ENSDARG00000021032


Danio rerio

Features
Gene ID: ENSDARG00000021032
  
Biological name :foxd3
  
Synonyms : forkhead box D3 / foxd3
  
Possible biological names infered from orthology : forkhead box D4 / forkhead box D4 like 1 / forkhead box D4 like 3 / forkhead box D4 like 4 / forkhead box D4 like 5 / forkhead box D4 like 6 / Forkhead box protein D4 / FOXD4 / FOXD4L1 / FOXD4L3 / FOXD4L4 / FOXD4L5 / FOXD4L6 / Q12950 / Q3SYB3 / Q5VV16 / Q60688 / Q6VB84 / Q8WXT5 / Q9NU39 / Q9UJU5
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 32092032
Gene end: 32093830
  
Corresponding Affymetrix probe sets: Dr.590.1.S1_at (Zebrafish Array)   NM_131290_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000107660
NCBI entrez gene - 30548     See in Manteia.
RefSeq - NM_131290
RefSeq Peptide - NP_571365
swissprot - F1R5S7
ZFIN ID - ZDB-GENE-980526-143
Ensembl - ENSDARG00000021032
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FOXD3ENSG00000187140Homo sapiens
 FOXD4ENSG00000170122Homo sapiens
 Q3SYB3ENSG00000273514Homo sapiens
 Q5VV16ENSG00000204779Homo sapiens
 Q6VB84ENSG00000187559Homo sapiens
 Q8WXT5ENSG00000184659Homo sapiens
 Q9NU39ENSG00000184492Homo sapiens
 Foxd3ENSMUSG00000067261Mus musculus
 Foxd4ENSMUSG00000051490Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
foxd2 / forkhead box D2 / FOXD1* / O35392* / O60548* / Q16676* / Q61345* / forkhead box D1* / Forkhead box protein D1 * / Forkhead box protein D2 *ENSDARG0000005813344
foxd1 / forkhead box D1 / FOXD2* / Q61345* / O35392* / O60548* / Q16676* / forkhead box D2* / Forkhead box protein D2 * / Forkhead box protein D1 *ENSDARG0000002917942
foxd5 / forkhead box D5 / FOXD1* / FOXD2* / Q16676* / Q61345* / O35392* / O60548* / forkhead box D2* / forkhead box D1* / Forkhead box protein D1 * / Forkhead box protein D2 *ENSDARG0000004248537
zgc:162612 / FOXD1* / FOXD2* / O60548* / Q61345* / Q16676* / O35392* / forkhead box D1* / forkhead box D2* / Forkhead box protein D1 * / Forkhead box protein D2 *ENSDARG0000007969933
foxe3 / forkhead box E3 / FOXE1* / O00358* / Q13461* / Q8R2I0* / Q9QY14* / forkhead box E1* / Forkhead box protein E1 * / Forkhead box protein E3 *ENSDARG0000006289229
foxg1a / forkhead box G1a / FOXG1* / P55316* / Q60987* / Gm43517* / forkhead box G1* / Forkhead box protein G1 *ENSDARG0000007076927
foxe1 / forkhead box E1 / FOXE3* / Q9QY14* / O00358* / Q13461* / Q8R2I0* / forkhead box E3* / Forkhead box protein E3 * / Forkhead box protein E1 *ENSDARG0000007926626
foxg1c / forkhead box G1cENSDARG0000006838025
foxf2a / forkhead box F2a / FOXF2* / O54743* / Q12947* / forkhead box F2* / Forkhead box protein F2 *ENSDARG0000001719524
foxf1 / A1L1S5 / forkhead box F1 / Q61080* / Q12946* / Forkhead box protein F1 *ENSDARG0000001539923
foxg1d / forkhead box G1dENSDARG0000007005323
foxg1b / forkhead box G1bENSDARG0000003270523
foxf2b / forkhead box F2b / FOXF2* / O54743* / Q12947* / forkhead box F2* / Forkhead box protein F2 *ENSDARG0000007038922
foxq1a / forkhead box Q1a / FOXQ1* / O70220* / Q9C009* / forkhead box Q1* / Forkhead box protein Q1 *ENSDARG0000003089621
si:dkey-7e14.3 / Gm5294* / AC187653.1*ENSDARG0000008605521
foxp4 / forkhead box P4ENSDARG0000007612019
foxq1b / forkhead box Q1b / FOXQ1* / O70220* / Q9C009* / forkhead box Q1* / Forkhead box protein Q1 *ENSDARG0000005539519
foxh1 / forkhead box H1 / O75593* / O88621* / Forkhead box protein H1 *ENSDARG0000005563019
foxq2 / forkhead box Q2ENSDARG0000007139418
foxp2 / forkhead box P2ENSDARG0000000545317


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0014032 neural crest cell development IMP
 biological_processGO:0030318 melanocyte differentiation IGI
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048484 enteric nervous system development IMP
 biological_processGO:0048485 sympathetic nervous system development IMP
 biological_processGO:0048937 lateral line nerve glial cell development IMP
 biological_processGO:0050931 pigment cell differentiation IMP
 biological_processGO:0050935 iridophore differentiation IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060351 cartilage development involved in endochondral bone morphogenesis IMP
 biological_processGO:0097066 response to thyroid hormone IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000013 cranial ganglion cranial ganglion axon damaged , abnormal
cranial ganglion axon defasciculated , abnormal
cranial ganglion axolemma damaged , abnormal
cranial ganglion neuronal cell body membrane broken , abnormal
cranial ganglion organelle damaged , abnormal
cranial ganglion cell body degenerate , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000077 tail bud tail bud morphology , abnormal
Show

