ENSG00000018408


Homo sapiens

Features
Gene ID: ENSG00000018408
  
Biological name :WWTR1
  
Synonyms : Q9GZV5 / WW domain containing transcription regulator 1 / WWTR1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q25.1
Gene start: 149517235
Gene end: 149736714
  
Corresponding Affymetrix probe sets: 202132_at (Human Genome U133 Plus 2.0 Array)   202133_at (Human Genome U133 Plus 2.0 Array)   202134_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417984
Ensembl peptide - ENSP00000420159
Ensembl peptide - ENSP00000420120
Ensembl peptide - ENSP00000419465
Ensembl peptide - ENSP00000419234
Ensembl peptide - ENSP00000418621
Ensembl peptide - ENSP00000418580
Ensembl peptide - ENSP00000353847
Ensembl peptide - ENSP00000417339
Ensembl peptide - ENSP00000417862
NCBI entrez gene - 25937     See in Manteia.
OMIM - 607392
RefSeq - XM_017006122
RefSeq - NM_001168278
RefSeq - NM_001168280
RefSeq - NM_001348362
RefSeq - NM_015472
RefSeq - XM_017006121
RefSeq Peptide - NP_056287
RefSeq Peptide - NP_001161750
RefSeq Peptide - NP_001161752
RefSeq Peptide - NP_001335291
swissprot - C9J337
swissprot - C9J038
swissprot - C9JQS8
swissprot - H7C4Z7
swissprot - H7C4Q0
swissprot - Q9GZV5
swissprot - C9JR84
swissprot - C9J588
Ensembl - ENSG00000018408
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wwtr1ENSDARG00000067719Danio rerio
 WWTR1ENSGALG00000010412Gallus gallus
 Wwtr1ENSMUSG00000027803Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
YAP1 / P46937 / Yes associated protein 1ENSG0000013769351


Protein motifs (from Interpro)
Interpro ID Name
 IPR001202  WW domain
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006469 negative regulation of protein kinase activity IMP
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0017145 stem cell division IDA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032835 glomerulus development IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0035329 hippo signaling TAS
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0048762 mesenchymal cell differentiation IEA
 biological_processGO:0060271 cilium assembly IEA
 biological_processGO:0060390 regulation of SMAD protein signal transduction IDA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0060993 kidney morphogenesis IEA
 biological_processGO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0003713 transcription coactivator activity NAS
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Signaling by Hippo
YAP1- and WWTR1 (TAZ)-stimulated gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Physiological factors
RUNX2 regulates osteoblast differentiation
RUNX3 regulates YAP1-mediated transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000114019 AMOTL2 / Q9Y2J4 / angiomotin like 2  / reaction / complex
 ENSG00000131023 LATS1 / O95835 / large tumor suppressor kinase 1  / reaction
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / complex / reaction
 ENSG00000074219 TEAD2 / Q15562 / TEA domain transcription factor 2  / reaction / complex
 ENSG00000126016 AMOT / Q4VCS5 / angiomotin  / reaction / complex
 ENSG00000166025 AMOTL1 / Q8IY63 / angiomotin like 1  / complex / reaction
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / complex / reaction
 ENSG00000007866 TEAD3 / Q99594 / TEA domain transcription factor 3  / reaction / complex
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / complex / reaction
 ENSG00000187079 TEAD1 / P28347 / TEA domain transcription factor 1  / reaction / complex
 ENSG00000119139 TJP2 / Q9UDY2 / tight junction protein 2  / reaction / complex
 ENSG00000104067 TJP1 / Q07157 / tight junction protein 1  / complex / reaction
 ENSG00000124813 RUNX2 / Q13950 / runt related transcription factor 2  / complex / reaction
 ENSG00000197905 TEAD4 / Q15561 / TEA domain transcription factor 4  / complex / reaction
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / complex / reaction
 ENSG00000089225 TBX5 / Q99593 / T-box 5  / complex / reaction
 ENSG00000114166 KAT2B / Q92831 / lysine acetyltransferase 2B  / reaction / complex
 ENSG00000108953 YWHAE / P62258 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon  / reaction / complex
 ENSG00000150457 LATS2 / Q9NRM7 / large tumor suppressor kinase 2  / reaction






 

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