ENSG00000090061


Homo sapiens

Features
Gene ID: ENSG00000090061
  
Biological name :CCNK
  
Synonyms : CCNK / cyclin K / O75909
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q32.2
Gene start: 99481169
Gene end: 99535044
  
Corresponding Affymetrix probe sets: 219273_at (Human Genome U133 Plus 2.0 Array)   225824_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452307
Ensembl peptide - ENSP00000374529
Ensembl peptide - ENSP00000450440
Ensembl peptide - ENSP00000450792
NCBI entrez gene - 8812     See in Manteia.
OMIM - 603544
RefSeq - XM_011537275
RefSeq - NM_001099402
RefSeq - XM_005268154
RefSeq Peptide - NP_001092872
swissprot - G3V5E1
swissprot - A0A024R6K1
swissprot - O75909
swissprot - G3V235
swissprot - G3V2Q3
Ensembl - ENSG00000090061
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccnkENSDARG00000034146Danio rerio
 CCNKENSGALG00000011138Gallus gallus
 CcnkENSMUSG00000021258Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCNT1 / O60563 / cyclin T1ENSG0000012931524
CCNT2 / O60583 / cyclin T2ENSG0000008225822
CCNL2 / Q96S94 / cyclin L2ENSG0000022197818
CCNL1 / Q9UK58 / cyclin L1ENSG0000016366017
CCNC / P24863 / cyclin CENSG0000011223713
CCNQ / Q8N1B3 / cyclin QENSG0000026291910


Protein motifs (from Interpro)
Interpro ID Name
 IPR004367  Cyclin, C-terminal domain
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0042795 snRNA transcription by RNA polymerase II TAS
 biological_processGO:0044828 negative regulation by host of viral genome replication IDA
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0071157 negative regulation of cell cycle arrest IGI
 biological_processGO:2001165 positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues IMP
 cellular_componentGO:0002944 cyclin K-CDK12 complex IPI
 cellular_componentGO:0002945 cyclin K-CDK13 complex IPI
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IDA
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of HIV elongation complex in the absence of HIV Tat
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000060069 CTDP1 / Q9Y5B0 / CTD phosphatase subunit 1  / reaction
 ENSG00000213246 P63272 / SUPT4H1 / SPT4 homolog, DSIF elongation factor subunit  / reaction
 ENSG00000185049 NELFA / Q9H3P2 / negative elongation factor complex member A  / reaction
 ENSG00000188986 NELFB / Q8WX92 / negative elongation factor complex member B  / reaction
 ENSG00000114503 NCBP2 / P52298 / nuclear cap binding protein subunit 2  / reaction
 ENSG00000196235 O00267 / SUPT5H / SPT5 homolog, DSIF elongation factor subunit  / reaction
 ENSG00000136937 NCBP1 / Q09161 / nuclear cap binding protein subunit 1  / reaction
 ENSG00000204356 NELFE / P18615 / negative elongation factor complex member E  / reaction
 ENSG00000136807 CDK9 / P50750 / cyclin dependent kinase 9  / complex / reaction
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / reaction
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / reaction
 ENSG00000065883 CDK13 / Q14004 / cyclin dependent kinase 13  / reaction / complex
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / reaction
 ENSG00000167258 CDK12 / Q9NYV4 / cyclin dependent kinase 12  / reaction / complex






 

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