ENSG00000108852


Homo sapiens

Features
Gene ID: ENSG00000108852
  
Biological name :MPP2
  
Synonyms : membrane palmitoylated protein 2 / MPP2 / Q14168
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.31
Gene start: 43875357
Gene end: 43909711
  
Corresponding Affymetrix probe sets: 207984_s_at (Human Genome U133 Plus 2.0 Array)   213270_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428182
Ensembl peptide - ENSP00000428136
Ensembl peptide - ENSP00000428218
Ensembl peptide - ENSP00000486553
Ensembl peptide - ENSP00000483278
Ensembl peptide - ENSP00000480071
Ensembl peptide - ENSP00000479767
Ensembl peptide - ENSP00000478528
Ensembl peptide - ENSP00000438012
Ensembl peptide - ENSP00000430797
Ensembl peptide - ENSP00000430540
Ensembl peptide - ENSP00000430443
Ensembl peptide - ENSP00000430349
Ensembl peptide - ENSP00000429364
Ensembl peptide - ENSP00000428938
Ensembl peptide - ENSP00000428468
Ensembl peptide - ENSP00000428354
Ensembl peptide - ENSP00000428286
Ensembl peptide - ENSP00000269095
Ensembl peptide - ENSP00000366389
NCBI entrez gene - 4355     See in Manteia.
OMIM - 600723
RefSeq - NM_001278375
RefSeq - NM_001278370
RefSeq - NM_001278371
RefSeq - NM_001278372
RefSeq - NM_001278373
RefSeq - NM_001278374
RefSeq - NM_001278376
RefSeq - NM_001278381
RefSeq - NM_005374
RefSeq - XM_011524827
RefSeq Peptide - NP_001265303
RefSeq Peptide - NP_001265304
RefSeq Peptide - NP_001265305
RefSeq Peptide - NP_001265301
RefSeq Peptide - NP_001265310
RefSeq Peptide - NP_005365
RefSeq Peptide - NP_001265302
RefSeq Peptide - NP_001265299
RefSeq Peptide - NP_001265300
swissprot - E5RK44
swissprot - E5RJK0
swissprot - E5RIU3
swissprot - E5RIM9
swissprot - E5RI47
swissprot - E5RI32
swissprot - E5RFN8
swissprot - D3DX48
swissprot - D3DX49
swissprot - B4DZ84
swissprot - A0A0D9SFF8
swissprot - A0A0C4DH75
swissprot - A0A0A0MRU0
swissprot - A0A087X0C7
swissprot - A0A087WVY2
swissprot - Q14168
swissprot - E5RK50
Ensembl - ENSG00000108852
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mpp2aENSDARG00000053453Danio rerio
 mpp2bENSDARG00000010957Danio rerio
 MPP2ENSGALG00000035580Gallus gallus
 Mpp2ENSMUSG00000017314Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MPP6 / Q9NZW5 / membrane palmitoylated protein 6ENSG0000010592663
CASK / O14936 / calcium/calmodulin dependent serine protein kinaseENSG0000014704440
MPP7 / Q5T2T1 / membrane palmitoylated protein 7ENSG0000015005434
MPP3 / Q13368 / membrane palmitoylated protein 3ENSG0000016164732
MPP1 / Q00013 / membrane palmitoylated protein 1ENSG0000013083031
MPP5 / Q8N3R9 / membrane palmitoylated protein 5ENSG0000007241530
MPP4 / Q96JB8 / membrane palmitoylated protein 4ENSG0000008212629
DLG2 / Q15700 / discs large MAGUK scaffold protein 2ENSG0000015067225
DLG3 / Q92796 / discs large MAGUK scaffold protein 3ENSG0000008245825
DLG1 / Q12959 / discs large MAGUK scaffold protein 1ENSG0000007571125
DLG4 / P78352 / discs large MAGUK scaffold protein 4ENSG0000013253524
TJP1 / Q07157 / tight junction protein 1ENSG0000010406718
TJP2 / Q9UDY2 / tight junction protein 2ENSG0000011913918
AL358113.1ENSG0000028513018
TJP3 / O95049 / tight junction protein 3ENSG0000010528917
DLG5 / Q8TDM6 / discs large MAGUK scaffold protein 5ENSG0000015120817
GUK1 / Q16774 / guanylate kinase 1ENSG0000014377410


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001478  PDZ domain
 IPR004172  L27 domain
 IPR008144  Guanylate kinase-like domain
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR014775  L27 domain, C-terminal
 IPR020590  Guanylate kinase, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035602  MPP2, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036034  PDZ superfamily
 IPR036892  L27 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0046037 GMP metabolic process IEA
 biological_processGO:0046710 GDP metabolic process IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0032590 dendrite membrane IEA
 cellular_componentGO:0032591 dendritic spine membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 molecular_functionGO:0004385 guanylate kinase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0044325 ion channel binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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