ENSG00000213246


Homo sapiens

Features
Gene ID: ENSG00000213246
  
Biological name :SUPT4H1
  
Synonyms : P63272 / SPT4 homolog, DSIF elongation factor subunit / SUPT4H1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q22
Gene start: 58345175
Gene end: 58353093
  
Corresponding Affymetrix probe sets: 201483_s_at (Human Genome U133 Plus 2.0 Array)   201484_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000225504
Ensembl peptide - ENSP00000462670
Ensembl peptide - ENSP00000464618
Ensembl peptide - ENSP00000463979
Ensembl peptide - ENSP00000462100
Ensembl peptide - ENSP00000462602
NCBI entrez gene - 6827     See in Manteia.
OMIM - 603555
RefSeq - NM_003168
RefSeq Peptide - NP_003159
swissprot - J3QR04
swissprot - D3DTZ5
swissprot - P63272
swissprot - J3QSB9
swissprot - J3KSQ6
Ensembl - ENSG00000213246
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6DGQ0ENSDARG00000113969Danio rerio
 SUPT4H1ENSGALG00000000944Gallus gallus
 P63271ENSMUSG00000020485Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009287  Transcription initiation Spt4
 IPR022800  Spt4/RpoE2 zinc finger
 IPR029040  RNA polymerase subunit RPABC4/transcription elongation factor Spt4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006338 chromatin remodeling TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0006397 mRNA processing IBA
 biological_processGO:0032785 negative regulation of DNA-templated transcription, elongation IDA
 biological_processGO:0032786 positive regulation of DNA-templated transcription, elongation IDA
 biological_processGO:0034243 regulation of transcription elongation from RNA polymerase II promoter IBA
 biological_processGO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050434 positive regulation of viral transcription TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0032044 DSIF complex IDA
 molecular_functionGO:0000993 RNA polymerase II core binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003727 single-stranded RNA binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000060069 CTDP1 / Q9Y5B0 / CTD phosphatase subunit 1  / reaction / complex
 ENSG00000188986 NELFB / Q8WX92 / negative elongation factor complex member B  / reaction / complex
 ENSG00000185049 NELFA / Q9H3P2 / negative elongation factor complex member A  / reaction / complex
 ENSG00000090061 CCNK / O75909 / cyclin K  / reaction
 ENSG00000114503 NCBP2 / P52298 / nuclear cap binding protein subunit 2  / reaction / complex
 ENSG00000082258 CCNT2 / O60583 / cyclin T2  / reaction
 ENSG00000136937 NCBP1 / Q09161 / nuclear cap binding protein subunit 1  / complex / reaction
 ENSG00000129315 CCNT1 / O60563 / cyclin T1  / reaction
 ENSG00000204356 NELFE / P18615 / negative elongation factor complex member E  / reaction / complex
 ENSG00000136807 CDK9 / P50750 / cyclin dependent kinase 9  / reaction
 ENSG00000196235 O00267 / SUPT5H / SPT5 homolog, DSIF elongation factor subunit  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr