ENSG00000114166


Homo sapiens

Features
Gene ID: ENSG00000114166
  
Biological name :KAT2B
  
Synonyms : KAT2B / lysine acetyltransferase 2B / Q92831
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p24.3
Gene start: 20040023
Gene end: 20154404
  
Corresponding Affymetrix probe sets: 203845_at (Human Genome U133 Plus 2.0 Array)   239585_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263754
NCBI entrez gene - 8850     See in Manteia.
OMIM - 602303
RefSeq - XM_017007424
RefSeq - NM_003884
RefSeq - XM_005265528
RefSeq - XM_017007423
RefSeq Peptide - NP_003875
swissprot - Q92831
Ensembl - ENSG00000114166
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Kat2bENSMUSG00000000708Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KAT2A / Q92830 / lysine acetyltransferase 2AENSG0000010877371
BPTF / Q12830 / bromodomain PHD finger transcription factorENSG0000017163428
CECR2 / Q9BXF3 / CECR2, histone acetyl-lysine readerENSG0000009995413


Protein motifs (from Interpro)
Interpro ID Name
 IPR000182  GNAT domain
 IPR001487  Bromodomain
 IPR009464  PCAF, N-terminal
 IPR016181  Acyl-CoA N-acyltransferase
 IPR016376  Histone acetyltransferase GCN5/PCAF
 IPR018359  Bromodomain, conserved site
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006338 chromatin remodeling TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006473 protein acetylation TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0007219 Notch signaling pathway TAS
 biological_processGO:0007221 positive regulation of transcription of Notch receptor target TAS
 biological_processGO:0007507 heart development ISS
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0010835 regulation of protein ADP-ribosylation IDA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0018076 N-terminal peptidyl-lysine acetylation IDA
 biological_processGO:0018393 internal peptidyl-lysine acetylation IEA
 biological_processGO:0018394 peptidyl-lysine acetylation IDA
 biological_processGO:0032869 cellular response to insulin stimulus IDA
 biological_processGO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IEA
 biological_processGO:0043966 histone H3 acetylation IDA
 biological_processGO:0043970 histone H3-K9 acetylation IEA
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045747 positive regulation of Notch signaling pathway TAS
 biological_processGO:0045815 positive regulation of gene expression, epigenetic TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046600 negative regulation of centriole replication IDA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0060173 limb development ISS
 cellular_componentGO:0000123 histone acetyltransferase complex IEA
 cellular_componentGO:0000125 PCAF complex NAS
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0031672 A band IEA
 cellular_componentGO:0031674 I band IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0042641 actomyosin IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003712 transcription coregulator activity IPI
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0004402 histone acetyltransferase activity IMP
 molecular_functionGO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IEA
 molecular_functionGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008080 N-acetyltransferase activity IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016407 acetyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0044877 protein-containing complex binding IDA
 molecular_functionGO:0061733 peptide-lysine-N-acetyltransferase activity IDA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HATs acetylate histones
Notch-HLH transcription pathway
B-WICH complex positively regulates rRNA expression
Physiological factors
Metalloprotease DUBs
RNA Polymerase I Transcription Initiation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108773 KAT2A / Q92830 / lysine acetyltransferase 2A  / complex / reaction
 ENSG00000100603 SNW1 / Q13573 / SNW domain containing 1  / complex
 ENSG00000089225 TBX5 / Q99593 / T-box 5  / reaction / complex
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction
 ENSG00000162601 MYSM1 / Q5VVJ2 / Myb like, SWIRM and MPN domains 1  / complex
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction / complex
 ENSG00000161021 MAML1 / Q92585 / mastermind like transcriptional coactivator 1  / complex
 ENSG00000168214 RBPJ / Q06330 / recombination signal binding protein for immunoglobulin kappa J region  / complex
 ENSG00000112237 CCNC / P24863 / cyclin C  / complex / reaction
 ENSG00000018408 WWTR1 / Q9GZV5 / WW domain containing transcription regulator 1  / complex / reaction
 ENSG00000132964 CDK8 / P49336 / cyclin dependent kinase 8  / complex / reaction
 ENSG00000196782 MAML3 / Q96JK9 / mastermind like transcriptional coactivator 3  / complex
 ENSG00000184384 MAML2 / Q8IZL2 / mastermind like transcriptional coactivator 2  / complex






 

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