| MP:0000060 | delayed bone ossification | "late onset of the formation of bone" [J:40203] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0000120 | malocclusion | "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
Allelic Composition: Smad4tm2.1Cxd/Smad4+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0000130 | abnormal cancellous bone morphology | "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0000135 | reduced cortical bone thickness | "thinner than normal superficial layer of compact bone " [J:61509] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0000284 | double outlet right ventricle | "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826] |
Show
Allelic Composition: Atxn1tm1Hzo/Atxn1+,CicGt(XE565)Byg/Cic+
Genetic Background: B6.129-CicGt(XE565)Byg Atxn1tm1Hzo
|
| MP:0000298 | absent endocardial cushion | "absence of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [MGI:CLS] |
Show
Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
|
| MP:0000352 | decreased cell proliferation | "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Smad4tm1Mak/Smad4tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * CD-1)
|
| MP:0000377 | abnormal hair follicle | "malformed invagination of the epidermis from which the hair shaft develops" [J:65031] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
|
| MP:0000381 | enlarged hair follicles | "increased size of the epidermal invaginations from which the hair shaft develops" [J:30249] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0000414 | alopecia | "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
|
| MP:0000473 | abnormal stomach glandular epithelium morphology | "malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637] |
Show
Allelic Composition: Smad4m4Mag/Smad4+
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6
|
| MP:0000489 | abnormal large intestine morphology | "structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smad4m4Mag/Smad4+
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6
|
| MP:0000494 | abnormal cecum morphology | "malformation of the large sac at the ileum and large intestine junction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad4m4Mag/Smad4+
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6
|
| MP:0000496 | abnormal small intestine morphology | "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smad4m4Mag/Smad4+
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6
|
| MP:0000527 | abnormal kidney development | "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Bmp7tm6(cre)Rob/Bmp7+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
|
| MP:0000536 | hydroureter | "distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044] |
Show
Allelic Composition: Bmp7tm6(cre)Rob/Bmp7+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
|
| MP:0000558 | abnormal tibia morphology | "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0000599 | enlarged liver | "larger than average size of the liver" [J:65146] |
Show
Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
|
| MP:0000652 | enlarged sebaceous gland | "increased size of the sebum secreting glands of the hair shaft" [J:30249] |
Show
Allelic Composition: Krastm4Tyj/Kras+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL/J
|
| MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak Smad4E6sad/+ +
|
| MP:0000706 | small thymus | "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167] |
Show
Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J
|
| MP:0000880 | decreased Purkinje cell number | "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302] |
Show
Allelic Composition: Clip1tm1Gal/Clip1tm1Gal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000889 | abnormal cerebellar molecular layer | "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
Show
Allelic Composition: Clip1tm1Gal/Clip1tm1Gal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000933 | abnormal rhombomere morphology | "malformation of the transverse segments in the hindbrain region of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776] |
Show
Allelic Composition: Smad4tm1.1Rob/Smad4+
Genetic Background: involves: 129S/SvEv * CD-1
|
| MP:0001130 | abnormal ovarian folliculogenesis | "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782] |
Show
Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0001131 | abnormal ovarian follicles | "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042] |
Show
Allelic Composition: Mbd2tm1Bh/Mbd2tm1Bh,Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0001200 | thick skin | "greater depth of skin " [J:47225] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0001219 | thickened epidermis | "increase in the width of the epidermal cell layer in the skin" [J:65146] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
|
| MP:0001242 | hyperkeratosis | "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
Show
Allelic Composition: Hand1tm3Abfi/Hand1+,Tg(Mpz-cre)94Imeg/0
Genetic Background: Not Specified
|
| MP:0001272 | increased metastatic potential | |
Show
Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Smad4tm1Rdp/Smad4tm1Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Cdh1tm2Kem/Cdh1+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Cdh1tm2Kem/Cdh1+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N
|
| MP:0001577 | anemia | "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
Show
Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak Smad4E6sad/+ +
|
| MP:0001672 | abnormal embryogenesis/ development | "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Trim33tm1.2Los/Trim33tm1.2Los
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Smad4tm1Rdp/Smad4tm1.1Rdp,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL
|
| MP:0001675 | abnormal ectoderm development | "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad4tm1Mak/Smad4tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * CD-1)
|
| MP:0001680 | abnormal mesoderm development | "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad4tm1Mak/Smad4tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * CD-1)
|
| MP:0001683 | absent mesoderm | "missing or failure to differentiate the middle primary germ layer " [J:40594] |
Show
Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Smad4tm1Mak/Smad4tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * CD-1)
Allelic Composition: Smad4m4Mag/Smad4tm1Cxd
Genetic Background: either: (involves: 129S/Sv * 129S6/SvEvTac * Black Swiss) or (involves: 129S/Sv * 129S6/SvEvTac * C57BL/6)
Allelic Composition: Smad4m4Mag/Smad4m4Mag
Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)
|
| MP:0001685 | abnormal endoderm development | "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Smad4tm1.1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * CD-1
|
| MP:0001693 | failure of primitive streak formation | "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880] |
Show
Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Smad4tm1Mak/Smad4tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * CD-1)
|
| MP:0001694 | failure to form egg cylinders | "inability of inner cell mass cells to grow towards the abembryonic pole to form a cylinder-like structure" [The Atlas of Mouse Development , Revised edition:ISBN 0-12-402035-6, MGI:cls, J:34458] |
Show
Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6
|
| MP:0001696 | failure to gastrulate | "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458] |
Show
Allelic Composition: Smad4tm1Mak/Smad4tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * CD-1)
Allelic Composition: Smad4m4Mag/Smad4tm1Cxd
Genetic Background: either: (involves: 129S/Sv * 129S6/SvEvTac * Black Swiss) or (involves: 129S/Sv * 129S6/SvEvTac * C57BL/6)
Allelic Composition: Smad4m4Mag/Smad4m4Mag
Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)
|
| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
Show
Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Smad4tm1Mak/Smad4tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * CD-1)
|
| MP:0001704 | abnormal dorsal-ventral axis patterning | "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad4tm1Rob/Smad4tm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * CD-1
|
| MP:0001705 | abnormal proximal-distal axis patterning | "anomaly in the formation or development of a body structure, often a limb, in relation to the structure s proximity to the trunk or point of origin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0001726 | abnormal allantois | "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622] |
Show
Allelic Composition: Smad4tm1.1Rob/Smad4+
Genetic Background: involves: 129S/SvEv * CD-1
|
| MP:0001730 | embryonic growth arrest | "the cessation of development beyond a particular stage" [J:17509] |
Show
Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Smad4tm1Mak/Smad4tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * CD-1)
|
| MP:0001883 | mammary adenocarcinoma | "higher than normal incidence of malignant tumors of the mammary gland" [J:62919] |
Show
Allelic Composition: Apctm2Rfo/Apc+,Smad4E6sad/Smad4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Cdh1tm2Kem/Cdh1+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N
|
| MP:0001924 | infertility | "inability to produce live offspring" [J:47225] |
Show
Allelic Composition: Mbd2tm1Bh/Mbd2tm1Bh,Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0001935 | reduced litter size | "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0001944 | abnormal pancreas morphology | "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129 * C57BL/6 * FVB/N
|
| MP:0002014 | papilloma | "benign epithelial tumor" [J:47225] |
Show
Allelic Composition: Krastm4Tyj/Kras+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL/J
|
| MP:0002015 | epithelioid cysts | "abnormal membraneous sacs appearing in an epithelium" [J:51296] |
Show
Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
|
| MP:0002020 | increased tumor incidence | "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193] |
Show
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Smad4m4Mag/Smad4+
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6
|
| MP:0002038 | carcinoma | "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
|
| MP:0002051 | skin papilloma | "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
|
| MP:0002052 | decreased tumor incidence | "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: B6.129S-Rag2tm1Fwa Mmp9tm1Tvu
|
| MP:0002073 | abnormal hair growth | "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Krastm4Tyj/Kras+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL/J
|
| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Apctm1Mmt/Apc+,Smad4tm1Mmt/Smad4+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Allelic Composition: Smad4tm1Rob/Smad4tm1.1Rob,Tg(Hoxb7-cre)1Rob/0
Genetic Background: involves: 129S/SvEv
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Smad4E6sad
Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak Smad4E6sad/+ +
Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak +/+ Smad4E6sad
Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Smad4tm1Rdp/Smad4tm1Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
Allelic Composition: Cdh1tm2Kem/Cdh1+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
|
| MP:0002085 | abnormal embryonic tissue morphology | "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Smad4tm1Mak/Smad4tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * CD-1)
|
