ENSMUSG00000026349


Mus musculus

Features
Gene ID: ENSMUSG00000026349
  
Biological name :Ccnt2
  
Synonyms : Ccnt2 / Cyclin-T2 / Q7TQK0
  
Possible biological names infered from orthology : O60583
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E3
Gene start: 127774164
Gene end: 127808061
  
Corresponding Affymetrix probe sets: 10349442 (MoGene1.0st)   1427088_at (Mouse Genome 430 2.0 Array)   1427089_at (Mouse Genome 430 2.0 Array)   1435445_at (Mouse Genome 430 2.0 Array)   1452297_at (Mouse Genome 430 2.0 Array)   1453399_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027587
Ensembl peptide - ENSMUSP00000108189
NCBI entrez gene - 72949     See in Manteia.
MGI - MGI:1920199
RefSeq - NM_028399
RefSeq Peptide - NP_082675
swissprot - Q7TQK0
Ensembl - ENSMUSG00000026349
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccnt2aENSDARG00000036685Danio rerio
 CCNT2ENSGALG00000012207Gallus gallus
 CCNT2ENSG00000082258Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccnt1 / Q9QWV9 / Cyclin-T1 / O60563*ENSMUSG0000001196047
Ccnk / cyclin K / O75909*ENSMUSG0000002125818
Ccnl2 / Q9JJA7 / Cyclin-L2 / Q96S94*ENSMUSG0000002906816
Ccnl1 / Q52KE7 / Mus musculus cyclin L1 (Ccnl1), transcript variant 2, mRNA. / Q9UK58* / cyclin L1*ENSMUSG0000002782916
Ccnc / Q62447 / Cyclin-C / P24863*ENSMUSG0000002825210
Fam58b / Q8QZR8 / family with sequence similarity 58, member B / CCNQ* / Q8N1B3* / cyclin Q*ENSMUSG000000494897


Protein motifs (from Interpro)
Interpro ID Name
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR028862  Cyclin-T2
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007519 skeletal muscle tissue development IDA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019085 early viral transcription ISO
 biological_processGO:0019086 late viral transcription ISO
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0051147 regulation of muscle cell differentiation ISO
 biological_processGO:0051301 cell division IEA
 biological_processGO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain IBA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0008024 cyclin/CDK positive transcription elongation factor complex ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001223 transcription coactivator binding ISO
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0070063 RNA polymerase binding ISO
 molecular_functionGO:0097322 7SK snRNA binding ISO


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Angptl3tm1Lex/Angptl3tm1Lex,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000009555 Cdk9 / Q99J95 / Cyclin-dependent kinase 9 / P50750*  / reaction / complex
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / reaction
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / reaction
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr