality in the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes" [J:62024, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0006331 abnormal patterning of the organ of Corti "anomaly in the organization of the various cell types within the organ of Corti into a set number of distinct rows" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf8tm1.2Mrt/Fgf8tm1.3Mrt,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008066 small endolymphatic duct "reduced size of the small membranous canal which connects with both saccule and utricle of the membranous labyrinth, passes through the aqueduct of vestibule, and terminates in the endolymphatic sac" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0008128 abnormal brain internal capsule morphology "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpamtm1.1Dali/Gpamtm1.1Dali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008227 absent anterior commissure "absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gpamtm1.1Dali/Gpamtm1.1Dali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008284 abnormal hippocampus pyramidal cell layer 
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Allelic Composition: Top2btm2Jcw/Top2btm2.1Jcw,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

 MP:0008285 abnormal hippocampus granule cell layer 
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Allelic Composition: Top2btm2Jcw/Top2btm2.1Jcw,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008441 thin cortical plate "reduced thickness of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+,Frs2tm1Fwan/Frs2tm1Fwan,Frs3tm1Jheb/Frs3tm1Jheb
Genetic Background: involves: 129 * Swiss Webster

 MP:0008488 abnormal semicircular canal ampulla morphology "any structural anomaly of the spherical enlargement at the base of each semicircular canal where they connect with the utricle, containing the crista ampullaris which detects movement of the fluid within the canals" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

Allelic Composition: Lmo4tm1Gan/Lmo4tm2.1Gan,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lmo4tm2.1Gan/Lmo4tm2.1Gan,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: B6.129P2-Foxg1tm1(cre)Skm

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
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Allelic Composition: Foxg1tm1M/Foxg1tm1M
Genetic Background: involves: 129S1/Sv

 MP:0008789 abnormal olfactory epithelium morphology "any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009690 abnormal neural tube mantle layer morphology "any structural anomaly of the layer of glia and differentiating neurons that will form the gray matter of the spinal cord; this lies between the ventricular and marginal layers and includes the basal and alar plates" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Foxg1tm1M/Foxg1tm1M
Genetic Background: involves: 129S1/Sv

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0009899 hyoid bone hypoplasia "underdevelopment of the hyoid bone, usually due to a deficiency in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0009901 abnormal frontonasal prominence morphology "any structural anomaly of an unpaired facial process in the embryo formed from the tissues surrounding the forebrain vesicle that develops into the forehead and bridge of the nose/snout" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Foxg1tm1M/Foxg1tm1M
Genetic Background: involves: 129S1/Sv

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nbeal2gps/Nbeal2gps
Genetic Background: 129S1/SvImJ-Nbeal2gps

 MP:0009971 decreased hippocampus pyramidal cell number "decreased number of the projection neurons in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009974 decreased cerebral cortex pyramidal cell number "reduced number of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: B6.129P2-Foxg1tm1(cre)Skm

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0010748 abnormal visual evoked potential "anomaly in the electroencephalographic pattern recorded from the occipital area generated in response to retinal stimulation such as flashing lights or inverting a contrasting image; may be used to evaluate optic nerve damage or visual perception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nbeal2gps/Nbeal2gps
Genetic Background: 129S1/SvImJ-Nbeal2gps

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Bsndtm1Tjj/Bsndtm1Tjj,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Top2btm2Jcw/Top2btm2.1Jcw,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx2tm1Mlc/Pbx2+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv

Allelic Composition: Mafbtm1.1Good/Mafbtm1Jeng,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Hexatm1Cota/Hexatm1Cota
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

Allelic Composition: Fgf8tm1.2Mrt/Fgf8tm1.3Mrt,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Bmp4tm3Blh/Bmp4tm3Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cdc42tm1Yizh/Cdc42tm1Yizh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Bmp4tm3Blh/Bmp4tm3Blh
Genetic Background: involves: 129S6/SvEvTac

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0012468 decreased striatum area "reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343, MGI:csmith]
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Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: B6.129P2-Foxg1tm1(cre)Skm

 MP:0012556 increased cell death "increased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+,Frs2tm1Fwan/Frs2tm1Fwan,Frs3tm1Jheb/Frs3tm1Jheb
Genetic Background: involves: 129 * Swiss Webster

 MP:0012559 decreased forebrain volume "decrease from the average range of forebrain volume compared to normal" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: B6.129P2-Foxg1tm1(cre)Skm

 MP:0012683 absent telencephalon "absence of the enlarged anteriolateral part of the brain; consists of the paired cerebral hemispheres and olfactory bulbs, the basal ganglia and the connecting structures" [MGI:anna]
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Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+,Frs2tm1Fwan/Frs2tm1Fwan,Frs3tm1Jheb/Frs3tm1Jheb
Genetic Background: involves: 129 * Swiss Webster

Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd,Foxg1tm1(cre)Skm/Foxg1+,Fgfr1tm3.1Sor/Fgfr1tm1Jpa
Genetic Background: involves: 129

 MP:0013820 absent optic cup "absence of the double walled structure formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and neuronal layers of the retina, with the mouth of the optic cup developing into the pupil of the eye" [MGI:smb]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0020083 decreased hippocampus volume "decrease from the average range of the hippocampus volume compared to normal" [GOC:NV]
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Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: B6.129P2-Foxg1tm1(cre)Skm

 MP:0020527 small thalamus "decreased size of the thalamus" [MGI:smb]
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Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: B6.129P2-Foxg1tm1(cre)Skm

 MP:0030228 absent tubotympanic recess "absence of the elongate recess derived from the first pharyngeal pouch; its distal part contributes to the formation of the tympanic membrane, its proximal part elongates to form the auditory tube, and its cavity gives rise to the tympanic cavity and mastoid antrum" [http://medicine.academic.ru/156417/tubotympanic_recess, MGI:anna]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0030250 frontonasal prominence hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the unpaired embryonic process that is formed from the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout" [MGI:anna]
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Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+,Frs2tm1Fwan/Frs2tm1Fwan,Frs3tm1Jheb/Frs3tm1Jheb
Genetic Background: involves: 129 * Swiss Webster

Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Foxg1tm1(cre)Skm/Foxg1+,Fgfr1tm1Jpa/Fgfr1tm1Jpa
Genetic Background: involves: 129

Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Foxg1tm1(cre)Skm/Foxg1+,Fgfr1tm3.1Sor/Fgfr1tm1Jpa
Genetic Background: involves: 129

 MP:0030313 abnormal face development "any anomaly in the process in which the anatomical structures of the face are generated and organized" [GO:0060325]
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Allelic Composition: Bmp4tm3Blh/Bmp4tm3Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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