| MP:0002086 | abnormal extraembryonic tissue morphology | "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6
|
| MP:0002100 | abnormal tooth morphology | "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Inhbetm2Zuk/Inhbetm2Zuk
Genetic Background: either: (involves: 129S5/SvEvBrd * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)
Allelic Composition: Smad4m1Mag/Smad4tm1Cxd
Genetic Background: either: (involves: 129S/Sv * 129S6/SvEvTac * Black Swiss) or (involves: 129S/Sv * 129S6/SvEvTac * C57BL/6)
Allelic Composition: Smad4m2Mag/Smad4tm1Cxd
Genetic Background: either: (involves: 129S/Sv * 129S6/SvEvTac * Black Swiss) or (involves: 129S/Sv * 129S6/SvEvTac * C57BL/6)
Allelic Composition: Smad4m3Mag/Smad4tm1Cxd
Genetic Background: either: (involves: 129S/Sv * 129S6/SvEvTac * Black Swiss) or (involves: 129S/Sv * 129S6/SvEvTac * C57BL/6)
Allelic Composition: Smad4m3Mag/Smad4m3Mag
Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)
Allelic Composition: Smad4m2Mag/Smad4m2Mag
Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)
Allelic Composition: Smad4m1Mag/Smad4m1Mag
Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)
Allelic Composition: Smad4tm2.1Rob/Smad4tm2.1Rob
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CBA)
Allelic Composition: Smad4tm1.1Rob/Smad4tm2.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6
Allelic Composition: Smad4tm3Rob/Smad4tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6
|
| MP:0002404 | intestinal adenoma | "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad4E6sad/Smad4E6sad
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak Smad4E6sad/+ +
Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak +/+ Smad4E6sad
|
| MP:0002574 | increased vertical activity | "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Clip1tm1Gal/Clip1tm1Gal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0002576 | abnormal enamel morphology | "malformation of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0002582 | disorganized extraembryonic tissue | "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad4tm1Mak/Smad4tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * CD-1)
|
| MP:0002584 | small ectoplacental cone | |
Show
Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6
|
| MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
|
| MP:0002655 | abnormal keratinocyte morphology | "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0002682 | reduced number of mature ovarian follicles | "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0002732 | trichoepithelioma | "benign hair follicle tumors that lack mature hair follicles, derived from basal cells of the hair follicles enclosing small keratin cysts" [il:Ira Lu , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J
|
| MP:0002764 | short tibia | " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0002928 | abnormal bile duct morphology | "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
|
| MP:0002957 | intestinal adenocarcinoma | "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Apctm1Mmt/Apc+,Smad4tm1Mmt/Smad4+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak +/+ Smad4E6sad
Allelic Composition: Cdh1tm2Kem/Cdh1+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2
|
| MP:0002981 | increased liver weight | "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
|
| MP:0002989 | small kidney | "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Bmp7tm6(cre)Rob/Bmp7+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
|
| MP:0003229 | abnormal vitelline vasculature | "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac
|
| MP:0003269 | colonic polyps | "abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Smad4E6sad
|
| MP:0003271 | abnormal duodenum morphology | "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Smad4m4Mag/Smad4+
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6
|
| MP:0003299 | gastric polyps | "abnormal tissue masses that protrude into the lumen of the stomach and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Smad4tm1Mmt/Smad4tm1Mmt
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Smad4m4Mag/Smad4+
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6
Allelic Composition: Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Smad4E6sad
Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak Smad4E6sad/+ +
Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak +/+ Smad4E6sad
|
| MP:0003334 | pancreatic fibrosis | "invasion of fibrous connective tissue into the pancreas, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
Show
Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
|
| MP:0003336 | pancreatic cysts | "the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman, NCBI request] |
Show
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
|
| MP:0003341 | chronic pancreas inflammation | "persistant inflammatory response in the pancreas, often caused by persistant infection or during an autoimmune response" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
Show
Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
|
| MP:0003355 | reduced ovulation | "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0003396 | abnormal embryonic hematopoiesis | "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans
" [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac
|
| MP:0003413 | hair follicle degeneration | "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517] |
Show
Allelic Composition: Krastm4Tyj/Kras+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL/J
|
| MP:0003414 | epidermal cyst | "a cyst formed of a mass of epidermal cells which is present beneath the epidermis; the wall is lined with stratified squamous epithelium and exhibits increased/abnormal keratinization" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Apctm1Mmt/Apc+,Smad4tm1Mmt/Smad4+
Genetic Background: involves: 129S2/SvPas * C57BL/6
|
| MP:0003447 | reduced tumor growth/size | "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383] |
Show
Allelic Composition: Apctm1Mmt/Apc+,Mmp7tm1Lmm/Mmp7tm1Lmm,Smad4tm1Mmt/Smad4+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
|
| MP:0003450 | enlarged pancreas | "increase of the size of the pancreas compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
|
| MP:0003453 | abnormal keratinocyte physiology | "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0003675 | kidney cysts | "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Bmp7tm6(cre)Rob/Bmp7+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
|
| MP:0003705 | abnormal hypodermis morphology | "malformed or atypical condition of the innermost and thickest layer of the skin composed of loose connective tissue containing adipoctyes" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0003763 | abnormal thymus physiology | "anomalous function of the primary lymphoid organ that is required for immune system development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J
|
| MP:0003875 | abnormal hair follicle regresssion | "abnormal length of time for the onset of catagen phase of the cyclic trasnformation of the hair follicle
" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
|
| MP:0003886 | abnormal embryonic epiblast morphology | "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad4tm1.1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * CD-1
|
| MP:0003890 | abnormal embryonic-extraembryonic boundary morphology | "anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Smad4tm1Mak/Smad4tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * CD-1)
|
| MP:0003920 | abnormal right ventricle morphology | "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Atxn1tm1Hzo/Atxn1+,CicGt(XE565)Byg/Cic+
Genetic Background: B6.129-CicGt(XE565)Byg Atxn1tm1Hzo
|
| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad4m4Mag/Smad4tm1Cxd
Genetic Background: either: (involves: 129S/Sv * 129S6/SvEvTac * Black Swiss) or (involves: 129S/Sv * 129S6/SvEvTac * C57BL/6)
Allelic Composition: Smad4m4Mag/Smad4m4Mag
Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)
Allelic Composition: Smad4E6sad/Smad4E6sad
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0004067 | abnormal ventricular trabeculae morphology | "aberrant structure of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(ACTA1-cre)AMcle/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0004148 | increased cortical bone thickness | "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0004207 | squamous cell carcinoma | "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Cdh1tm2Kem/Cdh1+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
|
| MP:0004214 | abnormal long bone diaphysis morphology | "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0004337 | clavicle hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells, of one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0004675 | rib fractures | "a crack or break in the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0004734 | small thoracic cavity | "reduced size of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0004985 | decreased osteoclast cell number | "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0005006 | abnormal osteoblast function | "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0005169 | abnormal male meiosis | "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ano1tm1.1Jwo/Ano1tm1.1Jwo,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0005186 | increased circulating progesterone level | "greater than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817] |
Show
Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0005210 | disorganized gastric mucosa | "disorderly structure of the stomach epithelium" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:77398] |
Show
Allelic Composition: Smad4m4Mag/Smad4+
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6
|
| MP:0005215 | abnormal islet of Langerhans morphology | "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
|
| MP:0005221 | abnormal rostral-caudal axis patterning | "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Smad4tm1Rob/Smad4tm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * CD-1
|
| MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Bmp7tm6(cre)Rob/Bmp7+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
|
| MP:0005431 | oocyte depletion | "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0005493 | stomach epithelial hyperplasia | |
Show
Allelic Composition: Smad4E6sad/Smad4E6sad
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0006108 | abnormal hindbrain development | "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573] |
Show
Allelic Composition: Smad4tm1Rob/Smad4tm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * CD-1
|
| MP:0008000 | ovary tumor | "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smad4m4Mag/Smad4+
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6
|
| MP:0008010 | gastric adenocarcinoma | "malignant neoplasm of epithelial cells in the stomach" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Cdh1tm2Kem/Cdh1+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Cdh1tm2Kem/Cdh1tm2Kem,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
|
| MP:0008011 | intestinal polyps | "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Smad4E6sad
Allelic Composition: Apctm1Rak/Apc+,Smad4E6sad/Smad4+
Genetic Background: B6.129P2-Apctm1Rak Smad4E6sad/+ +
|
| MP:0008012 | duodenal polyps | "development of numerous growths that are connected to and protrude from the mucous membrane of the duodenum" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smad4tm1Mmt/Smad4tm1Mmt
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA * FVB/N
|
| MP:0008014 | lung tumor | "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smad4m4Mag/Smad4+
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6
|
| MP:0008156 | decreased diameter of tibia | "reduced width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0008393 | absent primordial germ cells | "absence of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smad4tm1Rob/Smad4tm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * CD-1
|
| MP:0008753 | abnormal osteocyte morphology | "any structural anomaly of a mature osteoblast that has become embedded in the bone matrix (osteoid) in small cavities called lacuna and is connected to adjacent osteocytes via protoplasmic projections called canaliculi" [MESH:A.11.329.629.500] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0008868 | abnormal granulosa cell morphology | "any structural anomaly of a supporting cell for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle" [MESH:A.05.360.319.114.630.535.200] |
Show
Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0009143 | abnormal pancreatic duct morphology | "any structural anomaly of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667] |
Show
Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
|
| MP:0009144 | dilated pancreatic duct | "an increase in volume of the luminal space of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667] |
Show
Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
|
| MP:0009146 | abnormal pancreatic acinar cell morphology | "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
|
| MP:0009151 | pancreatic ductal adenocarcinoma | "adenocarcinoma that arises from the pancraetic ducts" [MESH:C04.557.470.200.025.232.750] |
Show
Allelic Composition: Apctm1Mmt/Apc+,Smad4tm1Mmt/Smad4+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
|
| MP:0009152 | pancreatic intraepithelial neoplasia | "noninvasive pancreatic duct lesions that affect smaller caliber ducts and do not involve the main pancreatic duct" [PMID:11342768] |
Show
Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
|
| MP:0009220 | prostate adenocarcinoma | "malignant neoplasm arising from prostate tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Smad4tm1Rdp/Smad4tm1Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2
|
| MP:0009311 | duodenum adenocarcinoma | "malignant neoplasm of epithelial cells in the duodenum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Cdh1tm2Kem/Cdh1+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
|
| MP:0009363 | abnormal secondary ovarian follicle morphology | "any structural abnormality in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0009373 | abnormal cumulus expansion | "defective or reduced ability of the cumulus cells to synthesize and accumulate hyaluronan into an extracellular matrix (ECM), which provides an essential microenvironment for oocyte fertilization; this expanded ECM binds the oocyte and the cumulus cells together, protects the oocyte from the proteolytic and mechanical stresses during extrusion, and allows sperm binding, penetration, and fertilization" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0009374 | failure of cumulus expansion | "complete inability of the cumulus cells to secrete an extensive extracellular matrix required for successful fertilization" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0009583 | increased keratinocyte proliferation | "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
|
| MP:0009704 | skin squamous cell carcinoma | "a skin carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J
|
| MP:0009715 | thick epidermis stratum basale | "increased thickness of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0009931 | abnormal skin appearance | "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0010224 | abnormal heart ventricle outflow tract morphology | "any structural anomaly of the superior portion of the ventricles of the heart through which blood flows into the arteries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(ACTA1-cre)AMcle/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0010279 | increased gastrointestinal tumor incidence | "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Apctm2Rfo/Apc+,Smad4E6sad/Smad4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0010300 | increased skin tumor incidence | "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J
|
| MP:0010301 | increased stomach tumor incidence | "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Allelic Composition: Smad4tm1.1Rob/Smad4+
Genetic Background: involves: 129S/SvEv * CD-1
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Smad4m4Mag/Smad4+
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6
Allelic Composition: Smad4E6sad/Smad4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0010308 | decreased tumor latency | "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
|
| MP:0010315 | increased cholangiocarcinoma incidence | "greater than the expected number of malignant adenocarcimomas arising in the intrahepatic bile duct epithelium, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
|
| MP:0010383 | increased adenoma incidence | "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035] |
Show
Allelic Composition: Krastm4Tyj/Kras+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J
|
| MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(ACTA1-cre)AMcle/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0010556 | thin ventricle myocardium compact layer | "reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(ACTA1-cre)AMcle/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0010690 | thick hair follicle outer rooth sheath | "increased thickness of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
