ENSG00000168959


Homo sapiens

Features
Gene ID: ENSG00000168959
  
Biological name :GRM5
  
Synonyms : glutamate metabotropic receptor 5 / GRM5 / P41594
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q14.3
Gene start: 88504576
Gene end: 89065945
  
Corresponding Affymetrix probe sets: 1565389_s_at (Human Genome U133 Plus 2.0 Array)   207235_s_at (Human Genome U133 Plus 2.0 Array)   214217_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000305905
Ensembl peptide - ENSP00000376972
Ensembl peptide - ENSP00000403724
Ensembl peptide - ENSP00000405690
Ensembl peptide - ENSP00000306138
NCBI entrez gene - 2915     See in Manteia.
OMIM - 604102
RefSeq - XM_017017627
RefSeq - NM_000842
RefSeq - NM_001143831
RefSeq - XM_006718828
RefSeq - XM_011542792
RefSeq Peptide - NP_001137303
RefSeq Peptide - NP_000833
swissprot - H7C223
swissprot - P41594
swissprot - A8MT20
Ensembl - ENSG00000168959
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grm5aENSDARG00000004445Danio rerio
 grm5bENSDARG00000102067Danio rerio
 GRM5ENSGALG00000017238Gallus gallus
 Grm5ENSMUSG00000049583Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRM1 / Q13255 / glutamate metabotropic receptor 1ENSG0000015282260
GRM4 / Q14833 / glutamate metabotropic receptor 4ENSG0000012449331
GRM8 / O00222 / glutamate metabotropic receptor 8ENSG0000017960331
GRM3 / Q14832 / glutamate metabotropic receptor 3ENSG0000019882231
GRM2 / Q14416 / glutamate metabotropic receptor 2ENSG0000016408231
GRM7 / Q14831 / glutamate metabotropic receptor 7ENSG0000019627730
GRM6 / O15303 / glutamate metabotropic receptor 6ENSG0000011326228
GPRC6A / Q5T6X5 / G protein-coupled receptor class C group 6 member AENSG0000017361218
Q7RTX1 / TAS1R1 / taste 1 receptor member 1ENSG0000017366217
Q8TE23 / TAS1R2 / taste 1 receptor member 2ENSG0000017900217
Q7RTX0 / TAS1R3 / taste 1 receptor member 3ENSG0000016996215


Protein motifs (from Interpro)
Interpro ID Name
 IPR000162  GPCR, family 3, metabotropic glutamate receptor
 IPR000202  GPCR, family 3, metabotropic glutamate receptor 5
 IPR000337  GPCR, family 3
 IPR001828  Receptor, ligand binding region
 IPR011500  GPCR, family 3, nine cysteines domain
 IPR017978  GPCR family 3, C-terminal
 IPR017979  GPCR, family 3, conserved site
 IPR019588  Metabotropic glutamate receptor, Homer-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IGI
 biological_processGO:0006417 regulation of translation TAS
 biological_processGO:0006448 regulation of translational elongation IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IBA
 biological_processGO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway TAS
 biological_processGO:0007216 G-protein coupled glutamate receptor signaling pathway IMP
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007611 learning or memory ISS
 biological_processGO:0007612 learning IEA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source IGI
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IEA
 biological_processGO:0050808 synapse organization ISS
 biological_processGO:0050890 cognition IMP
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IBA
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity ISS
 biological_processGO:0090647 modulation of age-related behavioral decline ISS
 biological_processGO:0099566 regulation of postsynaptic cytosolic calcium ion concentration IEA
 biological_processGO:1902938 regulation of intracellular calcium activated chloride channel activity IGI
 biological_processGO:1904646 cellular response to amyloid-beta ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0014069 postsynaptic density IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042734 presynaptic membrane IBA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008066 glutamate receptor activity IDA
 molecular_functionGO:0030296 protein tyrosine kinase activator activity TAS
 molecular_functionGO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential IEA
 molecular_functionGO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IEA
 molecular_functionGO:1990782 protein tyrosine kinase binding ISS


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / reaction / complex
 ENSG00000051128 HOMER3 / Q9NSC5 / homer scaffolding protein 3  / complex / reaction
 ENSG00000116544 DLGAP3 / O95886 / DLG associated protein 3  / complex / reaction
 ENSG00000152413 HOMER1 / Q86YM7 / homer scaffolding protein 1  / complex / reaction
 ENSG00000103942 HOMER2 / Q9NSB8 / homer scaffolding protein 2  / reaction / complex
 ENSG00000150672 DLG2 / Q15700 / discs large MAGUK scaffold protein 2  / complex / reaction
 ENSG00000161681 Q9Y566 / SHANK1 / SH3 and multiple ankyrin repeat domains 1  / complex / reaction
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / complex / reaction
 ENSG00000170579 DLGAP1 / O14490 / DLG associated protein 1  / complex / reaction
 ENSG00000080845 DLGAP4 / Q9Y2H0 / DLG associated protein 4  / complex / reaction
 ENSG00000162105 Q9UPX8 / SHANK2 / SH3 and multiple ankyrin repeat domains 2  / reaction / complex
 ENSG00000198010 DLGAP2 / Q9P1A6 / DLG associated protein 2  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr