ENSMUSG00000049583


Mus musculus

Features
Gene ID: ENSMUSG00000049583
  
Biological name :Grm5
  
Synonyms : glutamate receptor, metabotropic 5 / Grm5 / Q3UVX5
  
Possible biological names infered from orthology : glutamate metabotropic receptor 5 / P41594
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: D3
Gene start: 87584168
Gene end: 88134907
  
Corresponding Affymetrix probe sets: 10554778 (MoGene1.0st)   1443410_at (Mouse Genome 430 2.0 Array)   1455272_at (Mouse Genome 430 2.0 Array)   1456119_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118393
Ensembl peptide - ENSMUSP00000102884
Ensembl peptide - ENSMUSP00000114927
NCBI entrez gene - 108071     See in Manteia.
MGI - MGI:1351342
RefSeq - XM_011241643
RefSeq - NM_001081414
RefSeq - NM_001143834
RefSeq - XM_006507184
RefSeq Peptide - NP_001074883
RefSeq Peptide - NP_001137306
swissprot - E9QMC2
swissprot - Q3UVX5
swissprot - B2BH30
Ensembl - ENSMUSG00000049583
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grm5aENSDARG00000004445Danio rerio
 grm5bENSDARG00000102067Danio rerio
 GRM5ENSGALG00000017238Gallus gallus
 GRM5ENSG00000168959Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grm1 / P97772 / Metabotropic glutamate receptor 1 / Q13255* / glutamate metabotropic receptor 1*ENSMUSG0000001982861
Grm2 / Q14BI2 / Metabotropic glutamate receptor 2 / Q14416* / glutamate metabotropic receptor 2*ENSMUSG0000002319232
Grm3 / Q9QYS2 / Metabotropic glutamate receptor 3 / Q14832* / glutamate metabotropic receptor 3*ENSMUSG0000000397431
Grm4 / glutamate receptor, metabotropic 4 / Q14833* / glutamate metabotropic receptor 4*ENSMUSG0000006323931
Grm8 / P47743 / glutamate receptor, metabotropic 8 / O00222* / glutamate metabotropic receptor 8*ENSMUSG0000002421131
Grm7 / Q68ED2 / Metabotropic glutamate receptor 7 / Q14831* / glutamate metabotropic receptor 7*ENSMUSG0000005675530
Grm6 / Q5NCH9 / Metabotropic glutamate receptor 6 / O15303* / glutamate metabotropic receptor 6*ENSMUSG0000000061729
Gprc6a / Q8K4Z6 / G protein-coupled receptor, family C, group 6, member A / Q5T6X5* / G protein-coupled receptor class C group 6 member A*ENSMUSG0000001990517
Q925D8 / Tas1r3 / Taste receptor type 1 member 3 / Q7RTX0* / taste 1 receptor member 3*ENSMUSG0000002907216
Tas1r1 / taste receptor, type 1, member 1 / Q7RTX1* / taste 1 receptor member 1*ENSMUSG0000002895016
Q925I4 / Tas1r2 / taste receptor, type 1, member 2 / Q8TE23* / taste 1 receptor member 2*ENSMUSG0000002873815


Protein motifs (from Interpro)
Interpro ID Name
 IPR000162  GPCR, family 3, metabotropic glutamate receptor
 IPR000202  GPCR, family 3, metabotropic glutamate receptor 5
 IPR000337  GPCR, family 3
 IPR001828  Receptor, ligand binding region
 IPR011500  GPCR, family 3, nine cysteines domain
 IPR017978  GPCR family 3, C-terminal
 IPR017979  GPCR, family 3, conserved site
 IPR019588  Metabotropic glutamate receptor, Homer-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006448 regulation of translational elongation ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IBA
 biological_processGO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway IEA
 biological_processGO:0007216 G-protein coupled glutamate receptor signaling pathway ISS
 biological_processGO:0007611 learning or memory IGI
 biological_processGO:0007612 learning IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source IGI
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IMP
 biological_processGO:0050808 synapse organization IGI
 biological_processGO:0050890 cognition IEA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IBA
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IGI
 biological_processGO:0090647 modulation of age-related behavioral decline IGI
 biological_processGO:0099566 regulation of postsynaptic cytosolic calcium ion concentration IEA
 biological_processGO:1902938 regulation of intracellular calcium activated chloride channel activity ISO
 biological_processGO:1904646 cellular response to amyloid-beta ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042734 presynaptic membrane IBA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001639 PLC activating G-protein coupled glutamate receptor activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008066 glutamate receptor activity ISO
 molecular_functionGO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential IMP
 molecular_functionGO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IMP


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Grm5tm1.2Jixu/Grm5tm1.2Jixu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Grm5tm1.2Jixu/Grm5tm1.2Jixu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Grm5tm1Fcq/Grm5tm1Fcq
Genetic Background: Not Specified

 MP:0001496 audiogenic seizures "a reflex seizure triggered by loud noises" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fmr1tm1Cgr/Y,Grm5tm1Rod/Grm5+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002556 cocaine consumption 
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Allelic Composition: Sipa1tm1Nm/Sipa1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gabbr1tm2Bet/Gabbr1tm2Bet,Hdctm1.1(icre)Wwis/Hdc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
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Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: involves: 129 * C57BL/6

 MP:0003477 abnormal nerve fiber response "anomaly in the electrophysiological recordings from a single or several nerve fiber(s)" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Pax6Sey/Pax6Sey-H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/10

 MP:0003546 decreased alcohol consumption "less than normal consumption of alcohol" [RGD:Rat Genome Database submission]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)71Vbo/?,Themis5AT161/Themis5AT161
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0004851 increased testis weight "greater average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fmr1tm1Cgr/Y,Grm5tm1Rod/Grm5+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0006299 abnormal latent inhibition of conditioning behavior "anomaly in the impairment in a conditioned response seen after repeated unpaired presentations of the conditioned stimulus prior to pairing it with the unconditioned stimulus" [Additction research lab:http://dionysus.psych.wisc.edu/ARL/research-current.html, brs:Beverly Richards-Smith_IMSR Curator, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grm5tm1.2Jixu/Grm5tm1.2Jixu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0009758 impaired behavioral response to cocaine "decreased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grm5tm1Fcq/Grm5tm1Fcq
Genetic Background: Not Specified

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0020340 abnormal inhibitory learning "anomaly in the process by which a subject learns to suppress a prior learned response" [http://cognitivedefusion.tumblr.com/post/90402024947/what-is-inhibitory-learning, ORCID: orcid.org/0000-0003-4606-0597, PMID:19321764]
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Allelic Composition: Grm5tm1.2Jixu/Grm5tm1.2Jixu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003573 Homer3 / Q99JP6 / Homer protein homolog 3 / Q9NSC5* / homer scaffolding protein 3*  / reaction / complex
 ENSMUSG00000025813 Homer2 / Q9QWW1 / Homer protein homolog 2 / Q9NSB8* / homer scaffolding protein 2*  / complex / reaction
 ENSMUSG00000007617 Homer1 / Q9Z2Y3 / Homer protein homolog 1 / Q86YM7* / homer scaffolding protein 1*  / reaction / complex






 

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