ENSG00000150672


Homo sapiens

Features
Gene ID: ENSG00000150672
  
Biological name :DLG2
  
Synonyms : discs large MAGUK scaffold protein 2 / DLG2 / Q15700
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q14.1
Gene start: 83455012
Gene end: 85627922
  
Corresponding Affymetrix probe sets: 206253_at (Human Genome U133 Plus 2.0 Array)   228973_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385113
Ensembl peptide - ENSP00000381355
Ensembl peptide - ENSP00000391017
Ensembl peptide - ENSP00000436302
Ensembl peptide - ENSP00000436020
Ensembl peptide - ENSP00000435849
Ensembl peptide - ENSP00000435809
Ensembl peptide - ENSP00000434346
Ensembl peptide - ENSP00000434095
Ensembl peptide - ENSP00000433848
Ensembl peptide - ENSP00000432894
Ensembl peptide - ENSP00000409133
Ensembl peptide - ENSP00000403239
Ensembl peptide - ENSP00000402275
Ensembl peptide - ENSP00000393049
Ensembl peptide - ENSP00000280241
Ensembl peptide - ENSP00000365272
Ensembl peptide - ENSP00000381344
Ensembl peptide - ENSP00000381346
Ensembl peptide - ENSP00000381349
Ensembl peptide - ENSP00000381353
NCBI entrez gene - 1740     See in Manteia.
OMIM - 603583
RefSeq - XM_017017292
RefSeq - XM_017017269
RefSeq - XM_017017270
RefSeq - XM_017017271
RefSeq - XM_017017272
RefSeq - XM_017017273
RefSeq - XM_017017274
RefSeq - XM_017017275
RefSeq - XM_017017276
RefSeq - XM_017017277
RefSeq - XM_017017278
RefSeq - XM_017017279
RefSeq - XM_017017280
RefSeq - XM_017017281
RefSeq - XM_017017282
RefSeq - XM_017017283
RefSeq - XM_017017284
RefSeq - XM_017017285
RefSeq - XM_017017286
RefSeq - XM_017017287
RefSeq - XM_017017288
RefSeq - XM_017017289
RefSeq - XM_017017290
RefSeq - XM_017017291
RefSeq - NM_001142699
RefSeq - NM_001142700
RefSeq - NM_001142702
RefSeq - NM_001206769
RefSeq - NM_001300983
RefSeq - NM_001364
RefSeq - XM_005273810
RefSeq - XM_005273811
RefSeq - XM_011544778
RefSeq - XM_011544780
RefSeq - XM_011544782
RefSeq - XM_011544788
RefSeq - XM_017017254
RefSeq - XM_017017255
RefSeq - XM_017017256
RefSeq - XM_017017257
RefSeq - XM_017017258
RefSeq - XM_017017259
RefSeq - XM_017017260
RefSeq - XM_017017261
RefSeq - XM_017017262
RefSeq - XM_017017263
RefSeq - XM_017017264
RefSeq - XM_017017265
RefSeq - XM_017017266
RefSeq - XM_017017267
RefSeq - XM_017017268
RefSeq Peptide - NP_001193698
RefSeq Peptide - NP_001287912
RefSeq Peptide - NP_001355
RefSeq Peptide - NP_001136171
RefSeq Peptide - NP_001136172
RefSeq Peptide - NP_001136174
swissprot - E9PIJ9
swissprot - C9JFF9
swissprot - B7Z2T4
swissprot - B7Z264
swissprot - B5MCC5
swissprot - E9PRX3
swissprot - F8W750
swissprot - H7C325
swissprot - Q15700
swissprot - Q6ZSU2
swissprot - A8MUT9
swissprot - A8MVA8
swissprot - E9PRL2
swissprot - E9PQT9
swissprot - E9PPV7
swissprot - E9PN83
swissprot - E9PIW2
Ensembl - ENSG00000150672
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dlg2ENSDARG00000099323Danio rerio
 ENSGALG00000041225Gallus gallus
 Dlg2ENSMUSG00000052572Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DLG1 / Q12959 / discs large MAGUK scaffold protein 1ENSG0000007571166
DLG3 / Q92796 / discs large MAGUK scaffold protein 3ENSG0000008245857
DLG4 / P78352 / discs large MAGUK scaffold protein 4ENSG0000013253554
DLG5 / Q8TDM6 / discs large MAGUK scaffold protein 5ENSG0000015120820
TJP2 / Q9UDY2 / tight junction protein 2ENSG0000011913917
AL358113.1ENSG0000028513017
TJP3 / O95049 / tight junction protein 3ENSG0000010528917
MPP5 / Q8N3R9 / membrane palmitoylated protein 5ENSG0000007241517
TJP1 / Q07157 / tight junction protein 1ENSG0000010406717
MPP4 / Q96JB8 / membrane palmitoylated protein 4ENSG0000008212616
MPP7 / Q5T2T1 / membrane palmitoylated protein 7ENSG0000015005416
MPP3 / Q13368 / membrane palmitoylated protein 3ENSG0000016164716
MPP6 / Q9NZW5 / membrane palmitoylated protein 6ENSG0000010592615
MPP2 / Q14168 / membrane palmitoylated protein 2ENSG0000010885215
CASK / O14936 / calcium/calmodulin dependent serine protein kinaseENSG0000014704415
MPP1 / Q00013 / membrane palmitoylated protein 1ENSG0000013083012
GUK1 / Q16774 / guanylate kinase 1ENSG000001437747


