ENSMUSG00000028252


Mus musculus

Features
Gene ID: ENSMUSG00000028252
  
Biological name :Ccnc
  
Synonyms : Ccnc / Cyclin-C / Q62447
  
Possible biological names infered from orthology : P24863
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A3
Gene start: 21727701
Gene end: 21759922
  
Corresponding Affymetrix probe sets: 10503534 (MoGene1.0st)   1417861_at (Mouse Genome 430 2.0 Array)   1428570_at (Mouse Genome 430 2.0 Array)   1432754_at (Mouse Genome 430 2.0 Array)   1454144_a_at (Mouse Genome 430 2.0 Array)   1454336_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069076
Ensembl peptide - ENSMUSP00000100062
Ensembl peptide - ENSMUSP00000103875
Ensembl peptide - ENSMUSP00000113682
NCBI entrez gene - 51813     See in Manteia.
MGI - MGI:1858199
RefSeq - NM_001290422
RefSeq - NM_001122982
RefSeq - NM_001290420
RefSeq - NM_016746
RefSeq Peptide - NP_001116454
RefSeq Peptide - NP_001277349
RefSeq Peptide - NP_001277351
RefSeq Peptide - NP_058026
swissprot - Q3UXL9
swissprot - Q62447
swissprot - Q8CAS3
Ensembl - ENSMUSG00000028252
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccncENSDARG00000009607Danio rerio
 CCNCENSGALG00000015471Gallus gallus
 CCNCENSG00000112237Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccnk / cyclin K / O75909*ENSMUSG0000002125828
Ccnl2 / Q9JJA7 / Cyclin-L2 / Q96S94*ENSMUSG0000002906825
Ccnl1 / Q52KE7 / Mus musculus cyclin L1 (Ccnl1), transcript variant 2, mRNA. / Q9UK58* / cyclin L1*ENSMUSG0000002782925
Ccnt2 / Q7TQK0 / Cyclin-T2 / O60583*ENSMUSG0000002634924
Ccnt1 / Q9QWV9 / Cyclin-T1 / O60563*ENSMUSG0000001196022
Fam58b / Q8QZR8 / family with sequence similarity 58, member B / CCNQ* / Q8N1B3* / cyclin Q*ENSMUSG0000004948918


Protein motifs (from Interpro)
Interpro ID Name
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR028367  Cyclin C/cyclin-like subunit Ssn8
 IPR031658  Cyclin, C-terminal domain 2
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain IBA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016592 mediator complex IEA
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA


Pathways (from Reactome)
Pathway description
Generic Transcription Pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001715 placental labyrinth hypoplasia "reduction in cell number of the placental labyrinth, the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Hprttm2(CAG-Ppp1r3c)Jjg/?,Nhlrc1tm1(KOMP)Vlcg/Nhlrc1tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hprttm2(CAG-Ppp1r3c)Jjg/?,Nhlrc1tm1(KOMP)Vlcg/Nhlrc1tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Hprttm2(CAG-Ppp1r3c)Jjg/?,Nhlrc1tm1(KOMP)Vlcg/Nhlrc1tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hprttm2(CAG-Ppp1r3c)Jjg/?,Nhlrc1tm1(KOMP)Vlcg/Nhlrc1tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hprttm2(CAG-Ppp1r3c)Jjg/?,Nhlrc1tm1(KOMP)Vlcg/Nhlrc1tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029635 Cdk8 / Q8R3L8 / Cyclin-dependent kinase 8 / P49336*  / complex
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / reaction
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / reaction
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / reaction






 

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