ENSMUSG00000038402


Mus musculus

Features
Gene ID: ENSMUSG00000038402
  
Biological name :Foxf2
  
Synonyms : Forkhead box protein F2 / Foxf2 / O54743
  
Possible biological names infered from orthology : forkhead box F2 / Q12947
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.2
Gene start: 31625816
Gene end: 31631403
  
Corresponding Affymetrix probe sets: 10404404 (MoGene1.0st)   1418220_at (Mouse Genome 430 2.0 Array)   1447562_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046789
NCBI entrez gene - 14238     See in Manteia.
MGI - MGI:1347479
RefSeq - NM_010225
RefSeq Peptide - NP_034355
swissprot - O54743
Ensembl - ENSMUSG00000038402
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxf2aENSDARG00000017195Danio rerio
 foxf2bENSDARG00000070389Danio rerio
 FOXF2ENSGALG00000031920Gallus gallus
 FOXF2ENSG00000137273Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxf1 / Q61080 / Forkhead box protein F1 / Q12946* / forkhead box F1*ENSMUSG0000004281248
Foxd2 / O35392 / Forkhead box protein D2 / O60548* / forkhead box D2*ENSMUSG0000005521025
Foxd3 / forkhead box D3 / Q9UJU5*ENSMUSG0000006726124
Foxd1 / Q61345 / Forkhead box protein D1 / Q16676* / forkhead box D1*ENSMUSG0000007830223
Foxe1 / Q8R2I0 / Forkhead box protein E1 / O00358* / forkhead box E1*ENSMUSG0000007099022
Foxd4 / Q60688 / Forkhead box protein D4 / Q9NU39* / Q12950* / Q3SYB3* / Q5VV16* / Q6VB84* / Q8WXT5* / FOXD4L3* / FOXD4L4* / FOXD4L5* / FOXD4L6* / FOXD4L1* / forkhead box D4* / forkhead bo...ENSMUSG0000005149020
Foxg1 / Q60987 / Forkhead box protein G1 / P55316* / forkhead box G1*ENSMUSG0000002095020
Foxq1 / O70220 / Forkhead box protein Q1 / Q9C009* / forkhead box Q1*ENSMUSG0000003841519
Foxh1 / O88621 / Forkhead box protein H1 / O75593* / forkhead box H1*ENSMUSG0000003383718
Foxe3 / Q9QY14 / Forkhead box protein E3 / Q13461* / forkhead box E3*ENSMUSG0000004451817
Foxp4 / Q9DBY0 / Forkhead box protein P4 / Q8IVH2* / forkhead box P4*ENSMUSG0000002399116
Gm5294 / AC187653.1*ENSMUSG0000009450415
Foxp1 / P58462 / Mus musculus forkhead box P1 (Foxp1), transcript variant 4, mRNA.ENSMUSG0000003006715
Foxp2 / P58463 / Forkhead box protein P2 / O15409* / forkhead box P2*ENSMUSG0000002956314
Foxp3 / Q99JB6 / Forkhead box protein P3 Forkhead box protein P3, C-terminally processed Forkhead box protein P3 41 kDa form / Q9BZS1* / forkhead box P3*ENSMUSG0000003952111
Gm43517ENSMUSG0000008992210


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0042249 establishment of planar polarity of embryonic epithelium IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048566 embryonic digestive tract development IGI
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IMP
 biological_processGO:0048806 genitalia development ISO
 biological_processGO:0060021 roof of mouth development ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IBA
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000431 absent palatine shelf "missing outgrowth of the palatine bone; normally fuses with maxillary shelf to form secondary palate " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Herc2jdf2-8R/Herc2jdf2-8R
Genetic Background: Not Specified

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
Show

Allelic Composition: Herc2jdf2-8R/Herc2jdf2-8R
Genetic Background: Not Specified

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Herc2jdf2-8R/Herc2jdf2-8R
Genetic Background: Not Specified

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002750 exophthalmos "protrusion of one or both eyeballs" [J:47965, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0004221 abnormal iridocorneal angle "any structural abnormality of the acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0004223 hypoplastic trabecular meshwork "reduced size of the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates" [MESH:A09.371.060.932, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0004226 absent Schlemm s canal "absence of the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0004448 abnormal presphenoid bone morphology "any structural anomaly of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0004453 abnormal pterygoid bone morphology "any structural anomaly of the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0004537 abnormal palatine shelf "any structural anomaly of the palatine bone; normally fuses with maxillary shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0004538 abnormal maxillary shelf "any structural anomaly of the outgrowth of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0005193 abnormal anterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005204 abnormal canal of Schlemm morphology "structural anomaly in the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005208 abnormal iris stroma morphology "structural anomaly of the lamellated connective tissue of the iris" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0006223 optic nerve swelling "accumulation of an excessive amount of fluid in the optic nerve; usually associated with an increase in intraocular pressure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0009247 meteorism "swelling of the abdomen resulting from gas in the intestinal or peritoneal cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0010704 abnormal optic canal morphology "any structural anomaly of the short canal through the orbitosphenoid bone at the apex of the orbit that gives passage to the optic nerve and the opthalmic artery" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Herc2jdf2-8R/Herc2jdf2-8R
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0011481 anterior iris synechia "adhesion of the iris to the cornea" [MGI:anna]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0013742 absent ciliary body "absence of the thickened portion of the vascular tunic, which lies between the choroid and the iris" [ISBN:0-683-40008-8, MGI:Anna]
Show

Allelic Composition: Herc2jdf2-8R/Herc2jdf2-8R
Genetic Background: Not Specified

 MP:0013743 ciliary body hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the thickened portion of the vascular tunic which lies between the choroid and the iris" [ISBN:0-683-40008-8, MGI:Anna]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0014163 abnormal ciliary muscle morphology "any structural anomaly of the ring of smooth muscle in the eye s vascular layer that forms the main part of the ciliary body, controls accommodation for viewing objects at varying distances, and regulates the flow of aqueous humor into the canal of Schlemm" [http://medical-dictionary.thefreedictionary.com/ciliary+muscle, https://en.wikipedia.org/wiki/Ciliary_muscle]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0014164 abnormal ciliary process morphology " any structural anomaly of any of the pigmented processes that radiate from the ciliary muscle and give attachments to ligaments supporting the lens of the eye; these processes increase in thickness as they advance from the orbiculus ciliaris to the external border of the iris, and together with the folds (plicae) in the furrows between them, constitute the corona ciliaris; ciliary processes produce aqueous humor" [http://www.medilexicon.com/medicaldictionary.php?s=processus+ciliaris]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0030290 absent soft palate "absence of the musculomembranous fold that partly separates the mouth and pharynx, located behind the hard palate in the adult" [MGI:anna]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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