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001478  PDZ domain
 IPR004172  L27 domain
 IPR008144  Guanylate kinase-like domain
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR015143  L27-1
 IPR016313  Disks large 1-like
 IPR019583  PDZ-associated domain of NMDA receptors
 IPR019590  Disks large homologue 1, N-terminal PEST domain
 IPR020590  Guanylate kinase, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035759  Disks Large homologue 2, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036034  PDZ superfamily
 IPR036892  L27 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0010923 negative regulation of phosphatase activity IDA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0043113 receptor clustering IBA
 biological_processGO:0046037 GMP metabolic process IEA
 biological_processGO:0046710 GDP metabolic process IEA
 biological_processGO:0097120 receptor localization to synapse IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISS
 cellular_componentGO:0008328 ionotropic glutamate receptor complex IBA
 cellular_componentGO:0014069 postsynaptic density IBA
 cellular_componentGO:0016020 membrane ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044224 juxtaparanode region of axon ISS
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IBA
 molecular_functionGO:0004385 guanylate kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019900 kinase binding IDA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IBA


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000033122 LRRC7 / Q96NW7 / leucine rich repeat containing 7  / complex
 ENSG00000116544 DLGAP3 / O95886 / DLG associated protein 3  / reaction / complex
 ENSG00000105464 GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2D  / reaction / complex
 ENSG00000113319 O14827 / RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2  / complex / reaction
 ENSG00000120251 GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2  / reaction
 ENSG00000058404 CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II beta  / complex / reaction
 ENSG00000155511 GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1  / reaction
 ENSG00000152578 GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4  / reaction
 ENSG00000077522 ACTN2 / P35609 / actinin alpha 2  / complex
 ENSG00000070808 CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alpha  / reaction / complex
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / complex / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / complex / reaction
 ENSG00000152822 GRM1 / Q13255 / glutamate metabotropic receptor 1  / reaction / complex
 ENSG00000145349 CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II delta  / reaction / complex
 ENSG00000051128 HOMER3 / Q9NSC5 / homer scaffolding protein 3  / complex / reaction
 ENSG00000136279 DBNL / Q9UJU6 / drebrin like  / complex / reaction
 ENSG00000103942 HOMER2 / Q9NSB8 / homer scaffolding protein 2  / complex / reaction
 ENSG00000148660 CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gamma  / reaction / complex
 ENSG00000152413 HOMER1 / Q86YM7 / homer scaffolding protein 1  / reaction / complex
 ENSG00000163110 PDLIM5 / Q96HC4 / PDZ and LIM domain 5  / complex / reaction
 ENSG00000168959 GRM5 / P41594 / glutamate metabotropic receptor 5  / reaction / complex
 ENSG00000277586 NEFL / P07196 / neurofilament light  / complex
 ENSG00000183454 GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2A  / complex / reaction
 ENSG00000161681 Q9Y566 / SHANK1 / SH3 and multiple ankyrin repeat domains 1  / complex / reaction
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / complex
 ENSG00000161509 GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2C  / complex / reaction
 ENSG00000170579 DLGAP1 / O14490 / DLG associated protein 1  / complex / reaction
 ENSG00000080845 DLGAP4 / Q9Y2H0 / DLG associated protein 4  / complex / reaction
 ENSG00000162105 Q9UPX8 / SHANK2 / SH3 and multiple ankyrin repeat domains 2  / reaction / complex
 ENSG00000183092 BEGAIN / Q9BUH8 / brain enriched guanylate kinase associated  / complex / reaction
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / complex / reaction
 ENSG00000197555 O43166 / SIPA1L1 / signal induced proliferation associated 1 like 1  / reaction / complex
 ENSG00000058335 Q13972 / RASGRF1 / Ras protein specific guanine nucleotide releasing factor 1  / complex / reaction
 ENSG00000198010 DLGAP2 / Q9P1A6 / DLG associated protein 2  / reaction / complex
 ENSG00000125675 GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3  / reaction






 

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