ENSMUSG00000063239


Mus musculus

Features
Gene ID: ENSMUSG00000063239
  
Biological name :Grm4
  
Synonyms : glutamate receptor, metabotropic 4 / Grm4
  
Possible biological names infered from orthology : glutamate metabotropic receptor 4 / Q14833
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 27422387
Gene end: 27513341
  
Corresponding Affymetrix probe sets: 10449343 (MoGene1.0st)   1457299_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112578
Ensembl peptide - ENSMUSP00000113819
NCBI entrez gene - 268934     See in Manteia.
MGI - MGI:1351341
RefSeq - XM_017317482
RefSeq - XM_006524319
RefSeq - XM_006524320
RefSeq - XM_006524321
RefSeq - XM_011246475
RefSeq - NM_001013385
RefSeq - NM_001291045
RefSeq - XM_006524317
RefSeq Peptide - NP_001277974
RefSeq Peptide - NP_001013403
swissprot - G3XA00
swissprot - A0A140T8R6
Ensembl - ENSMUSG00000063239
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grm4ENSDARG00000040156Danio rerio
 GRM4ENSGALG00000002840Gallus gallus
 GRM4ENSG00000124493Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grm8 / P47743 / glutamate receptor, metabotropic 8 / O00222* / glutamate metabotropic receptor 8*ENSMUSG0000002421173
Grm7 / Q68ED2 / Metabotropic glutamate receptor 7 / Q14831* / glutamate metabotropic receptor 7*ENSMUSG0000005675568
Grm6 / Q5NCH9 / Metabotropic glutamate receptor 6 / O15303* / glutamate metabotropic receptor 6*ENSMUSG0000000061765
Grm2 / Q14BI2 / Metabotropic glutamate receptor 2 / Q14416* / glutamate metabotropic receptor 2*ENSMUSG0000002319244
Grm3 / Q9QYS2 / Metabotropic glutamate receptor 3 / Q14832* / glutamate metabotropic receptor 3*ENSMUSG0000000397443
Grm5 / Q3UVX5 / glutamate receptor, metabotropic 5 / P41594* / glutamate metabotropic receptor 5*ENSMUSG0000004958341
Grm1 / P97772 / Metabotropic glutamate receptor 1 / Q13255* / glutamate metabotropic receptor 1*ENSMUSG0000001982840
Gprc6a / Q8K4Z6 / G protein-coupled receptor, family C, group 6, member A / Q5T6X5* / G protein-coupled receptor class C group 6 member A*ENSMUSG0000001990523
Q925I4 / Tas1r2 / taste receptor, type 1, member 2 / Q8TE23* / taste 1 receptor member 2*ENSMUSG0000002873822
Tas1r1 / taste receptor, type 1, member 1 / Q7RTX1* / taste 1 receptor member 1*ENSMUSG0000002895021
Q925D8 / Tas1r3 / Taste receptor type 1 member 3 / Q7RTX0* / taste 1 receptor member 3*ENSMUSG0000002907220


Protein motifs (from Interpro)
Interpro ID Name
 IPR000162  GPCR, family 3, metabotropic glutamate receptor
 IPR000337  GPCR, family 3
 IPR001786  GPCR, family 3, metabotropic glutamate receptor 4
 IPR001828  Receptor, ligand binding region
 IPR011500  GPCR, family 3, nine cysteines domain
 IPR017978  GPCR family 3, C-terminal
 IPR017979  GPCR, family 3, conserved site
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008066 glutamate receptor activity IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0002920 reduced paired-pulse facilitation "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0002922 decreased post-tetanic potential "reduction in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0009141 increased prepulse inhibition "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr