ENSG00000143774


Homo sapiens

Features
Gene ID: ENSG00000143774
  
Biological name :GUK1
  
Synonyms : guanylate kinase 1 / GUK1 / Q16774
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q42.13
Gene start: 228139962
Gene end: 228148984
  
Corresponding Affymetrix probe sets: 200075_s_at (Human Genome U133 Plus 2.0 Array)   213621_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355687
Ensembl peptide - ENSP00000355684
Ensembl peptide - ENSP00000355689
Ensembl peptide - ENSP00000407604
Ensembl peptide - ENSP00000403664
Ensembl peptide - ENSP00000401832
Ensembl peptide - ENSP00000375738
Ensembl peptide - ENSP00000355691
Ensembl peptide - ENSP00000317659
Ensembl peptide - ENSP00000355677
Ensembl peptide - ENSP00000355679
Ensembl peptide - ENSP00000355682
Ensembl peptide - ENSP00000355683
NCBI entrez gene - 2987     See in Manteia.
OMIM - 139270
RefSeq - XM_017001096
RefSeq - NM_001159391
RefSeq - NM_001242839
RefSeq - NM_001242840
RefSeq - XM_005273103
RefSeq - XM_005273104
RefSeq - XM_005273105
RefSeq - XM_005273106
RefSeq - XM_011544174
RefSeq - XM_017001091
RefSeq - XM_017001092
RefSeq - XM_017001093
RefSeq - XM_017001094
RefSeq - XM_017001095
RefSeq - NM_000858
RefSeq - NM_001159390
RefSeq Peptide - NP_001152863
RefSeq Peptide - NP_001229768
RefSeq Peptide - NP_001229769
RefSeq Peptide - NP_000849
RefSeq Peptide - NP_001152862
swissprot - B1ANG9
swissprot - B1ANH6
swissprot - Q16774
swissprot - Q6IBG8
swissprot - B1ANH5
swissprot - B1ANH3
swissprot - B1ANH2
swissprot - B1ANH0
Ensembl - ENSG00000143774
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 guk1aENSDARG00000030340Danio rerio
 guk1bENSDARG00000005776Danio rerio
 GUK1ENSGALG00000005336Gallus gallus
 Guk1ENSMUSG00000020444Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DLG4 / P78352 / discs large MAGUK scaffold protein 4ENSG0000013253529
MPP5 / Q8N3R9 / membrane palmitoylated protein 5ENSG0000007241529
MPP7 / Q5T2T1 / membrane palmitoylated protein 7ENSG0000015005429
MPP4 / Q96JB8 / membrane palmitoylated protein 4ENSG0000008212628
DLG2 / Q15700 / discs large MAGUK scaffold protein 2ENSG0000015067227
DLG1 / Q12959 / discs large MAGUK scaffold protein 1ENSG0000007571127
DLG3 / Q92796 / discs large MAGUK scaffold protein 3ENSG0000008245827
MPP6 / Q9NZW5 / membrane palmitoylated protein 6ENSG0000010592627
MPP2 / Q14168 / membrane palmitoylated protein 2ENSG0000010885226
MPP3 / Q13368 / membrane palmitoylated protein 3ENSG0000016164725
MPP1 / Q00013 / membrane palmitoylated protein 1ENSG0000013083023
CASK / O14936 / calcium/calmodulin dependent serine protein kinaseENSG0000014704421
DLG5 / Q8TDM6 / discs large MAGUK scaffold protein 5ENSG0000015120817
TJP1 / Q07157 / tight junction protein 1ENSG0000010406715
AL358113.1ENSG0000028513014
TJP3 / O95049 / tight junction protein 3ENSG0000010528914
TJP2 / Q9UDY2 / tight junction protein 2ENSG0000011913914


Protein motifs (from Interpro)
Interpro ID Name
 IPR008144  Guanylate kinase-like domain
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR017665  Guanylate kinase
 IPR020590  Guanylate kinase, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006163 purine nucleotide metabolic process IDA
 biological_processGO:0006185 dGDP biosynthetic process IEA
 biological_processGO:0015949 nucleobase-containing small molecule interconversion TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019673 GDP-mannose metabolic process IEA
 biological_processGO:0034436 glycoprotein transport IEA
 biological_processGO:0046034 ATP metabolic process IEA
 biological_processGO:0046037 GMP metabolic process IEA
 biological_processGO:0046054 dGMP metabolic process IEA
 biological_processGO:0046060 dATP metabolic process IEA
 biological_processGO:0046710 GDP metabolic process IEA
 biological_processGO:0046711 GDP biosynthetic process IEA
 biological_processGO:0046939 nucleotide phosphorylation IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004385 guanylate kinase activity EXP
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Abacavir metabolism
Interconversion of nucleotide di- and triphosphates


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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