ENSMUSG00000023192


Mus musculus

Features
Gene ID: ENSMUSG00000023192
  
Biological name :Grm2
  
Synonyms : Grm2 / Metabotropic glutamate receptor 2 / Q14BI2
  
Possible biological names infered from orthology : glutamate metabotropic receptor 2 / Q14416
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F1
Gene start: 106643095
Gene end: 106656082
  
Corresponding Affymetrix probe sets: 10596521 (MoGene1.0st)   1435607_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023959
Ensembl peptide - ENSMUSP00000144631
Ensembl peptide - ENSMUSP00000144076
NCBI entrez gene - 108068     See in Manteia.
MGI - MGI:1351339
RefSeq - NM_001160353
RefSeq Peptide - NP_001153825
swissprot - A0A0J9YVF0
swissprot - A0A0J9YU95
swissprot - Q14BI2
Ensembl - ENSMUSG00000023192
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grm2aENSDARG00000004150Danio rerio
 grm2bENSDARG00000007195Danio rerio
 GRM2ENSGALG00000003839Gallus gallus
 GRM2ENSG00000164082Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grm3 / Q9QYS2 / Metabotropic glutamate receptor 3 / Q14832* / glutamate metabotropic receptor 3*ENSMUSG0000000397468
Grm8 / P47743 / glutamate receptor, metabotropic 8 / O00222* / glutamate metabotropic receptor 8*ENSMUSG0000002421146
Grm4 / glutamate receptor, metabotropic 4 / Q14833* / glutamate metabotropic receptor 4*ENSMUSG0000006323946
Grm7 / Q68ED2 / Metabotropic glutamate receptor 7 / Q14831* / glutamate metabotropic receptor 7*ENSMUSG0000005675545
Grm6 / Q5NCH9 / Metabotropic glutamate receptor 6 / O15303* / glutamate metabotropic receptor 6*ENSMUSG0000000061745
Grm1 / P97772 / Metabotropic glutamate receptor 1 / Q13255* / glutamate metabotropic receptor 1*ENSMUSG0000001982844
Grm5 / Q3UVX5 / glutamate receptor, metabotropic 5 / P41594* / glutamate metabotropic receptor 5*ENSMUSG0000004958344
Gprc6a / Q8K4Z6 / G protein-coupled receptor, family C, group 6, member A / Q5T6X5* / G protein-coupled receptor class C group 6 member A*ENSMUSG0000001990526
Q925D8 / Tas1r3 / Taste receptor type 1 member 3 / Q7RTX0* / taste 1 receptor member 3*ENSMUSG0000002907223
Q925I4 / Tas1r2 / taste receptor, type 1, member 2 / Q8TE23* / taste 1 receptor member 2*ENSMUSG0000002873822
Tas1r1 / taste receptor, type 1, member 1 / Q7RTX1* / taste 1 receptor member 1*ENSMUSG0000002895022


Protein motifs (from Interpro)
Interpro ID Name
 IPR000162  GPCR, family 3, metabotropic glutamate receptor
 IPR000337  GPCR, family 3
 IPR001458  GPCR, family 3, metabotropic glutamate receptor 2
 IPR001828  Receptor, ligand binding region
 IPR011500  GPCR, family 3, nine cysteines domain
 IPR017978  GPCR family 3, C-terminal
 IPR017979  GPCR, family 3, conserved site
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IEA
 biological_processGO:0014047 glutamate secretion IEA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IBA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0001641 group II metabotropic glutamate receptor activity IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005246 calcium channel regulator activity IDA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001362 abnormal anxiety-related response "altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Pou4f3tm1Xia/Pou4f3tm1Xia
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001988 cocaine preference 
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0011987 abnormal GABAergic neuron physiology "any functional anomaly of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter" [PMID:8787741]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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