ENSG00000188986


Homo sapiens

Features
Gene ID: ENSG00000188986
  
Biological name :NELFB
  
Synonyms : negative elongation factor complex member B / NELFB / Q8WX92
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q34.3
Gene start: 137255173
Gene end: 137273546
  
Corresponding Affymetrix probe sets: 202757_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000339495
Ensembl peptide - ENSP00000489248
NCBI entrez gene - 25920     See in Manteia.
OMIM - 611180
RefSeq - NM_015456
RefSeq Peptide - NP_056271
swissprot - A0A0X1KG71
swissprot - Q8WX92
Ensembl - ENSG00000188986
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nelfbENSDARG00000035505Danio rerio
 NELFBENSGALG00000008532Gallus gallus
 NelfbENSMUSG00000013465Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR010405  Cofactor of BRCA1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IBA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0050434 positive regulation of viral transcription TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0032021 NELF complex IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA Polymerase II Transcription Elongation
NTRK3 as a dependence receptor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000060069 CTDP1 / Q9Y5B0 / CTD phosphatase subunit 1  / complex / reaction
 ENSG00000213246 P63272 / SUPT4H1 / SPT4 homolog, DSIF elongation factor subunit  / complex / reaction
 ENSG00000129315 CCNT1 / O60563 / cyclin T1  / reaction
 ENSG00000140538 NTRK3 / Q16288 / neurotrophic receptor tyrosine kinase 3  / reaction / complex
 ENSG00000082258 CCNT2 / O60583 / cyclin T2  / reaction
 ENSG00000185049 NELFA / Q9H3P2 / negative elongation factor complex member A  / reaction / complex
 ENSG00000204356 NELFE / P18615 / negative elongation factor complex member E  / complex / reaction
 ENSG00000136807 CDK9 / P50750 / cyclin dependent kinase 9  / reaction
 ENSG00000090061 CCNK / O75909 / cyclin K  / reaction
 ENSG00000114503 NCBP2 / P52298 / nuclear cap binding protein subunit 2  / reaction / complex
 ENSG00000196235 O00267 / SUPT5H / SPT5 homolog, DSIF elongation factor subunit  / complex / reaction
 ENSG00000136937 NCBP1 / Q09161 / nuclear cap binding protein subunit 1  / reaction / complex






 

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