ENSG00000187140


Homo sapiens

Features
Gene ID: ENSG00000187140
  
Biological name :FOXD3
  
Synonyms : forkhead box D3 / FOXD3 / Q9UJU5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p31.3
Gene start: 63323041
Gene end: 63325126
  
Corresponding Affymetrix probe sets: 208500_x_at (Human Genome U133 Plus 2.0 Array)   241609_at (Human Genome U133 Plus 2.0 Array)   241612_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360157
NCBI entrez gene - 27022     See in Manteia.
OMIM - 611539
RefSeq - NM_012183
RefSeq Peptide - NP_036315
swissprot - Q9UJU5
Ensembl - ENSG00000187140
  
Related genetic diseases (OMIM): 607836 - {Autoimmune disease, susceptibility to, 1}, 607836

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxd3ENSDARG00000021032Danio rerio
 Foxd3ENSMUSG00000067261Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FOXD1 / Q16676 / forkhead box D1ENSG0000025149341
FOXD2 / O60548 / forkhead box D2ENSG0000018656437
Q9NU39 / FOXD4L1 / forkhead box D4 like 1ENSG0000018449229
FOXD4 / Q12950 / forkhead box D4ENSG0000017012229
Q6VB84 / FOXD4L3 / forkhead box D4 like 3ENSG0000018755928
Q3SYB3 / FOXD4L6 / forkhead box D4 like 6ENSG0000027351428
Q8WXT5 / FOXD4L4 / forkhead box D4 like 4ENSG0000018465928
Q5VV16 / FOXD4L5 / forkhead box D4 like 5ENSG0000020477928
FOXG1 / P55316 / forkhead box G1ENSG0000017616523
FOXE1 / O00358 / forkhead box E1ENSG0000017891922
FOXF2 / Q12947 / forkhead box F2ENSG0000013727322
FOXE3 / Q13461 / forkhead box E3ENSG0000018679022
FOXQ1 / Q9C009 / forkhead box Q1ENSG0000016437921
AC187653.1ENSG0000024876719
FOXF1 / Q12946 / forkhead box F1ENSG0000010324119
FOXP2 / O15409 / forkhead box P2ENSG0000012857315
FOXP4 / Q8IVH2 / forkhead box P4ENSG0000013716615
FOXH1 / O75593 / forkhead box H1ENSG0000016097314
FOXP1 / Q9H334 / forkhead box P1ENSG0000011486113
FOXP3 / Q9BZS1 / forkhead box P3ENSG0000004976810


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001701 in utero embryonic development ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035019 somatic stem cell population maintenance TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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