ENSG00000104067


Homo sapiens

Features
Gene ID: ENSG00000104067
  
Biological name :TJP1
  
Synonyms : Q07157 / tight junction protein 1 / TJP1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q13.1
Gene start: 29699367
Gene end: 29968865
  
Corresponding Affymetrix probe sets: 202011_at (Human Genome U133 Plus 2.0 Array)   214168_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453334
Ensembl peptide - ENSP00000452729
Ensembl peptide - ENSP00000483470
Ensembl peptide - ENSP00000281537
Ensembl peptide - ENSP00000348416
Ensembl peptide - ENSP00000382887
Ensembl peptide - ENSP00000382890
Ensembl peptide - ENSP00000441202
NCBI entrez gene - 7082     See in Manteia.
OMIM - 601009
RefSeq - XM_017022531
RefSeq - XM_005254617
RefSeq - XM_005254618
RefSeq - XM_005254619
RefSeq - XM_005254620
RefSeq - XM_011521972
RefSeq - XM_017022521
RefSeq - XM_017022522
RefSeq - XM_017022523
RefSeq - XM_017022524
RefSeq - XM_017022525
RefSeq - XM_017022526
RefSeq - XM_017022527
RefSeq - XM_017022528
RefSeq - XM_017022529
RefSeq - XM_017022530
RefSeq - NM_001301025
RefSeq - NM_001301026
RefSeq - NM_001355012
RefSeq - NM_001355013
RefSeq - NM_001355014
RefSeq - NM_003257
RefSeq - NM_175610
RefSeq Peptide - NP_001317168
RefSeq Peptide - NP_001341941
RefSeq Peptide - NP_001341942
RefSeq Peptide - NP_001341943
RefSeq Peptide - NP_003248
RefSeq Peptide - NP_783297
RefSeq Peptide - NP_001287954
RefSeq Peptide - NP_001287955
swissprot - G5E9E7
swissprot - H0Y3R8
swissprot - H0YKB1
swissprot - H0YLT6
swissprot - A0A087X0K9
swissprot - G3V1L9
swissprot - Q07157
Ensembl - ENSG00000104067
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tjp1aENSDARG00000077506Danio rerio
 tjp1bENSDARG00000079374Danio rerio
 TJP1ENSGALG00000042552Gallus gallus
 Tjp1ENSMUSG00000030516Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AL358113.1ENSG0000028513032
TJP2 / Q9UDY2 / tight junction protein 2ENSG0000011913932
TJP3 / O95049 / tight junction protein 3ENSG0000010528924
DLG5 / Q8TDM6 / discs large MAGUK scaffold protein 5ENSG0000015120812
DLG4 / P78352 / discs large MAGUK scaffold protein 4ENSG000001325359
DLG1 / Q12959 / discs large MAGUK scaffold protein 1ENSG000000757119
DLG2 / Q15700 / discs large MAGUK scaffold protein 2ENSG000001506729
DLG3 / Q92796 / discs large MAGUK scaffold protein 3ENSG000000824589
MPP2 / Q14168 / membrane palmitoylated protein 2ENSG000001088526
MPP7 / Q5T2T1 / membrane palmitoylated protein 7ENSG000001500546
MPP4 / Q96JB8 / membrane palmitoylated protein 4ENSG000000821266
CASK / O14936 / calcium/calmodulin dependent serine protein kinaseENSG000001470446
MPP5 / Q8N3R9 / membrane palmitoylated protein 5ENSG000000724156
MPP3 / Q13368 / membrane palmitoylated protein 3ENSG000001616476
MPP6 / Q9NZW5 / membrane palmitoylated protein 6ENSG000001059265
MPP1 / Q00013 / membrane palmitoylated protein 1ENSG000001308305
GUK1 / Q16774 / guanylate kinase 1ENSG000001437742


Protein motifs (from Interpro)
Interpro ID Name
 IPR000906  ZU5 domain
 IPR001452  SH3 domain
 IPR001478  PDZ domain
 IPR005417  Tight junction protein ZO
 IPR005418  Tight junction protein ZO-1
 IPR008144  Guanylate kinase-like domain
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035597  ZO-1, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001825 blastocyst formation IEA
 biological_processGO:0007043 cell-cell junction assembly TAS
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0035329 hippo signaling TAS
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043116 negative regulation of vascular permeability IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0071000 response to magnetism IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0090557 establishment of endothelial intestinal barrier IMP
 biological_processGO:1901350 cell-cell signaling involved in cell-cell junction organization NAS
 biological_processGO:2000810 regulation of bicellular tight junction assembly TAS
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005913 cell-cell adherens junction TAS
 cellular_componentGO:0005921 gap junction IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0014704 intercalated disc IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016327 apicolateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043296 apical junction complex IDA
 cellular_componentGO:0045177 apical part of cell IDA
 cellular_componentGO:0046581 intercellular canaliculus IEA
 cellular_componentGO:0070160 occluding junction IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0071253 connexin binding IEA


Pathways (from Reactome)
Pathway description
c-src mediated regulation of Cx43 function and closure of gap junctions
Signaling by Hippo
Apoptotic cleavage of cell adhesion proteins
RUNX1 regulates expression of components of tight junctions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164305 CASP3 / P42574 / caspase 3  / reaction
 ENSG00000152661 GJA1 / P17302 / gap junction protein alpha 1  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000018408 WWTR1 / Q9GZV5 / WW domain containing transcription regulator 1  / reaction / complex
 ENSG00000104067 TJP1 / Q07157 / tight junction protein 1  / complex






 

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