ENSMUSG00000019905


Mus musculus

Features
Gene ID: ENSMUSG00000019905
  
Biological name :Gprc6a
  
Synonyms : Gprc6a / G protein-coupled receptor, family C, group 6, member A / Q8K4Z6
  
Possible biological names infered from orthology : G protein-coupled receptor class C group 6 member A / Q5T6X5
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B3
Gene start: 51614823
Gene end: 51631461
  
Corresponding Affymetrix probe sets: 10369028 (MoGene1.0st)   1428053_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020062
Ensembl peptide - ENSMUSP00000151341
Ensembl peptide - ENSMUSP00000152031
NCBI entrez gene - 210198     See in Manteia.
MGI - MGI:2429498
RefSeq - NM_153071
RefSeq Peptide - NP_694711
swissprot - Q8K4Z6
Ensembl - ENSMUSG00000019905
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gprc6aENSDARG00000005371Danio rerio
 GPRC6AENSGALG00000014925Gallus gallus
 GPRC6AENSG00000173612Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q925I4 / Tas1r2 / taste receptor, type 1, member 2 / Q8TE23* / taste 1 receptor member 2*ENSMUSG0000002873826
Q925D8 / Tas1r3 / Taste receptor type 1 member 3 / Q7RTX0* / taste 1 receptor member 3*ENSMUSG0000002907226
Tas1r1 / taste receptor, type 1, member 1 / Q7RTX1* / taste 1 receptor member 1*ENSMUSG0000002895026
Grm3 / Q9QYS2 / Metabotropic glutamate receptor 3 / Q14832* / glutamate metabotropic receptor 3*ENSMUSG0000000397424
Grm2 / Q14BI2 / Metabotropic glutamate receptor 2 / Q14416* / glutamate metabotropic receptor 2*ENSMUSG0000002319224
Grm6 / Q5NCH9 / Metabotropic glutamate receptor 6 / O15303* / glutamate metabotropic receptor 6*ENSMUSG0000000061723
Grm4 / glutamate receptor, metabotropic 4 / Q14833* / glutamate metabotropic receptor 4*ENSMUSG0000006323923
Grm1 / P97772 / Metabotropic glutamate receptor 1 / Q13255* / glutamate metabotropic receptor 1*ENSMUSG0000001982823
Grm7 / Q68ED2 / Metabotropic glutamate receptor 7 / Q14831* / glutamate metabotropic receptor 7*ENSMUSG0000005675522
Grm5 / Q3UVX5 / glutamate receptor, metabotropic 5 / P41594* / glutamate metabotropic receptor 5*ENSMUSG0000004958322
Grm8 / P47743 / glutamate receptor, metabotropic 8 / O00222* / glutamate metabotropic receptor 8*ENSMUSG0000002421122


Protein motifs (from Interpro)
Interpro ID Name
 IPR000337  GPCR, family 3
 IPR001828  Receptor, ligand binding region
 IPR011500  GPCR, family 3, nine cysteines domain
 IPR017978  GPCR family 3, C-terminal
 IPR017979  GPCR, family 3, conserved site
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0019722 calcium-mediated signaling IDA
 biological_processGO:0043200 response to amino acid IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IDA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gprc6atm1.1Kry/Gprc6atm1.1Kry,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap2+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001565 abnormal circulating phosphate level "anomalous blood concentrations of this salt or ester of phosphoric acid; often associated with anomalous bone mineralization " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Gprc6atm1.1Kry/Gprc6atm1.1Kry,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap2+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002901 hyperphosphaturia "an increase of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gprc6atm1.1Kry/Gprc6atm1.1Kry,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap2+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004910 decreased seminal gland weight "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gprc6atm1.1Kry/Gprc6atm1.1Kry,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap2+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004929 decreased epididymis weight "reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gprc6atm1.1Kry/Gprc6atm1.1Kry,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap2+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005182 increased circulating estradiol level "greater than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005291 abnormal glucose tolerance "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gprc6atm1.1Kry/Gprc6atm1.1Kry,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

 MP:0009199 abnormal external male genitalia morphology "any structural anomaly of the external masculine genital organs, including the penis and scrotum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009205 abnormal internal male genitalia morphology "any structural anomaly of the internal masculine genital organs, including the testes, epididymides, deferent ducts, seminal vesicles, prostate, ejaculatory ducts, and bulbourethral glands" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011556 increased urine beta2-microglobulin level "greater than the normal amount of beta2-microglobulin in the urine; may indicate renal tubule disease, drug-induced renal toxicity, heavy metal-induced renal disease, lymphomas, leukemia, or myeloma" [MGI:anna]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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