ENSMUSG00000024914


Mus musculus

Features
Gene ID: ENSMUSG00000024914
  
Biological name :Drap1
  
Synonyms : Dr1-associated corepressor / Drap1 / Q9D6N5
  
Possible biological names infered from orthology : DR1 associated protein 1 / Q14919
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 5422805
Gene end: 5424979
  
Corresponding Affymetrix probe sets: 10465045 (MoGene1.0st)   1451676_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121162
Ensembl peptide - ENSMUSP00000109303
Ensembl peptide - ENSMUSP00000025853
Ensembl peptide - ENSMUSP00000133692
Ensembl peptide - ENSMUSP00000109304
NCBI entrez gene - 66556     See in Manteia.
MGI - MGI:1913806
RefSeq - NM_024176
RefSeq - NM_001291080
RefSeq Peptide - NP_077138
RefSeq Peptide - NP_001278009
swissprot - Q9D6N5
swissprot - D3YY09
swissprot - D3YYC2
swissprot - F6T9K1
swissprot - G3UXH5
swissprot - Q4FJW2
Ensembl - ENSMUSG00000024914
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 drap1ENSDARG00000041203Danio rerio
 DRAP1ENSG00000175550Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003958  Transcription factor CBF/NF-Y/archaeal histone domain
 IPR009072  Histone-fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IDA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
Signaling by Activin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Runx1tm1Sata/Runx1tm1Sata
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Runx1tm1Sata/Runx1tm1Sata
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0002174 abnormal gastrulation movements "failure of embryonic cells to migrate, or migrate to the appropriate target during the development and invagination of the primary germ layers" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:52418]
Show

Allelic Composition: Runx1tm1Sata/Runx1tm1Sata
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm1Sata/Runx1tm1Sata
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0009266 abnormal mesendoderm development "failure or abnormality in the formation of the embryonic cell layer that gives rise to both the endoderm and mesoderm" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1tm1Sata/Runx1tm1Sata
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Runx1tm1Sata/Runx1tm1Sata
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0012184 absent paraxial mesoderm "absence or loss of the mesoderm normally found at either side of the midline embryonic notochord that, on segmentation, forms the paired somites." [MGI:anna]
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Allelic Composition: Runx1tm1Sata/Runx1tm1Sata
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0012274 increased axial mesoderm size "greater than average size of the part of the middle of the three primary germ layers of the embryo which includes the prechordal mesoderm and the chordamesoderm and gives rise to the prechordal plate and to the notochord" [MGI:anna]
Show

Allelic Composition: Runx1tm1Sata/Runx1tm1Sata
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033837 Foxh1 / O88621 / Forkhead box protein H1 / O75593* / forkhead box H1*  / complex






 

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