MP:0000160 | kyphosis | "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
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MP:0000233 | abnormal blood flow velocity | "anomalous rate of flow of the blood through vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
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MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
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MP:0000280 | thin ventricular wall | "decreased depth of the cardiac wall of the heart ventricles" [J:45302] |
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Allelic Composition: Aiapy/Aiapy Genetic Background: involves: C3H/HeJ * C57BL/6J
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MP:0000281 | abnormal ventricular septum morphology | "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Aiapy/Aiapy Genetic Background: involves: C3H/HeJ * C57BL/6J
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MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Glra1tm1Rah/Glra1tm1Rah Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0000747 | muscle weakness | "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
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MP:0000753 | paralysis | "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * C57BL/6 * FVB
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MP:0000759 | abnormal skeletal muscle morphology | "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2*A111G)591Ahmb/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0000937 | abnormal motor neuron morphology | "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0000938 | motor neuron degeneration | "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Glra1tm1Rah/Glra1tm1Rah Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * C57BL/6 * FVB
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MP:0000939 | reduced motor neuron number | "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
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MP:0000947 | convulsive seizures | "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Grm1m1Btlr/Grm1m1Btlr Genetic Background: C57BL/6J-Grm1m1Btlr
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MP:0000955 | abnormal spinal cord morphology | "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * C57BL/6 * FVB
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MP:0000968 | abnormal sensory neuron innervation | "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622] |
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
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MP:0001007 | abnormal sympathetic system morphology | "malformation of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
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MP:0001052 | abnormal muscle innervation | "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd/J
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * C57BL/6 * FVB
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MP:0001053 | abnormal neuromuscular synapse | "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd/J
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0001220 | epidermal necrosis | "pathological cell death in the epidermal layer of the skin, usually due to irreversible damage" [J:65146] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: B6.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/0 Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
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MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
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Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb
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MP:0001436 | abnormal suckling behavior | "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461] |
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Allelic Composition: Glra1tm1Rah/Glra1tm1Rah Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0001443 | poor grooming | "below average standard of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [MGI:CLS, J:30404] |
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Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0001469 | abnormal contextual conditioning | "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ
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MP:0001513 | limb grasping | "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0001516 | abnormal motor coordination/ balance | "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Smn1tm1Cdid/Smn1tm1.1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * C57BL/6 * FVB
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MP:0001523 | impaired righting response | "reduced ability or greater amount of time needed to recover from supine position" [J:25565] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0001524 | impaired limb coordination | "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb
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MP:0001525 | impaired balance | "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb
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MP:0001636 | irregular heartbeat | "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038] |
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
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MP:0001921 | reduced fertility | "diminished ability to produce live offspring" [J:65030] |
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Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Glra1tm1Rah/Glra1tm1Rah Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0001956 | hypopnea | "breathing that is shallower and/or slower than normal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64289] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0002064 | seizures | "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ
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MP:0002066 | abnormal motor capabilities/coordination/movement | "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Slc6a3tm1Hhg/Slc6a3tm1Hhg Genetic Background: B6.129X1-Slc6a3tm1Hhg
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MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/0 Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(Prnp-SMN)92Ahmb/Tg(Prnp-SMN)92Ahmb,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(Prnp-SMN)92Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(ACTA1-SMN)63Ahmb/Tg(ACTA1-SMN)63Ahmb,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0002108 | abnormal muscle morphology | "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sortm1(DTA)Jpmb,Tg(KRT14-cre/ERT)20Efu/? Genetic Background: involves: 129S/SvEv * CD-1
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * C57BL/6 * FVB
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MP:0002184 | abnormal innervation | "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
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MP:0002191 | abnormal artery morphology | "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Aiapy/Aiapy Genetic Background: involves: C3H/HeJ * C57BL/6J
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MP:0002206 | abnormal CNS synaptic transmission | "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
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MP:0002269 | muscular atrophy | "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
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MP:0002738 | hyperresponsive to tactile stimuli | "exaggerated reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Grm1m1Btlr/Grm1m1Btlr Genetic Background: C57BL/6J-Grm1m1Btlr
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MP:0002795 | dilated cardiomyopathy | "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
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MP:0002805 | abnormal conditioned taste aversion behavior | "a defect in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness " [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ
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MP:0002862 | altered righting response | "altered ability or changed amount of time needed to recover from supine position" [hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
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MP:0002906 | susceptibility to pharmacologically induced seizures | "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504] |
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer
