ENSG00000151208


Homo sapiens

Features
Gene ID: ENSG00000151208
  
Biological name :DLG5
  
Synonyms : discs large MAGUK scaffold protein 5 / DLG5 / Q8TDM6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q22.3
Gene start: 77790791
Gene end: 77926526
  
Corresponding Affymetrix probe sets: 201681_s_at (Human Genome U133 Plus 2.0 Array)   210469_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000473298
Ensembl peptide - ENSP00000361467
Ensembl peptide - ENSP00000394797
NCBI entrez gene - 9231     See in Manteia.
OMIM - 604090
RefSeq - XM_017016915
RefSeq - NM_004747
RefSeq - XM_011540346
RefSeq - XM_011540347
RefSeq - XM_017016913
RefSeq - XM_017016914
RefSeq - XM_005270276
RefSeq - XM_006718056
RefSeq - XM_006718057
RefSeq - XM_011540341
RefSeq - XM_011540342
RefSeq - XM_011540344
RefSeq - XM_011540345
RefSeq Peptide - NP_004738
swissprot - Q8TDM6
swissprot - R4GMQ2
swissprot - A0A0A0MSL1
Ensembl - ENSG00000151208
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dlg5aENSDARG00000074059Danio rerio
 dlg5b.1ENSDARG00000090949Danio rerio
 DLG5ENSGALG00000043018Gallus gallus
 Dlg5ENSMUSG00000021782Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TJP2 / Q9UDY2 / tight junction protein 2ENSG0000011913911
DLG1 / Q12959 / discs large MAGUK scaffold protein 1ENSG0000007571111
TJP1 / Q07157 / tight junction protein 1ENSG0000010406711
AL358113.1ENSG0000028513011
DLG2 / Q15700 / discs large MAGUK scaffold protein 2ENSG0000015067210
DLG3 / Q92796 / discs large MAGUK scaffold protein 3ENSG0000008245810
DLG4 / P78352 / discs large MAGUK scaffold protein 4ENSG0000013253510
TJP3 / O95049 / tight junction protein 3ENSG0000010528910
CASK / O14936 / calcium/calmodulin dependent serine protein kinaseENSG000001470447
MPP7 / Q5T2T1 / membrane palmitoylated protein 7ENSG000001500547
MPP3 / Q13368 / membrane palmitoylated protein 3ENSG000001616476
MPP5 / Q8N3R9 / membrane palmitoylated protein 5ENSG000000724156
MPP4 / Q96JB8 / membrane palmitoylated protein 4ENSG000000821266
MPP2 / Q14168 / membrane palmitoylated protein 2ENSG000001088525
MPP6 / Q9NZW5 / membrane palmitoylated protein 6ENSG000001059265
MPP1 / Q00013 / membrane palmitoylated protein 1ENSG000001308304
GUK1 / Q16774 / guanylate kinase 1ENSG000001437742


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR001452  SH3 domain
 IPR001478  PDZ domain
 IPR006907  Domain of unknown function DUF622
 IPR008144  Guanylate kinase-like domain
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR011029  Death-like domain superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035537  Disks large homologue 5, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001837 epithelial to mesenchymal transition IMP
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0030011 maintenance of cell polarity IMP
 biological_processGO:0030336 negative regulation of cell migration IMP
 biological_processGO:0030859 polarized epithelial cell differentiation IEA
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0035331 negative regulation of hippo signaling IEA
 biological_processGO:0035332 positive regulation of hippo signaling IMP
 biological_processGO:0035556 intracellular signal transduction NAS
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0045176 apical protein localization IEA
 biological_processGO:0045186 zonula adherens assembly IEA
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IEA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IEA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IEA
 biological_processGO:0060999 positive regulation of dendritic spine development IEA
 biological_processGO:0071896 protein localization to adherens junction IEA
 biological_processGO:0072205 metanephric collecting duct development IEA
 biological_processGO:0098609 cell-cell adhesion NAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0036064 ciliary basal body IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IDA
 molecular_functionGO:0008092 cytoskeletal protein binding IDA
 molecular_functionGO:0030159 receptor signaling complex scaffold activity NAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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