ENSMUSG00000023991


Mus musculus

Features
Gene ID: ENSMUSG00000023991
  
Biological name :Foxp4
  
Synonyms : Forkhead box protein P4 / Foxp4 / Q9DBY0
  
Possible biological names infered from orthology : forkhead box P4 / Q8IVH2
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 47867133
Gene end: 47924645
  
Corresponding Affymetrix probe sets: 10451613 (MoGene1.0st)   1429719_at (Mouse Genome 430 2.0 Array)   1431088_at (Mouse Genome 430 2.0 Array)   1431437_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108888
Ensembl peptide - ENSMUSP00000108890
Ensembl peptide - ENSMUSP00000094916
Ensembl peptide - ENSMUSP00000108887
NCBI entrez gene - 74123     See in Manteia.
MGI - MGI:1921373
RefSeq - XM_017317688
RefSeq - NM_001110824
RefSeq - NM_001110825
RefSeq - NM_028767
RefSeq - XM_017317686
RefSeq - XM_017317687
RefSeq Peptide - NP_083043
RefSeq Peptide - NP_001104295
RefSeq Peptide - NP_001104294
swissprot - A0A0R4J161
swissprot - A0A0R4J1I5
swissprot - D3Z726
swissprot - Q9DBY0
Ensembl - ENSMUSG00000023991
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FOXP4ENSGALG00000033497Gallus gallus
 FOXP4ENSG00000137166Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxp2 / P58463 / Forkhead box protein P2 / O15409* / forkhead box P2*ENSMUSG0000002956361
Foxp1 / P58462 / Mus musculus forkhead box P1 (Foxp1), transcript variant 4, mRNA.ENSMUSG0000003006758
Foxp3 / Q99JB6 / Forkhead box protein P3 Forkhead box protein P3, C-terminally processed Forkhead box protein P3 41 kDa form / Q9BZS1* / forkhead box P3*ENSMUSG0000003952124
Foxd2 / O35392 / Forkhead box protein D2 / O60548* / forkhead box D2*ENSMUSG0000005521011
Foxg1 / Q60987 / Forkhead box protein G1 / P55316* / forkhead box G1*ENSMUSG0000002095010
Foxf2 / O54743 / Forkhead box protein F2 / Q12947* / forkhead box F2*ENSMUSG0000003840210
Foxd3 / forkhead box D3 / Q9UJU5*ENSMUSG0000006726110
Foxd1 / Q61345 / Forkhead box protein D1 / Q16676* / forkhead box D1*ENSMUSG000000783029
Foxe1 / Q8R2I0 / Forkhead box protein E1 / O00358* / forkhead box E1*ENSMUSG000000709909
Foxe3 / Q9QY14 / Forkhead box protein E3 / Q13461* / forkhead box E3*ENSMUSG000000445189
Foxf1 / Q61080 / Forkhead box protein F1 / Q12946* / forkhead box F1*ENSMUSG000000428128
Foxq1 / O70220 / Forkhead box protein Q1 / Q9C009* / forkhead box Q1*ENSMUSG000000384158
Foxh1 / O88621 / Forkhead box protein H1 / O75593* / forkhead box H1*ENSMUSG000000338378
Foxd4 / Q60688 / Forkhead box protein D4 / Q9NU39* / Q12950* / Q3SYB3* / Q5VV16* / Q6VB84* / Q8WXT5* / FOXD4L3* / FOXD4L4* / FOXD4L5* / FOXD4L6* / FOXD4L1* / forkhead box D4* / forkhead bo...ENSMUSG000000514908
Gm5294 / AC187653.1*ENSMUSG000000945047
Gm43517ENSMUSG000000899223


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR030456  Fork head domain conserved site 2
 IPR032354  FOXP, coiled-coil domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0048617 embryonic foregut morphogenesis IMP
 biological_processGO:0061140 lung secretory cell differentiation IGI
 biological_processGO:1901249 regulation of lung goblet cell differentiation IGI
 biological_processGO:1901250 negative regulation of lung goblet cell differentiation IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Clec7atm1Gdb/Clec7atm1Gdb
Genetic Background: B6.129S6-Clec7atm1Gdb

 MP:0000925 abnormal floor plate morphology "malformation or absence of a transient group of neuroepithelial cells located at the ventral midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clec7atm1Gdb/Clec7atm1Gdb
Genetic Background: B6.129S6-Clec7atm1Gdb

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Tmem107schlei/Tmem107tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C3HeB/FeJ * C57BL/6J * C57BL/6N

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp1tm1.1Pwt/Foxp1tm1.1Pwt,Foxp4tm2.1Eem/Foxp4tm2.1Eem,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clec7atm1Gdb/Clec7atm1Gdb
Genetic Background: B6.129S6-Clec7atm1Gdb

Allelic Composition: Foxp4Gt(RRF116)Byg/Foxp4tm1Eem
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Foxp4tm1Eem/Foxp4tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Clec7atm1Gdb/Clec7atm1Gdb
Genetic Background: B6.129S6-Clec7atm1Gdb

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Clec7atm1Gdb/Clec7atm1Gdb
Genetic Background: B6.129S6-Clec7atm1Gdb

 MP:0003115 abnormal respiratory system development "aberrant differentiation of pulmonary tissues" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tmem107schlei/Tmem107tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C3HeB/FeJ * C57BL/6J * C57BL/6N

Allelic Composition: Foxp1tm1.1Pwt/Foxp1tm1.1Pwt,Foxp4tm2.1Eem/Foxp4tm2.1Eem,Scgb1a1tm1(icre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003119 abnormal digestive system development "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003321 tracheoesophageal fistula "an abnormal passage between the esophagus and the trachea, acquired or congenital, often associated with esophageal atresia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004187 cardia bifida "failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
Show

Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
Show

Allelic Composition: Clec7atm1Gdb/Clec7atm1Gdb
Genetic Background: B6.129S6-Clec7atm1Gdb

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxp1tm1.1Pwt/Foxp1tm1.1Pwt,Foxp4tm2.1Eem/Foxp4tm2.1Eem,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006065 abnormal heart position "the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010949 decreased Clara cell number "reduced number of the rounded, club-shaped, nonciliated cells found between ciliated cells in bronchiolar epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmem107schlei/Tmem107tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C3HeB/FeJ * C57BL/6J * C57BL/6N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Foxp1tm1.1Pwt/Foxp1tm1.1Pwt,Foxp4tm2.1Eem/Foxp4tm2.1Eem,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Foxp4Gt(RRF116)Byg/Foxp4Gt(RRF116)Byg
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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