ENSG00000112237


Homo sapiens

Features
Gene ID: ENSG00000112237
  
Biological name :CCNC
  
Synonyms : CCNC / cyclin C / P24863
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q16.2
Gene start: 99542380
Gene end: 99568973
  
Corresponding Affymetrix probe sets: 1569126_at (Human Genome U133 Plus 2.0 Array)   201955_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430014
Ensembl peptide - ENSP00000430077
Ensembl peptide - ENSP00000487040
Ensembl peptide - ENSP00000430718
Ensembl peptide - ENSP00000430381
Ensembl peptide - ENSP00000430294
Ensembl peptide - ENSP00000430119
Ensembl peptide - ENSP00000319027
Ensembl peptide - ENSP00000358222
Ensembl peptide - ENSP00000417072
Ensembl peptide - ENSP00000427885
Ensembl peptide - ENSP00000428472
Ensembl peptide - ENSP00000428577
Ensembl peptide - ENSP00000428982
NCBI entrez gene - 892     See in Manteia.
OMIM - 123838
RefSeq - XM_017011436
RefSeq - NM_001013399
RefSeq - NM_005190
RefSeq - XM_006715594
RefSeq - XM_011536232
RefSeq Peptide - NP_001013417
RefSeq Peptide - NP_005181
swissprot - J3KP90
swissprot - Q7Z4L3
swissprot - E5RIH8
swissprot - P24863
swissprot - Q5JV82
swissprot - E5RI39
swissprot - E5RHL8
swissprot - E5RFX8
swissprot - G5E954
swissprot - E5RFK5
swissprot - H0YBQ5
Ensembl - ENSG00000112237
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccncENSDARG00000009607Danio rerio
 CCNCENSGALG00000015471Gallus gallus
 CcncENSMUSG00000028252Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCNK / O75909 / cyclin KENSG0000009006128
CCNL1 / Q9UK58 / cyclin L1ENSG0000016366026
CCNT2 / O60583 / cyclin T2ENSG0000008225825
CCNL2 / Q96S94 / cyclin L2ENSG0000022197824
CCNT1 / O60563 / cyclin T1ENSG0000012931522
CCNQ / Q8N1B3 / cyclin QENSG0000026291917


Protein motifs (from Interpro)
Interpro ID Name
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR028367  Cyclin C/cyclin-like subunit Ssn8
 IPR031658  Cyclin, C-terminal domain 2
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain IBA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016592 mediator complex IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Generic Transcription Pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Transcriptional regulation of white adipocyte differentiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000114166 KAT2B / Q92831 / lysine acetyltransferase 2B  / reaction / complex
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / reaction
 ENSG00000184384 MAML2 / Q8IZL2 / mastermind like transcriptional coactivator 2  / complex / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / complex / reaction
 ENSG00000161021 MAML1 / Q92585 / mastermind like transcriptional coactivator 1  / reaction / complex
 ENSG00000196782 MAML3 / Q96JK9 / mastermind like transcriptional coactivator 3  / reaction / complex
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / reaction
 ENSG00000100603 SNW1 / Q13573 / SNW domain containing 1  / complex / reaction
 ENSG00000168214 RBPJ / Q06330 / recombination signal binding protein for immunoglobulin kappa J region  / complex / reaction
 ENSG00000132964 CDK8 / P49336 / cyclin dependent kinase 8  / complex
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / reaction






 

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