 ZFA:0000084 yolk yolk melanophore stripe absent , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton decreased size , abnormal
pharyngeal arch 3-7 skeleton malformed , abnormal
pharyngeal arch 3-7 skeleton hypoplastic , abnormal
pharyngeal arch 3-7 skeleton morphology , abnormal
pharyngeal arch 3-7 skeleton quality , abnormal
pharyngeal arch 3-7 skeleton has fewer parts of type ceratobranchial cartilage , abnormal
Show

 ZFA:0000107 eye eye morphology , abnormal
eye decreased size , abnormal
Show

 ZFA:0000142 peripheral nervous system peripheral nervous system neuron distributed , abnormal
peripheral nervous system neuron decreased amount , abnormal
Show

 ZFA:0000155 somite somite increased width , abnormal
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 ZFA:0000200 dorsal root ganglion dorsal root ganglion decreased amount , abnormal
dorsal root ganglion irregular spatial pattern , abnormal
dorsal root ganglion lacks parts or has fewer parts of type glial cell (sensu Vertebrata) , abnormal
dorsal root ganglion neuron decreased amount , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000944 posterior lateral line posterior lateral line separated from melanocyte , abnormal
posterior lateral line has extra parts of type melanocyte , abnormal
Show

 ZFA:0001094 whole organism whole organism lacks all parts of type neural crest cell , abnormal
whole organism lacks all parts of type pharyngeal arch cartilage , abnormal
whole organism lacks all parts of type neural crest , abnormal
whole organism lacks all parts of type dorsal root ganglion , abnormal
whole organism lacks all parts of type enteric nervous system neuron, abnormal
whole organism lacks all parts of type mandibular arch skeleton , abnormal
whole organism lacks all parts of type melanocyte , abnormal
whole organism quality , abnormal
whole organism lacks all parts of type dorsal root ganglion neuron, abnormal
whole organism lacks all parts of type sympathetic nervous system neuron, abnormal
whole organism lacks all parts of type palatoquadrate arch , abnormal
whole organism lacks all parts of type ventral mandibular arch , abnormal
whole organism lacks all parts of type iridophore , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
head has fewer parts of type melanocyte , abnormal
head concave , abnormal
Show

 ZFA:0001115 trunk trunk has extra parts of type melanocyte , abnormal
trunk dorsal region has fewer parts of type iridophore , abnormal
trunk iridophore decreased amount , abnormal
Show

 ZFA:0001117 post-vent region post-vent region has extra parts of type melanocyte , abnormal
Show

 ZFA:0001155 enteric nervous system enteric nervous system neuron decreased amount , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage mislocalised ventrally , abnormal
Meckels cartilage curved ventral , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton disorganized , abnormal
mandibular arch skeleton protruding , abnormal
Show

 ZFA:0001276 pharyngeal arch 2 skeleton pharyngeal arch 2 skeleton morphology , abnormal
pharyngeal arch 2 skeleton decreased size , abnormal
pharyngeal arch 2 skeleton malformed , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch tendon absent , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage decreased size , abnormal
ceratohyal cartilage malformed , abnormal
Show

 ZFA:0001405 ethmoid cartilage ethmoid cartilage curved ventral , abnormal
ethmoid cartilage aplastic , abnormal
Show

 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage decreased size , abnormal
hyosymplectic cartilage malformed , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage decreased size , abnormal
pharyngeal arch cartilage absent , abnormal
Show

 ZFA:0001462 somite border somite border irregular spatial pattern , abnormal
Show

 ZFA:0001463 melanophore stripe melanophore stripe decreased amount , abnormal
melanophore stripe melanocyte decreased amount , abnormal
Show

 ZFA:0001508 trabecula communis trabecula communis absent , abnormal
Show

 ZFA:0001510 basihyal cartilage basihyal cartilage absent , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage decreased amount , abnormal
ceratobranchial cartilage absent , abnormal
ceratobranchial cartilage malformed , abnormal
Show

 ZFA:0001555 epibranchial ganglion epibranchial ganglion degenerate , abnormal
Show

 ZFA:0001576 sympathetic nervous system sympathetic nervous system neuron absent , abnormal
sympathetic nervous system neuron decreased amount , abnormal
Show

 ZFA:0001580 neurocranium neurocranium deformed , abnormal
neurocranium lacks all parts of type ethmoid cartilage , abnormal
neurocranium lacks all parts of type trabecula cranii , abnormal
neurocranium decreased size , abnormal
neurocranium anterior region aplastic , abnormal
Show

 ZFA:0001611 pharyngeal arch 2 pharyngeal arch 2 disorganized , abnormal
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 ZFA:0001612 pharyngeal arch 1 pharyngeal arch 1 fused with pharyngeal arch 2 , abnormal
Show

 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 hypoplastic , abnormal
Show

 ZFA:0005777 sympathetic neuron sympathetic neuron absent , abnormal
Show

 ZFA:0007067 vagal ganglion vagal ganglion malformed , abnormal
vagal ganglion glial cell absent , abnormal
Show

 ZFA:0009091 melanocyte melanocyte increased amount , abnormal
melanocyte irregular spatial pattern , abnormal
melanocyte decreased amount , abnormal
melanocyte position , abnormal
melanocyte spatial pattern , abnormal
Show

 ZFA:0009198 xanthophore xanthophore quality , abnormal
xanthophore decreased amount , abnormal
Show

 ZFA:0009199 iridophore iridophore decreased amount , abnormal
iridophore quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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