Allelic Composition: Grm7tm1Betz/Grm7tm1Betz Genetic Background: B6.129P2-Grm7tm1Betz
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MP:0002910 | abnormal excitatory postsynaptic currents | "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Grm7tm1Betz/Grm7tm1Betz Genetic Background: B6.129P2-Grm7tm1Betz
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MP:0002913 | abnormal PNS synaptic transmission | "defect in the communication from a neuron to a target across a synapse in the peripheral nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
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MP:0003082 | abnormal gastrocnemius morphology | "anomaly in the the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2*A111G)591Ahmb/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0003233 | prolonged QT interval | "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
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MP:0003466 | decreased single cell response threshold | "reduction in the value at which a stimulus first elicits a recordable response" [Nmice:Neuromice Consortium Submission] |
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Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * C57BL/6 * FVB
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MP:0003635 | abnormal synaptic transmission | "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
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MP:0003674 | oxidative stress | "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0003896 | prolonged PQ interval | "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
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MP:0003928 | increased heart rate variability | "increased variation of beat-to-beat intervals of the heart, usually indicitive of a healthy heart" [RGD:Rat Genome Database submission] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
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MP:0004145 | abnormal muscle electrophysiology | "anomaly in the function of the musculature as it relates to electrical phenomena" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0004191 | neuronal intranuclear inclusions | "presence of aggregates of protein within the nuclei of neurons; frequently seen in Huntington s disease" [acv:Alicia Valenzuela_Genetic Resources Curator] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0004243 | abnormal motor nerve terminal sprouting | "aberrant response of a motor neuron to form new neuritic processes (sprouts) that emerge from the nodes of Ranvier or terminal arborizations in response to nerve injury (such as denervation), application of nerve toxin, or muscle inactivity (usually due to disease)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/Tg(SMN1*A2G)2023Ahmb,Grm7Tg(SMN2)89Ahmb/? Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0004835 | abnormal miniature endplate potential | "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
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MP:0005156 | bradykinesia | "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301] |
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Allelic Composition: Glra1tm1Rah/Glra1tm1Rah Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0005202 | lethargy | "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
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MP:0005333 | decreased heart rate | "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
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MP:0005402 | abnormal action potential | "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0005404 | abnormal axon morphology | "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0005608 | cardiac interstitial fibrosis | "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/0 Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
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MP:0006404 | abnormal lumbar dorsal root ganglion morphology | "any structural anomaly of the group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the lumbar vertebrae" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0008428 | abnormal spatial working memory | "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grm7tm1Betz/Grm7tm1Betz Genetic Background: B6.129P2-Grm7tm1Betz
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MP:0008571 | abnormal synaptic bouton morphology | "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750] |
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
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MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
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MP:0009399 | increased skeletal muscle fiber size | "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
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MP:0009400 | decreased skeletal muscle fiber size | "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(Prnp-SMN)92Ahmb/Tg(Prnp-SMN)92Ahmb,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(ACTA1-SMN)63Ahmb/Tg(ACTA1-SMN)63Ahmb,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/0 Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
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MP:0009402 | decreased skeletal muscle fiber diameter | "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd/J
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MP:0009406 | decreased skeletal muscle fiber number | "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
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MP:0009412 | skeletal muscle fiber degeneration | "pathological deterioration of skeletal muscle fiber tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
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MP:0009413 | skeletal muscle fiber atrophy | "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb
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MP:0009766 | increased sensitivity to xenobiotic induced morbidity/mortality | "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grm7tm1Betz/Grm7tm1Betz Genetic Background: B6.129P2-Grm7tm1Betz
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MP:0010053 | decreased grip strength | "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"] |
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0010392 | prolonged QRS complex duration | "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * C57BL/6 * FVB
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MP:0010506 | prolonged RR interval | "increase in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0010579 | increased heart left ventricle size | "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0010725 | thin interventricular septum | "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aiapy/Aiapy Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/0 Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
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MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Glra1tm1Rah/Glra1tm1Rah Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(ACTA1-SMN)69Ahmb/Tg(ACTA1-SMN)69Ahmb,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(ACTA1-SMN)63Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: B6.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: B6.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7+,Tg(SMN2*delta7)4299Ahmb/0 Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*)1951Ahmb/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
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MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Glra1tm1Rah/Glra1tm1Rah Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Aiapy/Aiapy Genetic Background: involves: C3H/HeJ * C57BL/6J
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MP:0011400 | complete lethality | "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: B6.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd
Allelic Composition: Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Smn1tm1Msd/Smn1tm1Msd Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * FVB/N
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MP:0013178 | tail necrosis | "morphological changes resulting from pathological death of tail tissue; usually due to irreversible damage" [MGI:anna] |
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(ACTA1-SMN)63Ahmb/Tg(ACTA1-SMN)63Ahmb,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb Genetic Background: involves: 129P2/OlaHsd * FVB/N
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