ENSMUSG00000021258


Mus musculus

Features
Gene ID: ENSMUSG00000021258
  
Biological name :Ccnk
  
Synonyms : Ccnk / cyclin K
  
Possible biological names infered from orthology : O75909
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: F1
Gene start: 108179579
Gene end: 108203359
  
Corresponding Affymetrix probe sets: 10398195 (MoGene1.0st)   1424830_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098616
Ensembl peptide - ENSMUSP00000152784
NCBI entrez gene - 12454     See in Manteia.
MGI - MGI:1276106
RefSeq - XM_006515445
RefSeq - NM_009832
RefSeq - XM_006515443
RefSeq - XM_006515444
RefSeq Peptide - NP_033962
swissprot - Q3U3M5
Ensembl - ENSMUSG00000021258
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccnkENSDARG00000034146Danio rerio
 CCNKENSGALG00000011138Gallus gallus
 CCNKENSG00000090061Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccnt1 / Q9QWV9 / Cyclin-T1 / O60563*ENSMUSG0000001196024
Ccnt2 / Q7TQK0 / Cyclin-T2 / O60583*ENSMUSG0000002634923
Ccnl2 / Q9JJA7 / Cyclin-L2 / Q96S94*ENSMUSG0000002906818
Ccnl1 / Q52KE7 / Mus musculus cyclin L1 (Ccnl1), transcript variant 2, mRNA. / Q9UK58* / cyclin L1*ENSMUSG0000002782916
Ccnc / Q62447 / Cyclin-C / P24863*ENSMUSG0000002825213
Fam58b / Q8QZR8 / family with sequence similarity 58, member B / CCNQ* / Q8N1B3* / cyclin Q*ENSMUSG0000004948910


Protein motifs (from Interpro)
Interpro ID Name
 IPR004367  Cyclin, C-terminal domain
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0044828 negative regulation by host of viral genome replication IEA
 biological_processGO:0071157 negative regulation of cell cycle arrest IEA
 biological_processGO:2001165 positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues IEA
 cellular_componentGO:0002944 cyclin K-CDK12 complex IEA
 cellular_componentGO:0002945 cyclin K-CDK13 complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Taar1tm1Mmil/Taar1tm1Mmil
Genetic Background: B6.129S2-Taar1tm1Mmil

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003119 Cdk12 / Q14AX6 / Cyclin-dependent kinase 12 / Q9NYV4*  / complex / reaction
 ENSMUSG00000009555 Cdk9 / Q99J95 / Cyclin-dependent kinase 9 / P50750*  / complex / reaction
 ENSMUSG00000041297 Cdk13 / Q69ZA1 / Cyclin-dependent kinase 13 / Q14004*  / reaction / complex
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / reaction
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / reaction






 

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