ENSG00000072415


Homo sapiens

Features
Gene ID: ENSG00000072415
  
Biological name :MPP5
  
Synonyms : membrane palmitoylated protein 5 / MPP5 / Q8N3R9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q23.3
Gene start: 67241109
Gene end: 67335819
  
Corresponding Affymetrix probe sets: 219321_at (Human Genome U133 Plus 2.0 Array)   226092_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450550
Ensembl peptide - ENSP00000451488
Ensembl peptide - ENSP00000451571
Ensembl peptide - ENSP00000261681
Ensembl peptide - ENSP00000450656
NCBI entrez gene - 64398     See in Manteia.
OMIM - 606958
RefSeq - XM_011537087
RefSeq - NM_001256550
RefSeq - NM_022474
RefSeq - XM_005268003
RefSeq - XM_011537086
RefSeq Peptide - NP_071919
RefSeq Peptide - NP_001243479
swissprot - G3V2H1
swissprot - Q8N3R9
swissprot - G3V2B0
Ensembl - ENSG00000072415
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mpp5aENSDARG00000006272Danio rerio
 mpp5bENSDARG00000004721Danio rerio
 MPP5ENSGALG00000009581Gallus gallus
 Mpp5ENSMUSG00000021112Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MPP7 / Q5T2T1 / membrane palmitoylated protein 7ENSG0000015005432
MPP4 / Q96JB8 / membrane palmitoylated protein 4ENSG0000008212629
MPP3 / Q13368 / membrane palmitoylated protein 3ENSG0000016164729
MPP2 / Q14168 / membrane palmitoylated protein 2ENSG0000010885227
MPP6 / Q9NZW5 / membrane palmitoylated protein 6ENSG0000010592627
DLG3 / Q92796 / discs large MAGUK scaffold protein 3ENSG0000008245825
DLG2 / Q15700 / discs large MAGUK scaffold protein 2ENSG0000015067225
DLG1 / Q12959 / discs large MAGUK scaffold protein 1ENSG0000007571124
CASK / O14936 / calcium/calmodulin dependent serine protein kinaseENSG0000014704424
DLG4 / P78352 / discs large MAGUK scaffold protein 4ENSG0000013253523
MPP1 / Q00013 / membrane palmitoylated protein 1ENSG0000013083020
DLG5 / Q8TDM6 / discs large MAGUK scaffold protein 5ENSG0000015120817
AL358113.1ENSG0000028513017
TJP1 / Q07157 / tight junction protein 1ENSG0000010406716
TJP2 / Q9UDY2 / tight junction protein 2ENSG0000011913916
TJP3 / O95049 / tight junction protein 3ENSG0000010528915
GUK1 / Q16774 / guanylate kinase 1ENSG0000014377410


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001478  PDZ domain
 IPR004172  L27 domain
 IPR008144  Guanylate kinase-like domain
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR014775  L27 domain, C-terminal
 IPR015145  L27-N
 IPR020590  Guanylate kinase, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031185  MAGUK p55 subfamily member 5
 IPR035601  MPP5, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036034  PDZ superfamily
 IPR036892  L27 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002011 morphogenesis of an epithelial sheet IMP
 biological_processGO:0007009 plasma membrane organization IEA
 biological_processGO:0032287 peripheral nervous system myelin maintenance IEA
 biological_processGO:0032288 myelin assembly IEA
 biological_processGO:0035750 protein localization to myelin sheath abaxonal region IEA
 biological_processGO:0070830 bicellular tight junction assembly IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0090162 establishment of epithelial cell polarity IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0035749 myelin sheath adaxonal region IEA
 cellular_componentGO:0043219 lateral loop IEA
 cellular_componentGO:0043220 Schmidt-Lanterman incisure IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019904 protein domain specific binding IPI


Pathways (from Reactome)
Pathway description
Tight junction interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132849 PATJ / Q8NI35 / PATJ, crumbs cell polarity complex component  / reaction / complex
 ENSG00000130545 CRB3 / Q9BUF7 / crumbs 3, cell polarity complex component  / reaction / complex






 

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