ENSG00000132964


Homo sapiens

Features
Gene ID: ENSG00000132964
  
Biological name :CDK8
  
Synonyms : CDK8 / cyclin dependent kinase 8 / P49336
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q12.13
Gene start: 26254104
Gene end: 26405238
  
Corresponding Affymetrix probe sets: 1553112_s_at (Human Genome U133 Plus 2.0 Array)   1553113_s_at (Human Genome U133 Plus 2.0 Array)   204831_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000485883
Ensembl peptide - ENSP00000487013
Ensembl peptide - ENSP00000370938
Ensembl peptide - ENSP00000437696
NCBI entrez gene - 1024     See in Manteia.
OMIM - 603184
RefSeq - XM_017020318
RefSeq - NM_001260
RefSeq - NM_001318368
RefSeq - NM_001346501
RefSeq - XM_005266216
RefSeq - XM_011534864
RefSeq - XM_011534865
RefSeq - XM_017020317
RefSeq Peptide - NP_001333430
RefSeq Peptide - NP_001251
RefSeq Peptide - NP_001305297
swissprot - A0A0D9SEP3
swissprot - P49336
swissprot - F5H6D4
swissprot - A0A0D9SFZ2
Ensembl - ENSG00000132964
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk8ENSDARG00000016496Danio rerio
 CDK8ENSGALG00000017104Gallus gallus
 Cdk8ENSMUSG00000029635Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDK19 / Q9BWU1 / cyclin dependent kinase 19ENSG0000015511183


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0016592 mediator complex IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Generic Transcription Pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Transcriptional regulation of white adipocyte differentiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112237 CCNC / P24863 / cyclin C  / complex
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / reaction
 ENSG00000196782 MAML3 / Q96JK9 / mastermind like transcriptional coactivator 3  / complex / reaction
 ENSG00000100603 SNW1 / Q13573 / SNW domain containing 1  / complex / reaction
 ENSG00000168214 RBPJ / Q06330 / recombination signal binding protein for immunoglobulin kappa J region  / complex / reaction
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / reaction
 ENSG00000114166 KAT2B / Q92831 / lysine acetyltransferase 2B  / reaction / complex
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / reaction
 ENSG00000184384 MAML2 / Q8IZL2 / mastermind like transcriptional coactivator 2  / complex / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / complex / reaction
 ENSG00000161021 MAML1 / Q92585 / mastermind like transcriptional coactivator 1  / reaction / complex






 

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