ENSMUSG00000003119


Mus musculus

Features
Gene ID: ENSMUSG00000003119
  
Biological name :Cdk12
  
Synonyms : Cdk12 / Cyclin-dependent kinase 12 / Q14AX6
  
Possible biological names infered from orthology : Q9NYV4
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 98203059
Gene end: 98278504
  
Corresponding Affymetrix probe sets: 10380840 (MoGene1.0st)   10380859 (MoGene1.0st)   1425555_at (Mouse Genome 430 2.0 Array)   1425556_at (Mouse Genome 430 2.0 Array)   1438831_at (Mouse Genome 430 2.0 Array)   1440858_at (Mouse Genome 430 2.0 Array)   1443294_at (Mouse Genome 430 2.0 Array)   1455567_at (Mouse Genome 430 2.0 Array)   1455964_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003203
Ensembl peptide - ENSMUSP00000103162
Ensembl peptide - ENSMUSP00000103163
NCBI entrez gene - 69131     See in Manteia.
MGI - MGI:1098802
RefSeq - XM_011249226
RefSeq - NM_001109626
RefSeq - NM_001109628
RefSeq - NM_026952
RefSeq - XM_006534108
RefSeq - XM_011249224
RefSeq - XM_011249225
RefSeq Peptide - NP_001103096
RefSeq Peptide - NP_001103098
RefSeq Peptide - NP_081228
swissprot - Q14AX6
Ensembl - ENSMUSG00000003119
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk12ENSDARG00000063726Danio rerio
 CDK12ENSGALG00000001731Gallus gallus
 CDK12ENSG00000167258Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdk13 / Q69ZA1 / Cyclin-dependent kinase 13 / Q14004*ENSMUSG0000004129742
Cdk9 / Q99J95 / Cyclin-dependent kinase 9 / P50750*ENSMUSG000000095558


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter IBA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008380 RNA splicing ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0043405 regulation of MAP kinase activity IEA
 biological_processGO:0043484 regulation of RNA splicing IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0070816 phosphorylation of RNA polymerase II C-terminal domain IEA
 biological_processGO:2000737 negative regulation of stem cell differentiation IMP
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0002944 cyclin K-CDK12 complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IBA
 cellular_componentGO:0008024 cyclin/CDK positive transcription elongation factor complex IBA
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISS
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IBA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IDA
 molecular_functionGO:0030332 cyclin binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA


Pathways (from Reactome)
Pathway description
TP53 Regulates Transcription of DNA Repair Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Xirp1tm1Jl/Xirp1+
Genetic Background: involves: 129

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Xirp1tm1Jl/Xirp1+
Genetic Background: involves: 129

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Xirp1tm1Jl/Xirp1+
Genetic Background: involves: 129

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Xirp1tm1Jl/Xirp1+
Genetic Background: involves: 129

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Xirp1tm1Jl/Xirp1+
Genetic Background: involves: 129

Allelic Composition: Cdk12tm1.1Mjfn/Cdk12tm1.2Mjfn,Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021258 Ccnk / cyclin K / O75909*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr