ENSG00000082258


Homo sapiens

Features
Gene ID: ENSG00000082258
  
Biological name :CCNT2
  
Synonyms : CCNT2 / cyclin T2 / O60583
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q21.3
Gene start: 134918235
Gene end: 134959342
  
Corresponding Affymetrix probe sets: 204645_at (Human Genome U133 Plus 2.0 Array)   213743_at (Human Genome U133 Plus 2.0 Array)   214638_s_at (Human Genome U133 Plus 2.0 Array)   229184_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000404653
Ensembl peptide - ENSP00000402512
Ensembl peptide - ENSP00000415120
Ensembl peptide - ENSP00000264157
Ensembl peptide - ENSP00000295238
Ensembl peptide - ENSP00000387436
Ensembl peptide - ENSP00000399497
Ensembl peptide - ENSP00000400298
NCBI entrez gene - 905     See in Manteia.
OMIM - 603862
RefSeq - XM_017005232
RefSeq - NM_001241
RefSeq - NM_001320748
RefSeq - NM_001320749
RefSeq - NM_058241
RefSeq - XM_017005227
RefSeq - XM_017005228
RefSeq - XM_017005229
RefSeq - XM_017005230
RefSeq - XM_017005231
RefSeq Peptide - NP_001232
RefSeq Peptide - NP_001307678
RefSeq Peptide - NP_490595
RefSeq Peptide - NP_001307677
swissprot - H7C411
swissprot - O60583
swissprot - C9JUL2
swissprot - F2Z2C9
swissprot - F8WDY7
swissprot - H7BZ27
Ensembl - ENSG00000082258
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccnt2aENSDARG00000036685Danio rerio
 CCNT2ENSGALG00000012207Gallus gallus
 Ccnt2ENSMUSG00000026349Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCNT1 / O60563 / cyclin T1ENSG0000012931548
CCNK / O75909 / cyclin KENSG0000009006117
CCNL1 / Q9UK58 / cyclin L1ENSG0000016366016
CCNL2 / Q96S94 / cyclin L2ENSG0000022197816
CCNC / P24863 / cyclin CENSG0000011223710
CCNQ / Q8N1B3 / cyclin QENSG000002629197


Protein motifs (from Interpro)
Interpro ID Name
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR028862  Cyclin-T2
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007519 skeletal muscle tissue development IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019085 early viral transcription IDA
 biological_processGO:0019086 late viral transcription IDA
 biological_processGO:0042795 snRNA transcription by RNA polymerase II TAS
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0008024 cyclin/CDK positive transcription elongation factor complex IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001223 transcription coactivator binding IPI
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA
 molecular_functionGO:0070063 RNA polymerase binding IPI
 molecular_functionGO:0097322 7SK snRNA binding IDA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of HIV elongation complex in the absence of HIV Tat
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000060069 CTDP1 / Q9Y5B0 / CTD phosphatase subunit 1  / reaction
 ENSG00000213246 P63272 / SUPT4H1 / SPT4 homolog, DSIF elongation factor subunit  / reaction
 ENSG00000136807 CDK9 / P50750 / cyclin dependent kinase 9  / complex / reaction
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / reaction
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / reaction
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / reaction
 ENSG00000185049 NELFA / Q9H3P2 / negative elongation factor complex member A  / reaction
 ENSG00000188986 NELFB / Q8WX92 / negative elongation factor complex member B  / reaction
 ENSG00000114503 NCBP2 / P52298 / nuclear cap binding protein subunit 2  / reaction
 ENSG00000196235 O00267 / SUPT5H / SPT5 homolog, DSIF elongation factor subunit  / reaction
 ENSG00000136937 NCBP1 / Q09161 / nuclear cap binding protein subunit 1  / reaction
 ENSG00000204356 NELFE / P18615 / negative elongation factor complex member E  / reaction






 

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