|
| MP:0010970 | abnormal compact bone lamellar structure | "any structural anomaly of the concentric layers of calcified matrix interspersed with osteocytes lodged in lacunae between the lamellae that comprise the cylindrical osteons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
Show
Allelic Composition: Bmp7tm6(cre)Rob/Bmp7+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
|
| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
Show
Allelic Composition: Bmp7tm6(cre)Rob/Bmp7+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
|
| MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
Show
Allelic Composition: Smad4E6sad/Smad4E6sad
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(ACTA1-cre)AMcle/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
Show
Allelic Composition: Clip1tm1Gal/Clip1tm1Gal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0011096 | complete embryonic lethality before somite formation | "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith] |
Show
Allelic Composition: Smad4tm1Mak/Smad4tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * CD-1)
Allelic Composition: Smad4tm1Mmt/Smad4tm1Mmt
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Smad4tm2Cxd/Smad4tm2Cxd
Genetic Background: involves: Black Swiss
Allelic Composition: Smad4tm2.2Cxd/Smad4tm2.2Cxd
Genetic Background: involves: Black Swiss
Allelic Composition: Smad4m4Mag/Smad4tm1Cxd
Genetic Background: either: (involves: 129S/Sv * 129S6/SvEvTac * Black Swiss) or (involves: 129S/Sv * 129S6/SvEvTac * C57BL/6)
Allelic Composition: Smad4m4Mag/Smad4m4Mag
Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)
|
| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
Show
Allelic Composition: Smad4tm1Rob/Smad4tm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * CD-1
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac
|
| MP:0011106 | partial embryonic lethality before somite formation | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith] |
Show
Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6
|
| MP:0011107 | partial embryonic lethality before turning of embryo | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith] |
Show
Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6
|
| MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(ACTA1-cre)AMcle/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0011186 | abnormal visceral endoderm morphology | "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814] |
Show
Allelic Composition: Smad4tm1Mak/Smad4tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * CD-1)
Allelic Composition: Smad4tm1.1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * CD-1
|
| MP:0011192 | decreased embryonic epiblast cell proliferation | "reduction in the expansion rate of the embryonic epiblast cells by cell division" [MGI:anna] |
Show
Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6
|
| MP:0011642 | abnormal bone collagen fibril morphology | "any structural anomaly of the connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
| MP:0011733 | fused somites | "a defect in which there is an appearance of a single enlarged somite resulting from partial or complete fusion of the two somitic anlage" [MGI:smb] |
Show
Allelic Composition: Smad4tm1Rob/Smad4tm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * CD-1
|
| MP:0011846 | decreased kidney collecting duct number | "smaller than expected number of the kidney ducts that collect urine from the distal convoluted tubules, merge and become larger as they descend from the renal cortex into the medulla, and respond to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance" [MGI:anna] |
Show
Allelic Composition: Bmp7tm6(cre)Rob/Bmp7+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
|
| MP:0012083 | absent foregut | "absence of the anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder" [MGI:anna] |
Show
Allelic Composition: Smad4tm1Rob/Smad4tm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * CD-1
|
| MP:0012086 | absent hindgut | "absence of the caudal portion of the primitive digestive tube of the embryo" [MGI:anna] |
Show
Allelic Composition: Smad4tm1Rob/Smad4tm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * CD-1
|
| MP:0012095 | increased Reichert s membrane thickness | "increased width of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm during placenta morphogenesis and is secreted by the distal parietal endoderm" [MGI:anna] |
Show
Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6
|
| MP:0012113 | decreased inner cell mass proliferation | |
Show
Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6
|
| MP:0012157 | rostral body truncation | "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith] |
Show
Allelic Composition: Smad4tm1Mak/Smad4tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * CD-1)
|
| MP:0012159 | absent anterior visceral endoderm | "absence of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:anna] |
Show
Allelic Composition: Trim33tm1.2Los/Trim33tm1.2Los
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Smad4tm1Rdp/Smad4tm1.1Rdp,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL
|
| MP:0013221 | pancreatic acinar-to-ductal metaplasia | "a reprogramming event that induces transdifferentiation of pancreatic acinar cells to a duct-like phenotype in response to inflammatory injury; ADM is associated with an increased risk of exocrine pancreatic cancer and is considered a precursor of pancreatic ductal adenocarcinoma" [MGI:anna] |
Show
Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
|
| MP:0030079 | small incisors | "reduced size of the set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna] |
Show
Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
