ENSGALG00000001731


Gallus gallus

Features
Gene ID: ENSGALG00000001731
  
Biological name :CDK12
  
Synonyms : CDK12 / cyclin dependent kinase 12
  
Possible biological names infered from orthology : Q14AX6 / Q9NYV4
  
Species: Gallus gallus
  
Chr. number: 27
Strand: 1
Band:
Gene start: 4573382
Gene end: 4599083
  
Corresponding Affymetrix probe sets: GgaAffx.1133.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000002654
Ensembl peptide - ENSGALP00000047556
NCBI entrez gene - 428306     See in Manteia.
RefSeq - XM_425866
RefSeq - XM_004948584
RefSeq - XM_004948585
RefSeq - XM_003642804
RefSeq - XM_004948582
RefSeq - XM_004948583
swissprot - E1BUG0
swissprot - A0A1D5P4E8
Ensembl - ENSGALG00000001731
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk12ENSDARG00000063726Danio rerio
 CDK12ENSG00000167258Homo sapiens
 Cdk12ENSMUSG00000003119Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDK13 / cyclin dependent kinase 13 / Q14004* / Q69ZA1*ENSGALG0000004324339
CDK9 / Q5ZKN1 / Cyclin-dependent kinase 9 / P50750* / Q99J95*ENSGALG000000355768


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0043405 regulation of MAP kinase activity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0070816 phosphorylation of RNA polymerase II C-terminal domain IBA
 biological_processGO:2000737 negative regulation of stem cell differentiation IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0002944 cyclin K-CDK12 complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IBA
 cellular_componentGO:0008024 cyclin/CDK positive transcription elongation factor complex IBA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IBA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IBA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030332 cyclin binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA


Pathways (from Reactome)
Pathway description
TP53 Regulates Transcription of DNA Repair Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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