ENSMUSG00000024211


Mus musculus

Features
Gene ID: ENSMUSG00000024211
  
Biological name :Grm8
  
Synonyms : glutamate receptor, metabotropic 8 / Grm8 / P47743
  
Possible biological names infered from orthology : glutamate metabotropic receptor 8 / O00222
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A3.2
Gene start: 27275119
Gene end: 28135178
  
Corresponding Affymetrix probe sets: 10543494 (MoGene1.0st)   10543510 (MoGene1.0st)   1421530_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120394
Ensembl peptide - ENSMUSP00000110978
Ensembl peptide - ENSMUSP00000110979
Ensembl peptide - ENSMUSP00000118098
Ensembl peptide - ENSMUSP00000087998
NCBI entrez gene - 14823     See in Manteia.
MGI - MGI:1351345
RefSeq - XM_017321398
RefSeq - NM_001311072
RefSeq - NM_008174
RefSeq - XM_006504987
RefSeq - XM_006504989
RefSeq - XM_006504990
RefSeq - XM_006504991
RefSeq - XM_017321397
RefSeq Peptide - NP_032200
RefSeq Peptide - NP_001298001
swissprot - Q05BD6
swissprot - D3YZL1
swissprot - P47743
swissprot - B7ZMR4
swissprot - D3YZK8
Ensembl - ENSMUSG00000024211
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grm8aENSDARG00000077654Danio rerio
 grm8bENSDARG00000076508Danio rerio
 GRM8ENSGALG00000039403Gallus gallus
 GRM8ENSG00000179603Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grm4 / glutamate receptor, metabotropic 4 / Q14833* / glutamate metabotropic receptor 4*ENSMUSG0000006323974
Grm7 / Q68ED2 / Metabotropic glutamate receptor 7 / Q14831* / glutamate metabotropic receptor 7*ENSMUSG0000005675573
Grm6 / Q5NCH9 / Metabotropic glutamate receptor 6 / O15303* / glutamate metabotropic receptor 6*ENSMUSG0000000061766
Grm3 / Q9QYS2 / Metabotropic glutamate receptor 3 / Q14832* / glutamate metabotropic receptor 3*ENSMUSG0000000397444
Grm2 / Q14BI2 / Metabotropic glutamate receptor 2 / Q14416* / glutamate metabotropic receptor 2*ENSMUSG0000002319244
Grm5 / Q3UVX5 / glutamate receptor, metabotropic 5 / P41594* / glutamate metabotropic receptor 5*ENSMUSG0000004958342
Grm1 / P97772 / Metabotropic glutamate receptor 1 / Q13255* / glutamate metabotropic receptor 1*ENSMUSG0000001982841
Gprc6a / Q8K4Z6 / G protein-coupled receptor, family C, group 6, member A / Q5T6X5* / G protein-coupled receptor class C group 6 member A*ENSMUSG0000001990523
Q925I4 / Tas1r2 / taste receptor, type 1, member 2 / Q8TE23* / taste 1 receptor member 2*ENSMUSG0000002873822
Q925D8 / Tas1r3 / Taste receptor type 1 member 3 / Q7RTX0* / taste 1 receptor member 3*ENSMUSG0000002907220
Tas1r1 / taste receptor, type 1, member 1 / Q7RTX1* / taste 1 receptor member 1*ENSMUSG0000002895020


Protein motifs (from Interpro)
Interpro ID Name
 IPR000144  GPCR, family 3, metabotropic glutamate receptor 8
 IPR000162  GPCR, family 3, metabotropic glutamate receptor
 IPR000337  GPCR, family 3
 IPR001828  Receptor, ligand binding region
 IPR011500  GPCR, family 3, nine cysteines domain
 IPR017978  GPCR family 3, C-terminal
 IPR017979  GPCR, family 3, conserved site
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway ISO
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0035249 synaptic transmission, glutamatergic TAS
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042734 presynaptic membrane IBA
 molecular_functionGO:0001642 group III metabotropic glutamate receptor activity IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008066 glutamate receptor activity ISO


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Acadvltm1Vje/Acadvl+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Acadvltm1Vje/Acadvl+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Acadvltm1Vje/Acadvl+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Acadvltm1Vje/Acadvl+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acadvltm1Vje/Acadvl+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Acadvltm1Vje/Acadvl+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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