Manteia

ENSMUSG00000003974

Mus musculus

Features

Gene ID:	ENSMUSG00000003974

Biological name :	Grm3

Synonyms :	Grm3 / Metabotropic glutamate receptor 3 / Q9QYS2

Possible biological names infered from orthology :	glutamate metabotropic receptor 3 / Q14832

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	A1
Gene start:	9485541
Gene end:	9725170

Corresponding Affymetrix probe sets:	10528145 (MoGene1.0st) 1430136_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000004076 NCBI entrez gene - 108069 See in Manteia. MGI - MGI:1351340 RefSeq - NM_181850 RefSeq Peptide - NP_862898 swissprot - Q9QYS2 Ensembl - ENSMUSG00000003974

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
grm3	ENSDARG00000031712	Danio rerio
GRM3	ENSGALG00000006576	Gallus gallus
GRM3	ENSG00000198822	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Grm2 / Q14BI2 / Metabotropic glutamate receptor 2 / Q14416* / glutamate metabotropic receptor 2*	ENSMUSG00000023192	67
Grm8 / P47743 / glutamate receptor, metabotropic 8 / O00222* / glutamate metabotropic receptor 8*	ENSMUSG00000024211	45
Grm7 / Q68ED2 / Metabotropic glutamate receptor 7 / Q14831* / glutamate metabotropic receptor 7*	ENSMUSG00000056755	45
Grm4 / glutamate receptor, metabotropic 4 / Q14833* / glutamate metabotropic receptor 4*	ENSMUSG00000063239	44
Grm6 / Q5NCH9 / Metabotropic glutamate receptor 6 / O15303* / glutamate metabotropic receptor 6*	ENSMUSG00000000617	44
Grm1 / P97772 / Metabotropic glutamate receptor 1 / Q13255* / glutamate metabotropic receptor 1*	ENSMUSG00000019828	42
Grm5 / Q3UVX5 / glutamate receptor, metabotropic 5 / P41594* / glutamate metabotropic receptor 5*	ENSMUSG00000049583	42
Gprc6a / Q8K4Z6 / G protein-coupled receptor, family C, group 6, member A / Q5T6X5* / G protein-coupled receptor class C group 6 member A*	ENSMUSG00000019905	25
Tas1r1 / taste receptor, type 1, member 1 / Q7RTX1* / taste 1 receptor member 1*	ENSMUSG00000028950	22
Q925I4 / Tas1r2 / taste receptor, type 1, member 2 / Q8TE23* / taste 1 receptor member 2*	ENSMUSG00000028738	22
Q925D8 / Tas1r3 / Taste receptor type 1 member 3 / Q7RTX0* / taste 1 receptor member 3*	ENSMUSG00000029072	21

Protein motifs (from Interpro)

Interpro ID	Name
IPR000162	GPCR, family 3, metabotropic glutamate receptor
IPR000337	GPCR, family 3
IPR001234	GPCR, family 3, metabotropic glutamate receptor 3
IPR001828	Receptor, ligand binding region
IPR011500	GPCR, family 3, nine cysteines domain
IPR017978	GPCR family 3, C-terminal
IPR017979	GPCR, family 3, conserved site
IPR028082	Periplasmic binding protein-like I

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	IEA
biological_process	GO:0019233	sensory perception of pain	TAS
biological_process	GO:0035249	synaptic transmission, glutamatergic	TAS
biological_process	GO:0051930	regulation of sensory perception of pain	NAS
biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	IBA
biological_process	GO:0065009	regulation of molecular function	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IBA
cellular_component	GO:0014069	postsynaptic density	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030424	axon	IDA
cellular_component	GO:0042734	presynaptic membrane	IDA
cellular_component	GO:0043005	neuron projection	IDA
cellular_component	GO:0043197	dendritic spine	IDA
cellular_component	GO:0045211	postsynaptic membrane	IDA
cellular_component	GO:0048786	presynaptic active zone	NAS
molecular_function	GO:0001641	group II metabotropic glutamate receptor activity	IDA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0004930	G-protein coupled receptor activity	IEA
molecular_function	GO:0005246	calcium channel regulator activity	IDA

Pathways (from Reactome)

Pathway description

G alpha (i) signalling events

Class C/3 (Metabotropic glutamate/pheromone receptors)

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001362	abnormal anxiety-related response	"altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]	Show Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001556	increased circulating HDL cholesterol level	"higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grm1^tm1Dgen/Grm1^tm1Dgen Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004811	abnormal neuron physiology	"anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Tnf^tm2.1Gkl/Tnf^tm2.1Gkl,Tg(Fabp1-cre)1Jig/0 Genetic Background: involves: 129S/SvEv * FVB/N
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0008916	abnormal astrocyte physiology	"any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnf^tm2.1Gkl/Tnf^tm2.1Gkl,Tg(Fabp1-cre)1Jig/0 Genetic Background: involves: 129S/SvEv * FVB/N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr