ENSMUSG00000030067


Mus musculus

Features
Gene ID: ENSMUSG00000030067
  
Biological name :Foxp1
  
Synonyms : Foxp1 / Mus musculus forkhead box P1 (Foxp1), transcript variant 4, mRNA. / P58462
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D3
Gene start: 98925338
Gene end: 99522721
  
Corresponding Affymetrix probe sets: 10546661 (MoGene1.0st)   1421140_a_at (Mouse Genome 430 2.0 Array)   1421141_a_at (Mouse Genome 430 2.0 Array)   1421142_s_at (Mouse Genome 430 2.0 Array)   1435221_at (Mouse Genome 430 2.0 Array)   1435222_at (Mouse Genome 430 2.0 Array)   1438802_at (Mouse Genome 430 2.0 Array)   1443258_at (Mouse Genome 430 2.0 Array)   1455242_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135181
Ensembl peptide - ENSMUSP00000135098
Ensembl peptide - ENSMUSP00000135187
Ensembl peptide - ENSMUSP00000135809
Ensembl peptide - ENSMUSP00000135764
Ensembl peptide - ENSMUSP00000135635
Ensembl peptide - ENSMUSP00000135517
Ensembl peptide - ENSMUSP00000135237
Ensembl peptide - ENSMUSP00000135229
Ensembl peptide - ENSMUSP00000073953
Ensembl peptide - ENSMUSP00000108948
Ensembl peptide - ENSMUSP00000108950
Ensembl peptide - ENSMUSP00000108952
Ensembl peptide - ENSMUSP00000108954
Ensembl peptide - ENSMUSP00000108955
Ensembl peptide - ENSMUSP00000117550
Ensembl peptide - ENSMUSP00000120244
Ensembl peptide - ENSMUSP00000121404
Ensembl peptide - ENSMUSP00000134817
Ensembl peptide - ENSMUSP00000134869
Ensembl peptide - ENSMUSP00000135041
NCBI entrez gene - 108655     See in Manteia.
MGI - MGI:1914004
RefSeq - XM_017321306
RefSeq - NM_001347345
RefSeq - NM_053202
RefSeq - XM_006505308
RefSeq - XM_006505310
RefSeq - XM_006505311
RefSeq - XM_006505312
RefSeq - XM_006505313
RefSeq - XM_006505314
RefSeq - XM_006505315
RefSeq - XM_006505316
RefSeq - XM_006505317
RefSeq - XM_006505318
RefSeq - XM_006505319
RefSeq - XM_006505320
RefSeq - XM_006505321
RefSeq - XM_006505322
RefSeq - XM_006505323
RefSeq - XM_006505324
RefSeq - XM_017321301
RefSeq - XM_017321302
RefSeq - XM_017321303
RefSeq - XM_017321304
RefSeq - XM_017321305
RefSeq - NM_001197321
RefSeq - NM_001197322
RefSeq Peptide - NP_001334274
RefSeq Peptide - NP_444432
RefSeq Peptide - NP_001184250
RefSeq Peptide - NP_001184251
swissprot - D3Z2T4
swissprot - D3Z0J5
swissprot - H3BJ24
swissprot - H3BJ68
swissprot - H3BJM1
swissprot - H3BJR8
swissprot - H3BJZ5
swissprot - E2S038
swissprot - H3BK38
swissprot - H3BKT4
swissprot - H3BL33
swissprot - H3BLF2
swissprot - A0A0R4J282
swissprot - P58462
swissprot - A0A0R4J1H9
swissprot - H3BK30
swissprot - D3Z6Q4
swissprot - D3Z6Q3
swissprot - D3Z454
Ensembl - ENSMUSG00000030067
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxp1bENSDARG00000014181Danio rerio
 FOXP1ENSGALG00000007769Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxp2 / P58463 / Forkhead box protein P2 / O15409* / forkhead box P2*ENSMUSG0000002956364
Foxp4 / Q9DBY0 / Forkhead box protein P4 / Q8IVH2* / forkhead box P4*ENSMUSG0000002399156
Foxp3 / Q99JB6 / Forkhead box protein P3 Forkhead box protein P3, C-terminally processed Forkhead box protein P3 41 kDa form / Q9BZS1* / forkhead box P3*ENSMUSG0000003952123
Foxd2 / O35392 / Forkhead box protein D2 / O60548* / forkhead box D2*ENSMUSG0000005521011
Foxd3 / forkhead box D3 / Q9UJU5*ENSMUSG0000006726110
Foxg1 / Q60987 / Forkhead box protein G1 / P55316* / forkhead box G1*ENSMUSG0000002095010
Foxd1 / Q61345 / Forkhead box protein D1 / Q16676* / forkhead box D1*ENSMUSG0000007830210
Foxf2 / O54743 / Forkhead box protein F2 / Q12947* / forkhead box F2*ENSMUSG000000384029
Foxq1 / O70220 / Forkhead box protein Q1 / Q9C009* / forkhead box Q1*ENSMUSG000000384159
Foxf1 / Q61080 / Forkhead box protein F1 / Q12946* / forkhead box F1*ENSMUSG000000428129
Foxd4 / Q60688 / Forkhead box protein D4 / Q9NU39* / Q12950* / Q3SYB3* / Q5VV16* / Q6VB84* / Q8WXT5* / FOXD4L3* / FOXD4L4* / FOXD4L5* / FOXD4L6* / FOXD4L1* / forkhead box D4* / forkhead bo...ENSMUSG000000514909
Foxe1 / Q8R2I0 / Forkhead box protein E1 / O00358* / forkhead box E1*ENSMUSG000000709909
Foxe3 / Q9QY14 / Forkhead box protein E3 / Q13461* / forkhead box E3*ENSMUSG000000445188
Foxh1 / O88621 / Forkhead box protein H1 / O75593* / forkhead box H1*ENSMUSG000000338377
Gm5294 / AC187653.1*ENSMUSG000000945047
Gm43517ENSMUSG000000899223


