ENSMUSG00000038415


Mus musculus

Features
Gene ID: ENSMUSG00000038415
  
Biological name :Foxq1
  
Synonyms : Forkhead box protein Q1 / Foxq1 / O70220
  
Possible biological names infered from orthology : forkhead box Q1 / Q9C009
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.2
Gene start: 31556134
Gene end: 31560976
  
Corresponding Affymetrix probe sets: 10404402 (MoGene1.0st)   1422735_at (Mouse Genome 430 2.0 Array)   1438558_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036952
NCBI entrez gene - 15220     See in Manteia.
MGI - MGI:1298228
RefSeq - NM_008239
RefSeq Peptide - NP_032265
swissprot - O70220
Ensembl - ENSMUSG00000038415
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxq1aENSDARG00000030896Danio rerio
 foxq1bENSDARG00000055395Danio rerio
 FOXQ1ENSG00000164379Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxd2 / O35392 / Forkhead box protein D2 / O60548* / forkhead box D2*ENSMUSG0000005521026
Foxd1 / Q61345 / Forkhead box protein D1 / Q16676* / forkhead box D1*ENSMUSG0000007830224
Foxd3 / forkhead box D3 / Q9UJU5*ENSMUSG0000006726124
Foxd4 / Q60688 / Forkhead box protein D4 / Q9NU39* / Q12950* / Q3SYB3* / Q5VV16* / Q6VB84* / Q8WXT5* / FOXD4L3* / FOXD4L4* / FOXD4L5* / FOXD4L6* / FOXD4L1* / forkhead box D4* / forkhead bo...ENSMUSG0000005149024
Foxe3 / Q9QY14 / Forkhead box protein E3 / Q13461* / forkhead box E3*ENSMUSG0000004451822
Foxe1 / Q8R2I0 / Forkhead box protein E1 / O00358* / forkhead box E1*ENSMUSG0000007099022
Foxf2 / O54743 / Forkhead box protein F2 / Q12947* / forkhead box F2*ENSMUSG0000003840222
Gm5294 / AC187653.1*ENSMUSG0000009450420
Foxg1 / Q60987 / Forkhead box protein G1 / P55316* / forkhead box G1*ENSMUSG0000002095019
Foxf1 / Q61080 / Forkhead box protein F1 / Q12946* / forkhead box F1*ENSMUSG0000004281219
Foxh1 / O88621 / Forkhead box protein H1 / O75593* / forkhead box H1*ENSMUSG0000003383717
Foxp1 / P58462 / Mus musculus forkhead box P1 (Foxp1), transcript variant 4, mRNA.ENSMUSG0000003006715
Foxp2 / P58463 / Forkhead box protein P2 / O15409* / forkhead box P2*ENSMUSG0000002956314
Foxp4 / Q9DBY0 / Forkhead box protein P4 / Q8IVH2* / forkhead box P4*ENSMUSG0000002399114
Foxp3 / Q99JB6 / Forkhead box protein P3 Forkhead box protein P3, C-terminally processed Forkhead box protein P3 41 kDa form / Q9BZS1* / forkhead box P3*ENSMUSG0000003952112
Gm43517ENSMUSG000000899228


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0031069 hair follicle morphogenesis IMP
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000087 absent mandible "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

Allelic Composition: M412b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M54b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hoxa10tm1Ipc/Hoxa10+
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: M1185b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Hoxa10tm1Ipc/Hoxa10+
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Hoxa10tm1Ipc/Hoxa10+
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0000286 abnormal mitral valve morphology "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Hoxa10tm1Ipc/Hoxa10+
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0000411 shiny fur "fur with a glossy or glistening appearance" [J:45065]
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

Allelic Composition: Foxq1sa/Foxq1sa
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Foxq1sa-e1/Foxq1sa-e1
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Foxq1tm1Wen/Foxq1tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

Allelic Composition: M412b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M54b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ergmld2/Erg+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

Allelic Composition: M412b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M54b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0000505 reduced digestive secretion "decrease in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Foxq1tm1Wen/Foxq1tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxa10tm1Ipc/Hoxa10+
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Golga3Tg(06MGMT)T604Kccri/Golga3Tg(06MGMT)T604Kccri
Genetic Background: involves: C3H * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Golga3Tg(06MGMT)T604Kccri/Golga3Tg(06MGMT)T604Kccri
Genetic Background: involves: C3H * C57BL/6

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxq1sa-e1/Foxq1sa-e1
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

Allelic Composition: M241b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M412b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M54b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M624b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: M412b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M54b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: M412b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Ergmld2/Erg+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: M369b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Golga3Tg(06MGMT)T604Kccri/Golga3Tg(06MGMT)T604Kccri
Genetic Background: involves: C3H * C57BL/6

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: M1645b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M54b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: M876b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: Foxq1sa/Foxq1+,Sox4M91Ark/Sox4+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Foxq1sa/Foxq1+,M1073b/Del(13)36H
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: M369b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Foxq1sa-e1/Foxq1sa-e1
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Golga3Tg(06MGMT)T604Kccri/Golga3Tg(06MGMT)T604Kccri
Genetic Background: involves: C3H * C57BL/6

 MP:0001862 interstitial pneumonia "disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Golga3Tg(06MGMT)T604Kccri/Golga3Tg(06MGMT)T604Kccri
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Foxq1sa/Foxq1sa,Lystbg/Lystbg
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10/Rl

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Foxq1sa-e1/Foxq1sa-e1
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002074 abnormal hair texture "irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxq1sa-e1/Foxq1sa-e1
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

Allelic Composition: M369b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M412b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M54b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M624b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M876b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Golga3Tg(06MGMT)T604Kccri/Golga3Tg(06MGMT)T604Kccri
Genetic Background: involves: C3H * C57BL/6

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

Allelic Composition: M412b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M624b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

Allelic Composition: M412b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M54b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0002102 abnormal ear morphology "structural or developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

Allelic Composition: M412b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M54b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0002406 increased susceptibility to infection "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Golga3Tg(06MGMT)T604Kccri/Golga3Tg(06MGMT)T604Kccri
Genetic Background: involves: C3H * C57BL/6

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

Allelic Composition: M412b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M54b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr,Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
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Allelic Composition: Foxq1sa/Foxq1+,Sox4M91Ark/Del(13)36H
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Foxq1sa/Foxq1+,Sox4M91Ark/Del(13)36H
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxq1tm1Wen/Foxq1tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Foxq1sa/Foxq1+,M1073b/Del(13)36H
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M412b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M54b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Foxq1sa/Foxq1sa
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Foxq1sa-e1/Foxq1sa-e1
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0003811 abnormal hair cortex "anomalies in the spindle shaped cells of the hair shaft that contains keratin fibrils and matrix" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Foxq1sa-e1/Foxq1sa-e1
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0003812 abnormal hair medulla "anomalies of hair medullary cell formation and arrangement of the innermost core of the hair shaft " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Foxq1sa-e1/Foxq1sa-e1
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxq1sa/Foxq1+,Sox4M91Ark/Del(13)36H
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Foxq1sa/Foxq1sa
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
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Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

Allelic Composition: Foxq1sa/Foxq1+,Sox4M91Ark/Del(13)36H
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: Foxq1sa/Foxq1+,M1073b/Del(13)36H
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M241b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M412b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M54b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M624b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0005163 cyclopia "a congenital defect in which the two orbits are united to form a single cavity containing one eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60303]
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Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: M876b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: M1185b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Foxq1sa/Foxq1+,Sox4M91Ark/Del(13)36H
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0010404 ostium primum atrial septal defect "interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxq1sa/Foxq1+,Sox4M91Ark/Del(13)36H
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Foxq1sa/Foxq1+,Sox4M91Ark/Del(13)36H
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: M1185b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M1616b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M1645b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: M241b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Foxq1tm1Wen/Foxq1tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

Allelic Composition: Foxq1tm1Wen/Foxq1tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Golga3Tg(06MGMT)T604Kccri/Golga3Tg(06MGMT)T604Kccri
Genetic Background: involves: C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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