ENSMUSG00000070990


Mus musculus

Features
Gene ID: ENSMUSG00000070990
  
Biological name :Foxe1
  
Synonyms : Forkhead box protein E1 / Foxe1 / Q8R2I0
  
Possible biological names infered from orthology : forkhead box E1 / O00358
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: B1
Gene start: 46343609
Gene end: 46346412
  
Corresponding Affymetrix probe sets: 10504728 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000092715
NCBI entrez gene - 110805     See in Manteia.
MGI - MGI:1353500
RefSeq - NM_183298
RefSeq Peptide - NP_899121
swissprot - Q8R2I0
Ensembl - ENSMUSG00000070990
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxe1ENSDARG00000079266Danio rerio
 foxe3ENSDARG00000062892Danio rerio
 FOXE1ENSGALG00000026252Gallus gallus
 FOXE1ENSG00000178919Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxe3 / Q9QY14 / Forkhead box protein E3 / Q13461* / forkhead box E3*ENSMUSG0000004451837
Foxd2 / O35392 / Forkhead box protein D2 / O60548* / forkhead box D2*ENSMUSG0000005521033
Foxd1 / Q61345 / Forkhead box protein D1 / Q16676* / forkhead box D1*ENSMUSG0000007830229
Foxd3 / forkhead box D3 / Q9UJU5*ENSMUSG0000006726128
Foxd4 / Q60688 / Forkhead box protein D4 / Q9NU39* / Q12950* / Q3SYB3* / Q5VV16* / Q6VB84* / Q8WXT5* / FOXD4L3* / FOXD4L4* / FOXD4L5* / FOXD4L6* / FOXD4L1* / forkhead box D4* / forkhead bo...ENSMUSG0000005149028
Foxf2 / O54743 / Forkhead box protein F2 / Q12947* / forkhead box F2*ENSMUSG0000003840226
Foxg1 / Q60987 / Forkhead box protein G1 / P55316* / forkhead box G1*ENSMUSG0000002095025
Foxq1 / O70220 / Forkhead box protein Q1 / Q9C009* / forkhead box Q1*ENSMUSG0000003841523
Gm5294 / AC187653.1*ENSMUSG0000009450421
Foxf1 / Q61080 / Forkhead box protein F1 / Q12946* / forkhead box F1*ENSMUSG0000004281221
Foxh1 / O88621 / Forkhead box protein H1 / O75593* / forkhead box H1*ENSMUSG0000003383719
Foxp1 / P58462 / Mus musculus forkhead box P1 (Foxp1), transcript variant 4, mRNA.ENSMUSG0000003006717
Foxp4 / Q9DBY0 / Forkhead box protein P4 / Q8IVH2* / forkhead box P4*ENSMUSG0000002399117
Foxp2 / P58463 / Forkhead box protein P2 / O15409* / forkhead box P2*ENSMUSG0000002956314
Gm43517ENSMUSG0000008992212
Foxp3 / Q99JB6 / Forkhead box protein P3 Forkhead box protein P3, C-terminally processed Forkhead box protein P3 41 kDa form / Q9BZS1* / forkhead box P3*ENSMUSG0000003952112


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006590 thyroid hormone generation IMP
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0031069 hair follicle morphogenesis IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048562 embryonic organ morphogenesis IMP
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060022 hard palate development IEA
 biological_processGO:0060023 soft palate development IEA
 biological_processGO:0060465 pharynx development IEA
 biological_processGO:1904888 cranial skeletal system development IMP
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0043565 sequence-specific DNA binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Hps3coa/Hps3coa,Myo5ad/Myo5ad,Mregdsu/Mregdsu
Genetic Background: involves: C57BL/10J

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
Show

Allelic Composition: Hps3coa/Hps3coa,Myo5ad/Myo5ad,Mregdsu/Mregdsu
Genetic Background: involves: C57BL/10J

 MP:0000396 increased curvature of hairs "distinct C- or S- shaped curvature of the hairs" [J:4606]
Show

Allelic Composition: Hps3coa/Hps3coa,Myo5ad/Myo5ad,Mregdsu/Mregdsu
Genetic Background: involves: C57BL/10J

 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
Show

Allelic Composition: Hps3coa/Hps3coa,Myo5ad/Myo5ad,Mregdsu/Mregdsu
Genetic Background: involves: C57BL/10J

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Hps3coa/Hps3coa,Myo5ad/Myo5ad,Mregdsu/Mregdsu
Genetic Background: involves: C57BL/10J

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hps3coa/Hps3coa,Myo5ad/Myo5ad,Mregdsu/Mregdsu
Genetic Background: involves: C57BL/10J

 MP:0003351 decreased circulating levels of thyroid hormone "reduced concentration of hormones in the blood that are synthesized and secreted by the thyroid" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Hps3coa/Hps3coa,Myo5ad/Myo5ad,Mregdsu/Mregdsu
Genetic Background: involves: C57BL/10J

 MP:0003421 abnormal thyroid gland development "failure or abnormality in the formation of the thyroid gland during organogenesis" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95017]
Show

Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: B6.129P2-Hhextm1Rbe

Allelic Composition: Foxe1tm1Rdl/Foxe1tm1Rdl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxe1tm1Rdl/Foxe1tm1Rdl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005122 increased circulating thyroid-stimulating hormone level "greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hps3coa/Hps3coa,Myo5ad/Myo5ad,Mregdsu/Mregdsu
Genetic Background: involves: C57BL/10J

 MP:0005314 absent thyroid gland " missing endocrine gland that is normally located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30559]
Show

Allelic Composition: Hps3coa/Hps3coa,Myo5ad/Myo5ad,Mregdsu/Mregdsu
Genetic Background: involves: C57BL/10J

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
Show

Allelic Composition: Foxe1tm1Rdl/Foxe1tm1Rdl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Foxe1tm1Rdl/Foxe1tm1Rdl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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