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR030456  Fork head domain conserved site 2
 IPR032354  FOXP, coiled-coil domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IGI
 biological_processGO:0002329 pre-B cell differentiation IMP
 biological_processGO:0002639 positive regulation of immunoglobulin production IMP
 biological_processGO:0002903 negative regulation of B cell apoptotic process ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007519 skeletal muscle tissue development IGI
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0010595 positive regulation of endothelial cell migration ISS
 biological_processGO:0021517 ventral spinal cord development IEP
 biological_processGO:0021756 striatum development IEA
 biological_processGO:0030316 osteoclast differentiation ISS
 biological_processGO:0030324 lung development IGI
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0032496 response to lipopolysaccharide ISS
 biological_processGO:0032680 regulation of tumor necrosis factor production ISS
 biological_processGO:0033152 immunoglobulin V(D)J recombination IMP
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0035926 chemokine (C-C motif) ligand 2 secretion ISS
 biological_processGO:0036035 osteoclast development ISS
 biological_processGO:0042116 macrophage activation ISS
 biological_processGO:0042117 monocyte activation ISS
 biological_processGO:0042118 endothelial cell activation ISS
 biological_processGO:0045214 sarcomere organization IGI
 biological_processGO:0045655 regulation of monocyte differentiation ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation ISS
 biological_processGO:0048745 smooth muscle tissue development IGI
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IGI
 biological_processGO:0055007 cardiac muscle cell differentiation IMP
 biological_processGO:0060043 regulation of cardiac muscle cell proliferation IMP
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway ISS
 biological_processGO:0061052 negative regulation of cell growth involved in cardiac muscle cell development IEA
 biological_processGO:0061140 lung secretory cell differentiation IGI
 biological_processGO:0061470 T follicular helper cell differentiation IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0072358 cardiovascular system development IMP
 biological_processGO:0072619 interleukin-21 secretion IDA
 biological_processGO:1900424 regulation of defense response to bacterium ISS
 biological_processGO:1901249 regulation of lung goblet cell differentiation IGI
 biological_processGO:1901250 negative regulation of lung goblet cell differentiation IGI
 biological_processGO:1901256 regulation of macrophage colony-stimulating factor production ISS
 biological_processGO:1904637 cellular response to ionomycin IEA
 biological_processGO:1905206 positive regulation of hydrogen peroxide-induced cell death IEA
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IGI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0043621 protein self-association ISS
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Grxcr1pi-2J/Grxcr1pi-2J
Genetic Background: DBA/2J-Grxcr1pi-2J/J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Tmem107schlei/Tmem107tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C3HeB/FeJ * C57BL/6J * C57BL/6N

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxp1tm1.1Pwt/Foxp1tm1.1Pwt,Foxp4tm2.1Eem/Foxp4tm2.1Eem,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cybbtm1Din/Cybbtm1Din
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003115 abnormal respiratory system development "aberrant differentiation of pulmonary tissues" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tmem107schlei/Tmem107tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C3HeB/FeJ * C57BL/6J * C57BL/6N

Allelic Composition: Foxp1tm1.1Pwt/Foxp1tm1.1Pwt,Foxp4tm2.1Eem/Foxp4tm2.1Eem,Scgb1a1tm1(icre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003159 abnormal esophageal smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue lining the esophagus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0003160 abnormal esophageal development "aberrant formation of the part of the digestive canal through which food passes from the pharynx to the stomach" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0003808 enlarged endocardial cushions "larger than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [mac:Megan A. Cassell, Mouse Genome Informatics Curator]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0004548 dilated esophagus "an expansion in the lumen volume of the part of the digestive canal through which food passes from the pharynx to the stomach" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxp1tm1.1Pwt/Foxp1tm1.1Pwt,Foxp4tm2.1Eem/Foxp4tm2.1Eem,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0005631 decreased lung weight "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grxcr1pi-2J/Grxcr1pi-2J
Genetic Background: DBA/2J-Grxcr1pi-2J/J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grxcr1pi-2J/Grxcr1pi-2J
Genetic Background: DBA/2J-Grxcr1pi-2J/J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grxcr1pi-2J/Grxcr1pi-2J
Genetic Background: DBA/2J-Grxcr1pi-2J/J

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

Allelic Composition: Foxp1Gt(S17-4A1)Sor/Foxp1+,Ncor2tm1Rsd/Ncor2+
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor

Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0010556 thin ventricle myocardium compact layer "reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0010588 conotruncal ridge hyperplasia "overdevelopment or increased size of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0010856 dilated respiratory conducting tubes "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0010949 decreased Clara cell number "reduced number of the rounded, club-shaped, nonciliated cells found between ciliated cells in bronchiolar epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tmem107schlei/Tmem107tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C3HeB/FeJ * C57BL/6J * C57BL/6N

 MP:0011024 abnormal branching involved in lung morphogenesis "anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Foxp1tm1.1Pwt/Foxp1tm1.1Pwt,Foxp4tm2.1Eem/Foxp4tm2.1Eem,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Foxp1Gt(S17-4A1)Sor/Foxp1+,Ncor2tm1Rsd/Ncor2+
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0011148 decreased mesenchymal cell proliferation involved in lung development "reduction in the expansion rate of a lung mesenchymal cell population by cell division" [MGI:anna]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0011394 increased fetal cardiomyocyte proliferation "increase in the ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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