ENSG00000167258


Homo sapiens

Features
Gene ID: ENSG00000167258
  
Biological name :CDK12
  
Synonyms : CDK12 / cyclin dependent kinase 12 / Q9NYV4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q12
Gene start: 39461511
Gene end: 39564907
  
Corresponding Affymetrix probe sets: 1556654_at (Human Genome U133 Plus 2.0 Array)   1556655_s_at (Human Genome U133 Plus 2.0 Array)   219226_at (Human Genome U133 Plus 2.0 Array)   225690_at (Human Genome U133 Plus 2.0 Array)   225691_at (Human Genome U133 Plus 2.0 Array)   225694_at (Human Genome U133 Plus 2.0 Array)   225697_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398880
Ensembl peptide - ENSP00000407720
Ensembl peptide - ENSP00000453329
Ensembl peptide - ENSP00000464641
NCBI entrez gene - 51755     See in Manteia.
OMIM - 615514
RefSeq - XM_017024753
RefSeq - XM_017024748
RefSeq - XM_017024749
RefSeq - XM_017024750
RefSeq - XM_017024751
RefSeq - XM_017024752
RefSeq - NM_015083
RefSeq - NM_016507
RefSeq - XM_005257456
RefSeq - XM_005257458
RefSeq - XM_011524892
RefSeq - XM_011524893
RefSeq - XM_011524894
RefSeq - XM_011524895
RefSeq - XM_011524896
RefSeq - XM_011524897
RefSeq - XM_011524898
RefSeq - XM_011524899
RefSeq - XM_011524900
RefSeq - XM_011524901
RefSeq - XM_011524902
RefSeq - XM_011524903
RefSeq - XM_011524905
RefSeq - XM_011524906
RefSeq - XM_011524907
RefSeq - XM_017024744
RefSeq - XM_017024745
RefSeq - XM_017024746
RefSeq - XM_017024747
RefSeq Peptide - NP_055898
RefSeq Peptide - NP_057591
swissprot - J3QSD7
swissprot - Q9NYV4
swissprot - H0YLT2
Ensembl - ENSG00000167258
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk12ENSDARG00000063726Danio rerio
 CDK12ENSGALG00000001731Gallus gallus
 Cdk12ENSMUSG00000003119Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDK13 / Q14004 / cyclin dependent kinase 13ENSG0000006588341
CDK9 / P50750 / cyclin dependent kinase 9ENSG000001368078


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter IBA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008380 RNA splicing ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0043405 regulation of MAP kinase activity IMP
 biological_processGO:0043484 regulation of RNA splicing IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0070816 phosphorylation of RNA polymerase II C-terminal domain IMP
 biological_processGO:2000737 negative regulation of stem cell differentiation IEA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0002944 cyclin K-CDK12 complex IPI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IBA
 cellular_componentGO:0008024 cyclin/CDK positive transcription elongation factor complex IBA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IBA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IMP
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030332 cyclin binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA


Pathways (from Reactome)
Pathway description
TP53 Regulates Transcription of DNA Repair Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000090061 CCNK / O75909 / cyclin K  / complex / reaction






 

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