ENSMUSG00000013465


Mus musculus

Features
Gene ID: ENSMUSG00000013465
  
Biological name :Nelfb
  
Synonyms : negative elongation factor B isoform 1 / Nelfb
  
Possible biological names infered from orthology : negative elongation factor complex member B / Q8WX92
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 25199712
Gene end: 25211489
  
Corresponding Affymetrix probe sets: 10480605 (MoGene1.0st)   1421292_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115296
Ensembl peptide - ENSMUSP00000057731
Ensembl peptide - ENSMUSP00000115698
NCBI entrez gene - 58202     See in Manteia.
MGI - MGI:1931035
RefSeq - NM_001310157
RefSeq - NM_021393
RefSeq Peptide - NP_067368
RefSeq Peptide - NP_001297086
swissprot - F6SWS9
swissprot - A0A0X1KG62
swissprot - F6UFF7
Ensembl - ENSMUSG00000013465
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nelfbENSDARG00000035505Danio rerio
 NELFBENSGALG00000008532Gallus gallus
 NELFBENSG00000188986Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR010405  Cofactor of BRCA1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Dsg4arm/Dsg4arm
Genetic Background: involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dsg4arm/Dsg4arm
Genetic Background: involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd

 MP:0004964 absent inner cell mass "absence of the cells of the blastocyst that develop into the body of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dsg4arm/Dsg4arm
Genetic Background: involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nelfbtm1.2Roli/Nelfbtm1.2Roli,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Nelfbtm1.2Roli/Nelfbtm1.2Roli,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Dsg4arm/Dsg4arm
Genetic Background: involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Dsg4arm/Dsg4arm
Genetic Background: involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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