ENSMUSG00000029563


Mus musculus

Features
Gene ID: ENSMUSG00000029563
  
Biological name :Foxp2
  
Synonyms : Forkhead box protein P2 / Foxp2 / P58463
  
Possible biological names infered from orthology : forkhead box P2 / O15409
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A1
Gene start: 14901349
Gene end: 15441977
  
Corresponding Affymetrix probe sets: 10536444 (MoGene1.0st)   1422014_at (Mouse Genome 430 2.0 Array)   1438231_at (Mouse Genome 430 2.0 Array)   1438232_at (Mouse Genome 430 2.0 Array)   1440108_at (Mouse Genome 430 2.0 Array)   1441365_at (Mouse Genome 430 2.0 Array)   1458191_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000111134
Ensembl peptide - ENSMUSP00000123067
Ensembl peptide - ENSMUSP00000123007
Ensembl peptide - ENSMUSP00000121503
Ensembl peptide - ENSMUSP00000116650
Ensembl peptide - ENSMUSP00000116017
Ensembl peptide - ENSMUSP00000111137
Ensembl peptide - ENSMUSP00000111135
Ensembl peptide - ENSMUSP00000031545
Ensembl peptide - ENSMUSP00000111129
Ensembl peptide - ENSMUSP00000111130
Ensembl peptide - ENSMUSP00000111132
NCBI entrez gene - 114142     See in Manteia.
MGI - MGI:2148705
RefSeq - XM_017321341
RefSeq - NM_001286607
RefSeq - NM_053242
RefSeq - NM_212435
RefSeq Peptide - NP_001273536
RefSeq Peptide - NP_444472
RefSeq Peptide - NP_997600
swissprot - D3Z4F4
swissprot - P58463
swissprot - Q3TPK1
swissprot - D3Z7E9
swissprot - D3Z2Q6
swissprot - D3Z146
swissprot - D3YUQ7
swissprot - D3Z142
swissprot - D3YUM2
swissprot - F6UMM1
Ensembl - ENSMUSG00000029563
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FOXP2ENSGALG00000009424Gallus gallus
 FOXP2ENSG00000128573Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxp1 / P58462 / Mus musculus forkhead box P1 (Foxp1), transcript variant 4, mRNA.ENSMUSG0000003006763
Foxp4 / Q9DBY0 / Forkhead box protein P4 / Q8IVH2* / forkhead box P4*ENSMUSG0000002399159
Foxp3 / Q99JB6 / Forkhead box protein P3 Forkhead box protein P3, C-terminally processed Forkhead box protein P3 41 kDa form / Q9BZS1* / forkhead box P3*ENSMUSG0000003952123
Foxd2 / O35392 / Forkhead box protein D2 / O60548* / forkhead box D2*ENSMUSG0000005521011
Foxg1 / Q60987 / Forkhead box protein G1 / P55316* / forkhead box G1*ENSMUSG0000002095010
Foxd3 / forkhead box D3 / Q9UJU5*ENSMUSG0000006726110
Foxd1 / Q61345 / Forkhead box protein D1 / Q16676* / forkhead box D1*ENSMUSG0000007830210
Foxf2 / O54743 / Forkhead box protein F2 / Q12947* / forkhead box F2*ENSMUSG000000384029
Foxd4 / Q60688 / Forkhead box protein D4 / Q9NU39* / Q12950* / Q3SYB3* / Q5VV16* / Q6VB84* / Q8WXT5* / FOXD4L3* / FOXD4L4* / FOXD4L5* / FOXD4L6* / FOXD4L1* / forkhead box D4* / forkhead bo...ENSMUSG000000514908
Foxe3 / Q9QY14 / Forkhead box protein E3 / Q13461* / forkhead box E3*ENSMUSG000000445188
Foxq1 / O70220 / Forkhead box protein Q1 / Q9C009* / forkhead box Q1*ENSMUSG000000384158
Gm5294 / AC187653.1*ENSMUSG000000945047
Foxe1 / Q8R2I0 / Forkhead box protein E1 / O00358* / forkhead box E1*ENSMUSG000000709907
Foxh1 / O88621 / Forkhead box protein H1 / O75593* / forkhead box H1*ENSMUSG000000338377
Foxf1 / Q61080 / Forkhead box protein F1 / Q12946* / forkhead box F1*ENSMUSG000000428127
Gm43517ENSMUSG000000899224


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR030456  Fork head domain conserved site 2
 IPR032354  FOXP, coiled-coil domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007519 skeletal muscle tissue development IGI
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0021549 cerebellum development IMP
 biological_processGO:0021757 caudate nucleus development IEA
 biological_processGO:0021758 putamen development IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030324 lung development IGI
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0040007 growth IMP
 biological_processGO:0042297 vocal learning IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0048745 smooth muscle tissue development IGI
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IGI
 biological_processGO:0060013 righting reflex IMP
 biological_processGO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis IGI
 biological_processGO:0098582 innate vocalization behavior IEA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0050681 androgen receptor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000054 delayed ear emergence "late onset of the growth of the outer ear" [J:49421]
Show

Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Foxp2tm1Momo/Foxp2tm1Momo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Foxp2tm1Momo/Foxp2tm1Momo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Foxp2tm1Sfis/Foxp2tm1.2Sfis,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Foxp2tm1Momo/Foxp2tm1Momo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Foxp2N549K/Foxp2N549K
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Foxp2R552H/Foxp2R552H
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Foxp2S321X/Foxp2S321X
Genetic Background: involves: C3HeB/FeJ

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: Foxp2tm1Momo/Foxp2tm1Momo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Foxp2N549K/Foxp2N549K
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

Allelic Composition: Foxp2tm1Bux/Foxp2+
Genetic Background: involves: C57BL/6

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

Allelic Composition: Foxp2tm1Momo/Foxp2tm1Momo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Hoxa5tm1.2Ljea/Hoxa5tm1.2Ljea
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

Allelic Composition: Foxp2tm1Momo/Foxp2tm1Momo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Foxp2tm1Momo/Foxp2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Lpltm1Bres/Lpl+
Genetic Background: involves: 129S4/SvJae

 MP:0001290 delayed eyelid opening "late average time for the first postnatal eye opening" [J:17792]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

Allelic Composition: Foxp2tm1Sfis/Foxp2tm1.2Sfis,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

Allelic Composition: Foxp2tm1Woen/Foxp2tm1Woen
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxp2tm2.1Woen/Foxp2tm2.1Woen
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Foxp2tm1Woen/Foxp2tm1Woen
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Foxp2tm2.1Woen/Foxp2tm2.1Woen
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

Allelic Composition: Foxp2tm2.2Woen/Foxp2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Foxp2tm2.1Woen/Foxp2tm2.1Woen
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Foxp2R552H/Foxp2R552H
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Foxp2tm2.2Woen/Foxp2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

Allelic Composition: Foxp2tm1Sfis/Foxp2tm1.2Sfis,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Foxp2tm1Momo/Foxp2tm1Momo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
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Allelic Composition: Foxp2tm1Momo/Foxp2tm1Momo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Foxp2R552H/Foxp2R552H
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxp2tm2.1Woen/Foxp2tm2.1Woen
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

Allelic Composition: Foxp2tm1Bux/Foxp2+
Genetic Background: involves: C57BL/6

Allelic Composition: Foxp2tm1Momo/Foxp2tm1Momo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Foxp2tm2.1Woen/Foxp2tm2.1Woen
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxp2tm2.2Woen/Foxp2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lpltm1Bres/Lpl+
Genetic Background: involves: 129S4/SvJae

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(RARA*)Soc/Gt(ROSA)26Sortm1(RARA*)Soc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Foxp2R552H/Foxp2R552H
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Foxp2S321X/Foxp2S321X
Genetic Background: involves: C3HeB/FeJ

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Foxp2R552H/Foxp2R552H
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0002862 altered righting response "altered ability or changed amount of time needed to recover from supine position" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Foxp2N549K/Foxp2N549K
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Foxp2R552H/Foxp2R552H
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Foxp2S321X/Foxp2S321X
Genetic Background: involves: C3HeB/FeJ

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Foxp2R552H/Foxp2R552H
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0003159 abnormal esophageal smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue lining the esophagus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0003160 abnormal esophageal development "aberrant formation of the part of the digestive canal through which food passes from the pharynx to the stomach" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Foxp2tm2.2Woen/Foxp2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0003648 abnormal radial glial cell morphology "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

Allelic Composition: Foxp2tm1Bux/Foxp2+
Genetic Background: involves: C57BL/6

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Foxp2tm2.2Woen/Foxp2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0004391 abnormal respiratory conducting tube "any structural anomaly of the tubes of the respiratory system that allows passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0004548 dilated esophagus "an expansion in the lumen volume of the part of the digestive canal through which food passes from the pharynx to the stomach" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp2tm2.1Woen/Foxp2tm2.1Woen
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Foxp2tm1Momo/Foxp2tm1Momo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxp2tm2.2Woen/Foxp2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0005356 positive geotaxis "mice, when placed on a downward on a slanting grid, walk down without turning around, or exhibit a delay in turning around, whereas wild type mice will always turn around and walk upward" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:79604]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

 MP:0005448 abnormal energy balance "aberrant intake or expenditure of calories as compared to the normal state" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxp2tm2.2Woen/Foxp2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0005573 increased breathing frequency "greater than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
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Allelic Composition: Foxp2tm2.2Woen/Foxp2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0005631 decreased lung weight "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Foxp2tm2.1Woen/Foxp2tm2.1Woen
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0006357 abnormal circulating mineral level "anomalous concentration in the blood of any naturally occurring, homogeneous inorganic solid substance having a definite chemical composition and highly ordered atomic arrangement that is required for growth and survival" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp2tm2.2Woen/Foxp2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp2tm2.2Woen/Foxp2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp2tm2.2Woen/Foxp2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp2tm2.1Woen/Foxp2tm2.1Woen
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
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Allelic Composition: Foxp2tm2.1Woen/Foxp2tm2.1Woen
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp2N549K/Foxp2N549K
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Foxp2R552H/Foxp2R552H
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Foxp2S321X/Foxp2S321X
Genetic Background: involves: C3HeB/FeJ

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

Allelic Composition: Foxp2tm1Momo/Foxp2tm1Momo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp2tm2.2Woen/Foxp2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp2tm1Sfis/Foxp2tm1.2Sfis,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Foxp2R552H/Foxp2R552H
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Foxp2S321X/Foxp2S321X
Genetic Background: involves: C3HeB/FeJ

 MP:0010394 decreased QRS amplitude "reduction in the size (height or maximum displacement) of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction, suggesting ventricular excitation defects" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp2tm1Woen/Foxp2tm1Woen
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0010856 dilated respiratory conducting tubes "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0011024 abnormal branching involved in lung morphogenesis "anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Foxp2tm1Sfis/Foxp2tm1.2Sfis,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Foxp2tm1Momo/Foxp2tm1Momo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Foxp2tm1Momo/Foxp2tm1Momo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011148 decreased mesenchymal cell proliferation involved in lung development "reduction in the expansion rate of a lung mesenchymal cell population by cell division" [MGI:anna]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0011890 increased circulating ferritin level "elevated concentration in the blood of ferritin, a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion; some ferritin is also found in the blood and is measured in tests for overall iron levels, anemia and chronic diseases" [MGI:csmith]
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Allelic Composition: Foxp2tm2.2Woen/Foxp2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0020351 decreased vocalization "decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

Allelic Composition: Foxp2tm1Bux/Foxp2+
Genetic Background: involves: C57BL/6

Allelic Composition: Foxp2tm1Momo/Foxp2tm1Momo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Foxp2tm1Woen/Foxp2tm1Woen
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Foxp2tm2.1Woen/Foxp2tm2.1Woen
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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